Cladribine
3 Inquiries
4291-63-8
99%
2026-07-14
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Cladribine Cat No CEI-0318 Description Cladribine Alias 2-CdA, 2-chlorodeoxyadenosine, Leustatin CAS No 4291-63-8 Molecular Weight 285.69 Purity >99% Storage 2 years at -20 centigrade Synonyms 2-CdA, 2-chlorodeoxyadenosine, Leustatin Targets U266, RPMI8226, MM1.S cells Molecular Formula C10H12ClN5O3 Chemical Name (2R,3S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)-tetrahydrofuran-3-ol Solubility DMSO 57 mg/mL, Water In vitro Cladribine exerts remarkable activity in hairy cell leukemia (HCL), a chronic B-cell lymphoproliferative disorder, producing prolonged complete remissions. Cladribine induces accumulation of DNA strand breaks, and subsequently activates the tumor suppressor p53 in lymphocytes. Cladribine may modulate STAT3 activity in MM cells. Cladribine inhibits proliferation/survival of U266, RPMI8226 and MM1.S cells in a dose-dependent manner. While U266 is the least sensitive cell line, MM1.S is the most sensitive one to cladribine. Treatment with cladribine gradually increases the percentage of cells in the G1 phase of the cell cycle and reduces the percentage of cells in S phase. Cladribine appears to increase G2-M phase in U266 cells upon 24 hour-treatment. A dose-dependent increase in apoptosis induced by cladribine is seen in both RPMI8226 and MM1.S cells. Treatment with cladribine at 0.2 uM dramatically induces activation of caspase-3, -8, and -9 and PARP cleavage in a time-dependent manner in MM1.S. Cladribine significantly decreases the phospho-STAT3 (P-STAT3) levels in a dose-dependent manner, but has no effect on the total STAT3 protein levels. category Nucleoside Drugs(c1520) cas_num 4291-63-8 Basic Info-
Product Name:
Cladribine
Other Name:Adenosine,2-chloro-2′-deoxy-;2-Chloro-2′-deoxyadenosine;2-Chloro-2′-deoxy-β-adenosine;2-Chloro-6-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine;2-Chlorodeoxyadenosine;NSC 105014-F;Cladribine;RWJ 26251;Leustatin;2-CdA;Cladarabine;NSC 105014;CldAdo;Jk 6251;Biodribin;Leustat;(2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;Vero-Cladribine;Mavenclad;Litak;24757-90-2
CAS No.:4291-63-8
Molecular Formula:C10H12ClN5O3
InChIKeys:InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N
Molecular Weight:285.69
Exact Mass:285.69
EC Number:224-427-9
NSC Number:105014|105013
DSSTox ID:DTXSID50274315
HScode:29349990
Categories:
Characteristics-
PSA:
119
XLogP3:-0.1
Appearance:Solid
Density:2.03±0.1 g/cm3(Predicted)
Melting Point:208-210 °C @ Solvent: Ethanol
Boiling Point:387.1°C at 760 mmHg
Water Solubility:6.35e+00 g/L
Storage Conditions:2-8°C
Vapor Pressure:1.11X10-13 mm Hg at 25 deg C (est)
Toxicity:LD50 intraperitoneal in mouse: 150mg/kg
Specific rotation:D25 -18.8° (c = 1 in DMF)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
Skin irritation, Category 2
Eye irritation, Category 2
Acute toxicity - Category 3, Inhalation
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H311 Toxic in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H331 Toxic if inhaled
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
United Kingdom
Cladribine
10 G Dec 13, 2023 
Pakistan
Cladribine
1 KG May 19, 2025 
Brazil
Cladribina
1.00 KG Mar 28, 2025 Post an enquiry for this product
