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Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, sodium salt (1:1)

Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, sodium salt (1:1) structure

CAS No:
4563-84-2
Formula:
C10H11N3O3S.Na
Chemical Name:
Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, sodium salt (1:1)
Synonyms:
Benzenesulfonamide,4-amino-N-(5-methyl-3-isoxazolyl)-,sodium salt (1:1);Sulfanilamide,N1-(5-methyl-3-isoxazolyl)-,monosodium salt;Benzenesulfonamide,4-amino-N-(5-methyl-3-isoxazolyl)-,monosodium salt;Sodium,[N1-(5-methyl-3-isoxazolyl)sulfanilamido]-;Sodium sulfamethoxazole;Sulfisomezole sodium;Sulfamethoxazole sodium salt;Sulfamethoxazole sodium;879633-15-5
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Sulfamethoxazole sodium (Ro 4-2130 sodium) is a sulfonamide bacteriostatic antibiotic[1]. Sulfamethoxazole sodium is used to treat various urinary tract pathogens and in combination with Trimethoprim is considered the gold standard in the treatment of urinary tract infections (UTIs)[2].

Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, sodium salt (1:1) Basic Attributes

Molecular Weight：

275.259

Exact Mass：

275.034058

EC Number：

224-939-2

Characteristics

PSA：

111.80000

XLogP3：

3.01430

Computed Properties

Molecular Weight:276.27
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:276.04188168
Monoisotopic Mass:276.04188168
Topological Polar Surface Area:107
Heavy Atom Count:18
Formal Charge:1
Complexity:346
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Broad-spectrum antibiotics

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Co-sulfamethoxazole sodium eye drops
Ingredients	This product is a compound preparation. Each 10 ml contains 400 mg of sulfamethoxazole sodium, 200 mg of aminocaproic acid, 10 mg of dipotassium glycyrrhizinate, and 2 mg of chlorpheniramine maleate.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Compound
Manufacturer	Mentholatum (CHINA) Pharmaceuticals Limited

Sulfamethoxazole sodium
Indication	1. The combined use of urine alkalinizing drugs can increase the solubility of this product in alkaline urine and increase excretion. 2. It cannot be used in combination with para-aminobenzoic acid. Para-aminobenzoic acid can replace this product and be taken up by bacteria, and the two are antagonistic to each other. 3. When the following drugs are used together with this product, this product can replace the protein binding sites of these drugs, or inhibit their metabolism, resulting in prolonged drug action time or toxic reactions. Therefore, when these drugs are used at the same time as this product, or when used after the application of this product, their dosages need to be adjusted. Such drugs include oral anticoagulants, oral hypoglycemic drugs, methotrexate, phenytoin sodium and thiopental sodium. 4. The combined use with bone marrow suppressive drugs may enhance the adverse reactions of such drugs on the hematopoietic system. Such as leukopenia, thrombocytopenia, etc. If there is an indication to use the two drugs together, the possible consequences should be closely observed.
Specifications	API

Sulfamethoxazole sodium

Indication

1. The combined use of urine alkalinizing drugs can increase the solubility of this product in alkaline urine and increase excretion. 2. It cannot be used in combination with para-aminobenzoic acid. Para-aminobenzoic acid can replace this product and be taken up by bacteria, and the two are antagonistic to each other. 3. When the following drugs are used together with this product, this product can replace the protein binding sites of these drugs, or inhibit their metabolism, resulting in prolonged drug action time or toxic reactions. Therefore, when these drugs are used at the same time as this product, or when used after the application of this product, their dosages need to be adjusted. Such drugs include oral anticoagulants, oral hypoglycemic drugs, methotrexate, phenytoin sodium and thiopental sodium. 4. The combined use with bone marrow suppressive drugs may enhance the adverse reactions of such drugs on the hematopoietic system. Such as leukopenia, thrombocytopenia, etc. If there is an indication to use the two drugs together, the possible consequences should be closely observed.

Specifications

API

Registered Holders

Shouguang Fukang Pharmaceutical Co., Ltd.

China
Active

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Guide of Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, sodium salt (1:1)

Description
Basic Attributes
Characteristics
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-, sodium salt (1:1)

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