Tabersonine
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Tabersonine
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CAS No:
4429-63-4
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Formula:
C21H24N2O2
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Chemical Name:
Tabersonine
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Synonyms:
Aspidospermidine-3-carboxylic acid,2,3,6,7-tetradehydro-,methyl ester,(5α,12R,19α)-;Tabersonine;Aspidospermidine-3-carboxylic acid,2,3,6,7-tetradehydro-,methyl ester,(5α,12β,19α)-;1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid,3a-ethyl-3a,4,6,11,12,13a-hexahydro-,methyl ester;1H-Indolizino[8,1-cd]carbazole,aspidospermidine-3-carboxylic acid deriv.;(-)-Tabersonine;Tabersonin;6540-94-9;17794-57-9
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CAS No:
Description
Tabersonine is an indole alkaloid mainly isolated from Catharanthus roseus. Tabersonine disrupts Aβ(1-42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. Tabersonine has anti-inflammatory activities and acts as a potential therapeutic candidate for the treatment of ALI/ARDS[1].
Tabersonine is a monoterpenoid indole alkaloid with cytotoxic activity. It has a role as an antineoplastic agent and a metabolite. It is an alkaloid ester, a monoterpenoid indole alkaloid, a methyl ester and an organic heteropentacyclic compound. It is a conjugate base of a tabersoninium(1+).
Characteristics
41.57000
3.29710
Yellow to brownish powder, pungent odour
1.27 g/cm3
196 °C
488.7ºC at 760 mmHg
249.4ºC
1.651
Safety Information
NONH for all modes of transport
P301 + P312 + P330
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Tabersonine Use and Manufacturing
Alkaloid It has anti-tumor, blood pressure, blood sugar, and diuretic effects. Clinically, it is mainly used for the treatment and prevention of lymphosarcoma, leukemia, rhabdomyosarcoma, melanoma, seminoma, teratoma, and the treatment and prevention of hypertension and hyperglycemia. Glycyrrhizine has the effect of lowering blood pressure.
Computed Properties
Molecular Weight:336.4
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:336.183778013
Monoisotopic Mass:336.183778013
Topological Polar Surface Area:41.6
Heavy Atom Count:25
Complexity:669
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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