4-Ethylphenol

122.16

122.16

1363317

204-598-6

AGG7E6G0ZC

62012

DTXSID4021977

COLORLESS OR WHITE NEEDLES; TEND TO YELLOW ON EXPOSURE TO LIGHT

29071900

20.2

2.6

White to brownish Crystalline Mass or Crystals

1.011 g/cm³ @ Temp: 20 °C

46 °C

217.9 °C

213 °F

1.533

H2O: 4.9 g/L (25 ºC)

Store below +30°C.

0.13 mm Hg ( 20 °C)

4.2 (vs air)

POWERFUL WOODY-PHENOLIC, YET SOMEWHAT SWEET

SWEET SMOKEY

7.73e-07 atm-m3/mole

pK = 10.38 @ 20 °C|pK = 10.0 at 25 °C

Liquid Heat of Formation = 0.123319 cu m/kmol

III

8

UN 2430 8/PG 3

3

36/37/38-R36/37/38-34

26-36-S36-S26-45-36/37/39

SL4040000

Xi,C

Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents.

P280-P305 + P351 + P338-P310

H314

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Danger|H314 (91.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 1760 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, and P501|H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]|P280, P305+P351+P338, and P310

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

p-Ethylphenol was detected in industrial wastewater from the following industries: timber products (1 in 30 extracts), iron and steel manufacturing (1 in 7 extracts), petroleum refining (1 in 21 extracts), organics and plastics (1 in 49 extracts), rubber processing (1 in 18 extracts), mechanical products (1 in 26 extracts), and publicly-owned treatment works (1 in 44 extracts)(1). A coal-derived liquid taken from a non-catalytic direct liquefaction pilot plant contained p-ethylphenol at unreported concentrations(2). m- and p-ethylphenol (mixed) were detected in cigarette smoke at 1.2-2.8 mg/100 cigarettes(3). p-Ethylphenol was detected in a sample of finished water from the Blue Plains advanced waste treatment plant, Washington, DC in September 1974(4).

VITILIGO MAY BE DUE TO INHIBITION OF MELANOGENESIS BY PHENOLIC DEGRADATION PRODUCTS PRODUCED IN VIVO. P-ETHYLPHENOL WAS ACTIVE IN INHIBITING PIGMENT FORMATION FROM DOPA BY HUMAN & GUINEA PIG SKIN IN VITRO.

REPORTED FOUND IN YELLOW PASSION FRUIT.

p-Ethylphenol's production and use in the manufacture of phenolic resins, as an intermediate for pharmaceuticals and dyes, its use in the varnish industry, and as a starting material for the production of 4-vinylphenol and various antioxidants which are used in rubber and polymers(1) as well as its use as a food flavoring(2,3) may result in its release to the environment through various waste streams(SRC). p-Ethylphenol was measured in cigarette smoke(4).|p-Ethylphenol is extracted from brown coal low temperature tar(1).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 600(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(3), indicates that p-ethylphenol will have low mobility in soil(SRC). Based on limited data, biodegradation of this compound is likely. A system where water was passed through contaminated soil (initial p-ethylphenol concentration = 4000 ug/l) and then through an upflow aerated column was capable of 76% removal in 37 days(4). p-Ethylphenol's values for vapor pressure(5) and Henry's Law constant(5,6,SRC) indicate that volatilization from dry and moist soil surfaces is possible, but will not be a major fate process for this compound(SRC).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 600(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(3), indicates that p-ethylphenol may adsorb to suspended solids and sediment(SRC) in water. Based on limited soil study data, biodegradation of this compound is likely. 76% removal of p-ethylphenol in 37 days was seen in a soil column study(4). p-Ethylphenol should volatilize from water surfaces based on an estimated Henry's Law constant of 1.2X10-6 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure(5) and water solubility(6). Estimated half-lives for a model river and model lake are 33 and 245 days, respectively(3,SRC). An estimated BCF value of 54(3,SRC), from an experimental log Kow(2), suggests that p-ethylphenol may bioconcentrate in aquatic organisms(SRC) according to a recommended classification scheme(7).|ATMOSPHERIC FATE: According to a suggested classification scheme(1), a measured vapor pressure of 0.0372 mm Hg at 25 °C(2) indicates that p-ethylphenol will mainly exist in the vapor phase in the ambient atmosphere(SRC). Vapor-phase p-ethylphenol is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 9 hours(3,SRC).

The rate constant for the vapor-phase reaction of p-ethylphenol with photochemically produced hydroxyl radicals has been estimated as 4.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 9 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). p-Ethylphenol has a measured pKa of 10.0, indicating that under most environmental conditions this compound will exist mainly as the non-dissociated form(2).

An estimated BCF value of 54 was calculated for p-ethylphenol(SRC), using a measured log Kow of 2.58(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms may be an important fate process(SRC).

The Koc of p-ethylphenol is estimated as approximately 600(SRC), using a measured log Kow of 2.58(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that p-ethylphenol has low mobility in soil(SRC).

The Henry's Law constant for p-ethylphenol is estimated as 1.2X10-6 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 0.372 mm Hg at 25 °C(1), and water solubility, 4900 mg/L at 25 °C(2). This value indicates that p-ethylphenol will volatilize from water surfaces(3,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 33 days(3,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 245 days(3,SRC). p-Ethylphenol's values for vapor pressure(1) and Henry's Law constant(1,2,SRC) indicate that volatilization from dry and moist soil surfaces is not likely to be a major fate process for this compound(SRC).

GROUNDWATER: p-Ethylphenol was measured in groundwater from a site near a former asphalt production plant in Deventer, The Netherlands, at 4550 ug/L(1). p-Ethylphenol was detected in a leachate sample from the Southington landfill site in Connecticut at 0.1 mg/L(2).

6 of 46 human adipose tissue composite samples, collected in 1982, contained p-ethylphenol at unreported concentrations(1).

DATA OBTAINED FROM MEASUREMENTS OF DESORPTION OF PHENOLIC CMPD FROM HUMAN STRATUM CORNEUM WERE TREATED TO GIVE ESTIMATES OF STRATUM CORNEUM-H20 PARTITION COEFFICIENTS AND OF THE RELATIVE DIFFUSION COEFFICIENTS OF PHENOLIC CMPD IN STRATUM CORNEUM.

FROM A DOSE OF 100 MG/KG /ETHYLBENZENE/ ADMIN ORALLY TO RAT... URINARY METABOLITES P-ETHYLPHENOL...ABOUT 0.3%, & SMALLER QUANTITIES OF 1- & 2-PHENYLETHANOL...|YIELDS P-ETHYLANISOLE IN THE GUINEA PIG. /FROM TABLE/|4-Ethylphenol has known human metabolites that include (2S,3S,4S,5R)-6-(4-ethylphenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid.

THE MIN INHIBITORY CONCN (MIC) OF 4-ETHYLPHENOL AGAINST ESCHERICHIA COLI WAS 695 UG/ML. 4-ETHYLPHENOL CAUSES AN INCR IN THE PERMEABILITY OF THE CELL MEMBRANE TO MOLECULES SMALLER THAN TRICARBOXYLIC ACID CYCLE INTERMEDIATES, RESULTING IN AN APPARENT UNCOUPLING EFFECT.

4-ethylphenol

The purity of the commercial product is 98%.

All other chemical product and preparation manufacturing|Phenol, 4-ethyl-: ACTIVE|Phenol, 3(or 4)-ethyl-: INACTIVE|/SYNTHETIC FLAVORS/ BAKED GOODS 0.20 PPM; MARGARINE 0.20 PPM.|FLAVORS USEFUL IN: SMOKE FLAVORS.|FIFTEEN CMPD STRUCTURALLY RELATED TO P-CRESOL, AN OVIPOSITION ATTRACTANT OF AEDES TRISERIATUS WERE TESTED ON THIS SPECIES. ATTRACTANT ACTIVITY WAS SHOWN BY P-ETHYLPHENOL.|FEMA NUMBER 3156

GAS CHROMATOGRAPHY WITH WALL-COATED OPEN TUBULAR GLASS CAPILLARY COLUMNS HAS BECOME WIDELY USED FOR ANALYSIS OF PHENOLS & DERIVATIVES OCCURRING IN CIGARETTE SMOKE CONDENSATES, TOBACCO PYROLYZATES OR THEIR FRACTIONS.|A SIMPLE & RAPID GAS-LIQ-SOLID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF TRACE CONCN (AT PPB LEVELS) OF 11 PHENOLS IN AIR WAS DEVELOPED. THE METHOD WAS APPLIED TO SPECIMENS OF AMBIENT AIR NEAR A PHENOLIC RESIN FACTORY & OF URBAN AIR IN NAGOYA AREA OF JAPAN.|THE SEPARATION OF 13 ISOMERIC ALKYLPHENOLS WAS STUDIED BY HIGH-PERFORMANCE LIQ, GAS-LIQ & HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHIC TECHNIQUES. THE SEPARATION OF THE ISOMERIC ALKYLPHENOLS IS PROBABLY DEPENDENT ON THE ADSORPTION, THE POLARITY OF THE SOLVENT SYSTEMS & THE CONCN OF THE CMPD WHEN USING HIGH PRESSURE LIQ CHROMATOGRAPHIC TECHNIQUE.|TRACES OF PHENOLS IN AUTO EXHAUST & TOBACCO SMOKE WERE COLLECTED BY USING A FRITTED BUBBLER WITH 10 ML OF 0.12% SODIUM HYDROXIDE SOLN AND DETERMINED BY REVERSED-PHASE HIGH-PERFORMANCE LIQ CHROMATOGRAPHY VIA DERIVATIZATION WITH P-NITROBENZENEDIAZONIUM TETRAFLUOROBORATE IN AQ MEDIUM AT PH 11.5. THE DETECTION LIMITS OF PHENOLS WERE 0.05-2.0 NG.|For more Analytic Laboratory Methods (Complete) data for 4-ETHYLPHENOL (7 total), please visit the HSDB record page.

Food additives -> Flavoring Agents|Flavoring Agents -> JECFA Flavorings Index

Flavoring Agents