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Lactulose

Lactulose structure

CAS No:
4618-18-2
Formula:
C12H22O11
Chemical Name:
Lactulose
Synonyms:
D-Fructose,4-O-β-D-galactopyranosyl-;Lactulose;Fructose,4-O-β-D-galactopyranosyl-,D-;4-O-β-D-Galactopyranosyl-D-fructose;D-Lactulose;Bifiteral;Laevolac;Isolactose;Well-me;MLS 50;Farlac;Cephulac;Generlac;Normase;Lactuflor;Duphalac;Laevilac;Milk Oligosaccharide MLP 95;Lazet;Laktusan;MLC 97;Laktulak;Vetalakt;Lael;Lactoflex;Lactofit;Prelax;Osmolak;Kristalose;Solactis galactofructose;Regulact;Milk Oligosaccharide MLS 50;576-08-9;29319-45-7;33980-82-4;40773-84-0
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Lactulose is a non-absortable sugar used in the treatment of constipation and hepatic encephalopathy. It generally begin working after eight to twelve hours but may take up to two days to improve constipation.

A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)

Lactulose Basic Attributes

Molecular Weight：

342.3

Exact Mass：

342.30

EC Number：

225-027-7

DSSTox ID：

DTXSID5045833

ATC Code：

A - Alimentary tract and metabolism

HScode：

29400090

Characteristics

PSA：

197.37000

XLogP3：

-3.21

Appearance：

White to almost white Powder

Density：

1,32g/cm

Melting Point：

169 °C

Boiling Point：

680.5±55.0 °C at 760 mmHg

Flash Point：

365.4±31.5 °C

Refractive Index：

1,45-1,47

Water Solubility：

76.4 G/100 ML (30 ºC)

Storage Conditions：

Refrigerator

Specific rotation：

-47 º (C=5, H2O, 12HR)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

LS6965000

Drug Information

MeSH：

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)

MeSH Entry Terms：

Amivalex

Lactulose Use and Manufacturing

Uses

A keto analogue of lactose.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Cosmetics -> Humectant; Skin conditioning

Computed Properties

Molecular Weight:342.30
XLogP3:-4.3
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:5
Exact Mass:342.11621151
Monoisotopic Mass:342.11621151
Topological Polar Surface Area:190
Heavy Atom Count:23
Complexity:395
Defined Atom Stereocenter Count:8
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

β-D-Fructopyranose

Drug Function and Efficacy

Lactulose is a synthetic non-absorbable disaccharide. It is not absorbed in the intestines and can be decomposed into lactic acid and acetic acid by colon bacteria, which reduces the intestinal pH value to below 6, thereby blocking the absorption of ammonia, reducing the accumulation and absorption of endotoxins, restoring the patient's blood ammonia to normal, and turning from coma to consciousness. Lactulose also has the osmotic activity of disaccharides, which can retain water and electrolytes in the intestinal cavity and produce a hypertonic effect. Therefore, it is also an osmotic laxative. Because this product is non-irritating to the intestines, it can be used to treat chronic functional constipation.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lactulose oral solution
Ingredients	The main ingredient of this product is lactulose, and its chemical name is: 4-O-β-D-galactopyranosyl-D-fructofuranosyl.
Indication	This product can cause a decrease in colonic pH, which may lead to the inactivation of colonic pH-dependent drugs (such as 5-ASA).
Specifications	100ml:50g
Manufacturer	Laiyang Jiang Bo Pharmaceutical Co., Ltd.

Lactulose oral solution
Ingredients	The main component of this product is lactulose, with the chemical name of 4-O-β-D-galactopyranosyl-D-fructofuranosyl. Molecular formula: C12H22O11, molecular weight: 342.3.
Indication	If you are taking other medicines, please consult your physician or pharmacist before using this product.
Specifications	60 ml: 40.02 g
Manufacturer	Sichuan Jianneng Pharmaceutical Co., Ltd.

Lactulose oral solution
Ingredients	The main component of this product is lactulose, with the chemical name of 4-O-β-D-galactopyranosyl-D-fructofuranosyl. Molecular formula: C12H22O11, molecular weight: 342.3.
Indication	Not yet clear.
Specifications	100 ml: 67 g

See More Related Drugs

Registered Holders

API PHARMA TECH LLC

United States
Active
FRESENIUS KABI IPSUM S.R.L.

Italy
Active
Fresenius Kabi Austria GmbH

Austria
Active

See More Registered Holders

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