4-Butoxybenzenamine
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4-Butoxybenzenamine
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CAS No:
4344-55-2
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Formula:
C10H15NO
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Chemical Name:
4-Butoxybenzenamine
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Synonyms:
Benzenamine,4-butoxy-;Aniline,p-butoxy-;4-Butoxybenzenamine;p-Butoxyaniline;4-Butoxyaniline;p-Butyloxyaniline;p-n-Butoxyaniline;(4-Butoxyphenyl)amine;4-Amino-1-butoxybenzene;NSC 5443
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CAS No:
4-Butoxybenzenamine Basic Attributes
165.236
165.23
224-402-2
P0PI549RZ4
5443
DTXSID4048199
2922299090
Characteristics
35.2
2.6
clear dark brown liquid
1.0±0.1 g/cm3
130-132 °C
143-144 °C @ Press: 12 Torr
123.6±13.1 °C
1.530
Safety Information
III
6.1
2810
3
R20/21/22;R36/37/38
S26-S28-S36/37/39-S45
BW9420000
Xn:Harmful;
P261-P280-P305 + P351 + P338
H302 + H312 + H332-H315-H319-H335
|Warning|H302 (97.73%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-Butoxybenzenamine Use and Manufacturing
General procedure: The appropriate 1-alkyloxy-4-nitrobenzene (0.0270 mol) was dissolved in 70 mL of ethanol. Tinchloride (0.119 mol) was dissolved in 30 mL of ethanol and was added dropwise. The reaction wasset to take place for two hours at 80 °C. The crude product was extracted twice in a mixture of ethylacetate/water (1:1), in which 60 g of potassium carbonate was dissolved. The organic solvent wasevaporated at reduced pressure and the product was obtained as a yellow oil. Yield ranged between65 and 85percent. 4-Butoxyaniline (3a). 1H-NMR (DMSO-d6): (δ, ppm) = 6.64 (d, 2H), 6.52 (d, 2H), 4.56 (s, 2H), 3.58 (t, 2H), 1.75(m, 2H), 1.39 (m, 2H), 0.99 (t, 3H). Yield 65percent.General procedure: These syntheses were carried out in one step as per De Marco et al. [24] Aminophenol (92 mmol) and a suspension of NaH in mineral oil (275 mmol NaH) were suspended in dry DMF (100 mL). The corresponding alkylbromide (137 mmol) was added dropwise and the mixture was then stirred for 24 h at room temperature. The reaction was quenched by adding 400 mL of distilled water and the aqueous layer was extracted with 3 × 150 mL of ethyl acetate. Collected organic layers were dried over anhydrous Na
Benzenamine, 4-butoxy-: INACTIVE
Computed Properties
Molecular Weight:165.23
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:165.115364102
Monoisotopic Mass:165.115364102
Topological Polar Surface Area:35.2
Heavy Atom Count:12
Complexity:108
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 4-Butoxybenzenamine
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InquiryUnit Price: $100 /KG EXWCAS No.: 4344-55-2Grade: Pharmaceutical GradeContent: 99%
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