Diethylene glycol monobutyl ether acetate

204.26

204.26

204-685-9

U6UTS77LXB

0789

6570|5175

DTXSID9027021

Colorless liquid

2915390090

44.8

1.1

Diethylene glycol monobutyl ether acetate is a colorless liquid with a mild odor. Floats and mixes slowly with water. (USCG, 1999)

0.985 g/cm³ @ Temp: 20 °C

-32 °C

245 °C @ Press: 760 Torr

105 °C

n20/D 1.426

Solubility in water, g/100ml at 20°C: 6.5

Store in a cool, dry place. Keep container closed when not in use.

0.04 mm Hg at 20 deg C

Relative vapour density (air = 1): 7.0

Lower flammable limit: 0.76% by volume; Upper flammable limit:5.0% by volume

Explosive limits , vol% in air: 0.6-10.7

MILD, NOT UNPLEASANT ODOR

BITTER TASTE

Henry's Law constant = 1.65X10-7 atm-cu m/mol at 25 °C (est)

1 ppm = 8.34 mg/cu m; 1 mg/L = 120 ppm|% in saturated air: less than 0.002 at 25 °C (approx)|wt/gal: 8.16 lb at 20 °C, nitrocellulose-xylene dilution ratio 1:8; coefficient of expansion 0.0010 K(+1) ... combustible|Hydroxyl radical reaction rate constant = 3.52X10-11 cu cm/molec-sec at 25 °C (est)

Water soluble.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

563 °F (USCG, 1999)|536 °F (295 °C)|290 °C

Lower flammable limit: 0.76% by volume; Upper flammable limit:5.0% by volume

NONH for all modes of transport

1

R19;R36/37

S39-S26

KJ9275000

Xi:Irritant;

Separated from strong oxidants. Ventilation along the floor.

Stable, but may be light sensitive. Combustible. Incompatible with strong oxidizing agents, acids, strong bases.

P261, P264, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, P501

H315

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Glycol ethers, glycols, ketones, and alcohols undergo violent decomposition in contact with 68-72% perchloric acid

Combustible.

|Warning|H315 (59.02%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 385 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Face shield or safety glasses; protective gloves; air mask for prolonged exposure to vapor. (USCG, 1999)

Combustible|COMBUSTIBLE WHEN EXPOSED TO HEAT OR FLAME. INCOMPATIBLE WITH OXIDIZING MATERIALS, HEAT, FLAME. .

Explosive limits , vol% in air: 0.6-10.7

FOAM, CARBON DIOXIDE, DRY CHEM...

Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Separated from strong oxidants. Ventilation along the floor. Store in an area without drain or sewer access.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is mildly irritating to the eyes and skin.

The substance defats the skin, which may cause dryness or cracking.

NO open flames.

Use ventilation.

Protective gloves.

Wear safety spectacles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Diethylene glycol monobutyl ether acetate is produced, as an intermediate or a final product, by process units covered under this subpart.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Diethyleneglycol monobutyl ether acetate has been qualitatively identified in printer's inks(1). Diethyleneglycol monobutyl ether acetate was detected but not quantified in 4 of 44 emission samples from furniture(2).

LD50 Rabbit dermal 14.8 mL/kg|LD50 rabbit dermal 5500 mg/kg|LD50 rabbit oral 2800 mg/kg|LD50 Rabbit oral 2260 mg/kg bw|For more Non-Human Toxicity Values (Complete) data for DIETHYLENE GLYCOL MONOBUTYL ETHER ACETATE (12 total), please visit the HSDB record page.

Diethyleneglycol monobutyl ether acetate's production and use as a solvent in printing inks and high-bake enamels, as a coalescing aid in latex paints, in silk screen inks, a component in polystyrene coatings for decals, a selective solvent in the separation of alcohols and ketones by distillation(1), and as a solvent for cellulose acetate, ester gum and polyvinyl acetate(2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that diethyleneglycol monobutyl ether acetate is expected to have very high mobility in soil(SRC). Volatilization of diethyleneglycol monobutyl ether acetate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.5X10-7 atm-cu m/mole(SRC) based upon its vapor pressure, 0.04 mm Hg(3), and water solubility, 31,000 mg/L(4). Diethyleneglycol monobutyl ether acetate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Diethyleneglycol monobutyl ether acetate may biodegrade quickly in soil based on four screening biodegradation studies(4-7).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that diethyleneglycol monobutyl ether acetate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 3.5X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 0.04 mm Hg(4), and water solubility, 31,000 mg/L(5). According to a classification scheme(6), an estimated BCF of 2(SRC), from an estimated log Kow of 1.30(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Diethyleneglycol monobutyl ether acetate is expected to biodegrade quickly in water based on four biodegradation studies(5,9-11).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethyleneglycol monobutyl ether acetate, which has a vapor pressure of 0.04 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethyleneglycol monobutyl ether acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hours(SRC), calculated from its rate constant of 3.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3).

The rate constant for the vapor-phase reaction of diethyleneglycol monobutyl ether acetate with photochemically-produced hydroxyl radicals has been estimated as 3.5X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.26 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 30 and 305 days at pH values of 8 and 7, respectively(2).

An estimated BCF of 2 was calculated in fish for diethyleneglycol monobutyl ether acetate(SRC), using an estimated log Kow of 1.30(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of diethyleneglycol monobutyl ether acetate can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that diethyleneglycol monobutyl ether acetate is expected to have very high mobility in soil(SRC).

The Henry's Law constant for diethyleneglycol monobutyl ether acetate is estimated as 3.5X10-7 atm-cu m/mole(SRC), derived from its vapor pressure, 0.04 mm Hg(1), and water solubility, 31,000 mg/L(2). This Henry's Law constant indicates that diethyleneglycol monobutyl ether acetate is expected to be essentially nonvolatile from water surfaces(3). Diethyleneglycol monobutyl ether acetate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

SURFACE WATER: Diethyleneglycol monobutyl ether acetate has been identified in the Rhine Delta at Maasslius at a concentration of 0.031 ug/L(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 45,220 workers (10,562 of these are female) are potentially exposed to diethyleneglycol monobutyl ether acetate in the US(1). Occupational exposure to diethyleneglycol monobutyl ether acetate may occur through inhalation and dermal contact with this compound at workplaces where diethyleneglycol monobutyl ether acetate is produced or used(SRC). Monitoring and use data indicate that the general population may be exposed to diethyleneglycol monobutyl ether acetate via inhalation of ambient air, ingestion of contaminated drinking water, and dermal contact with products containing diethyleneglycol monobutyl ether acetate(SRC).

When diethylene glycol butyl ether (DGBE) and diethylene glycol monobutyl ether acetate (DGBEA) were applied to the skin for 5 min then washed, most (90%) of the material was recovered. When applied under occlusion for 24 hr, the calculated absorption rates for DGBEA were similar (1.58, 1.28 mg/cm sq/hr for males and females, respectively; mean=1.43) to those of DGBE (0.73, 1.46; mean=1.10 mg/cm sq/hr).|DGBEA is rapidly absorbed from the gastrointestinal tract, metabolized, and excreted primarily (85% of the dose) in the urine.|14C-DGBA was rapidly absorbed from the gastrointestinal tract and eliminated predominantly in rat urine within 24 hr following oral administration at 200 or 2000 mg/kg. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. No unchanged DGBA or DGBE was detected in rat urine at either dose level.

Following dermal applications /of diethylene glycol monobutyl ether acetate/ the major urinary metabolite detected was 2-(2-butoxyethoxy) acetic acid (50-60%) with small amounts of the glucuronide conjugate of DGBE (5-8%).|The in vitro hydrolysis of diethylene glycol monobutyl ether acetate (DGBA) in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied. DGBA (5 mM) was hydrolysed in rat blood to diethylene glycol monobutyl ether (DGBE) with a half-life of less than 3 min. 14C-DGBA was rapidly absorbed from the gastrointestinal tract and eliminated predominantly in rat urine within 24 h following oral administration at 200 or 2000 mg/kg. The major urinary metabolite was 2-(2-butoxyethoxy)acetic acid. No unchanged DGBA or DGBE was detected in rat urine at either dose level.

DGBA (5 mM) was hydrolysed in rat blood to diethylene glycol monobutyl ether (DGBE) with a half-life of less than 3 min.

Prolonged breathing of vapor may cause irritation and nausea. Contact with liquid may cause mild irritation of eyes and skin. Can be absorbed through skin in toxic amounts. (USCG, 1999)

INHALATION: move victim to fresh air; if breathing has stopped, administer artificial respiration. EYES: flush with water for at least 15 min. SKIN: wash skin with large amounts of water for 15 min.; call physician if needed. INGESTION: induce vomiting; get medical attention. (USCG, 1999)

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SIGNS AND SYMPTOMS/ REPEATED AND PROLONGED CONTACT WITH THE SKIN CAUSES MILD ERYTHEMA AND EXFOLIATION IN ... HUMANS.|/CASE REPORTS/ ... 3 YR OLD CHILD ... WAS STATED ... TO HAVE DEVELOPED NEPHROSIS FROM /USE AS INSECT REPELLENT/ ... MATERIAL USED WAS KNOWN AS STA-WAY (WHICH CONTAINED 50% OF BUTYL CARBITOL ACETATE & 15% OF CARBITOL).

2-(2-butoxyethoxy)ethyl acetate

Redness. Dry skin.

Redness.

Grade: Technical

All other basic organic chemical manufacturing|Ethanol, 2-(2-butoxyethoxy)-, 1-acetate: ACTIVE|FORMERLY USED AS INSECT REPELLENT.

ESTIMATION IN ATMOSPHERE BY INFRA-RED ABSORPTION SPECTROSCOPY.|LIQ-GAS PHASE CHROMATOGRAPHY WOULD BE USEFUL IN RESOLVING MIXT, WHICH COULD THEN BE IDENTIFIED BY INFRARED OR MASS SPECTROPHOTOMETRY. /GLYCOL ETHERS/|Method: OSHA PV2095; Procedure: gas chromatography with a flame ionization detector; Analyte: butyl carbitol acetate; Matrix: air; Detection Limit: 0.06 ppm.