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Sphingosine

Sphingosine structure

CAS No:
123-78-4
Formula:
C18H37NO2
Chemical Name:
Sphingosine
Synonyms:
4-Octadecene-1,3-diol,2-amino-,(2S,3R,4E)-;4-Octadecene-1,3-diol,2-amino-,(E)-D-erythro-;4-Octadecene-1,3-diol,2-amino-,[R-[R*,S*-(E)]]-;(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol;Erythrosphingosine;D-erythro-Sphingosine;erythro-C18-Sphingosine;C18-Sphingosine;4-Sphingenine;Sphingenine;D-Sphingosine;erythro-4-Sphingenine;D-(+)-erythro-4-trans-Sphingenine;4-trans-Sphingenine;trans-4-Sphingenine;Sphingosine;D-erythro-C18-Sphingosine;(4E)-Sphingenine;(-)-D-erythro-Sphingosine;(2S,3R)-Sphingosine;(-)-Sphingosine;45261-75-4
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

White Crystalline Solidcerebroside: Any one of a class ofglycolipids in which a single sugarunit is bound to a sphingolipid. The most commoncerebrosides are galactocerebrosides,containing the sugar group galactose;they are found in the plasma membranesof neural tissue and are abundantin the myelin sheaths ofneurones.

Sphingosine Basic Attributes

Molecular Weight：

299.49

Exact Mass：

299.49

EC Number：

204-651-3

HScode：

29221985

Characteristics

PSA：

66.48000

XLogP3：

6.40

Appearance：

Solid

Density：

0.9758 (rough estimate)

Melting Point：

67 °C

Boiling Point：

440.8°C (rough estimate)

Flash Point：

223.5±28.7 °C

Refractive Index：

1.5000 (estimate)

Water Solubility：

chloroform: 20 mg/mL, clear, colorless to very faintly yellow

Storage Conditions：

-20ºC

Vapor Pressure：

7.96E-10mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

Stability/Shelf Life：

Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 90 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Sphingosine Use and Manufacturing

Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosineInhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.

Computed Properties

Molecular Weight:299.5
XLogP3:5.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:15
Exact Mass:299.282429423
Monoisotopic Mass:299.282429423
Topological Polar Surface Area:66.5
Heavy Atom Count:21
Complexity:231
Undefined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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