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2-Bromo-4-methylpyridine

2-Bromo-4-methylpyridine structure

CAS No:
4926-28-7
Formula:
C6H6BrN
Chemical Name:
2-Bromo-4-methylpyridine
Synonyms:
2-BROMO-4-PICOLINE;RARECHEMAHCK0041;-Bromo-4-methylpyridine;2-bormo-4-methylpyridine;4-Methyl-2-bromopyridine;2-BROMO-4-METHYLPYRIDINE;2-Bromo-4-MythylPyridine;2-BROMO-4-MEFHYLPYRIDINE;Pyridine,2-broMo-4-Methyl-;2--4-MethylpyridinebroMide
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Colorless to orange oily liqui

2-Bromo-4-methylpyridine Basic Attributes

Molecular Weight：

172.025

Exact Mass：

170.968353

DSSTox ID：

DTXSID00370114

HScode：

2933399090

Characteristics

PSA：

12.9

XLogP3：

1.9

Appearance：

Colorless to orange oily liquid

Density：

1.5±0.1 g/cm3

Melting Point：

218 - 228ºC

Boiling Point：

219.8°C at 760 mmHg

Flash Point：

86.7±21.8 °C

Refractive Index：

1.553

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R20/21/22;R36/37/38

safety instructions：

S26-S36-S36/37/39

Marks：

Xn:Harmful

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H302 (10.87%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Bromo-4-methylpyridine Use and Manufacturing

Methods of Manufacturing

To a solution of 2-amino-4-methylpyridine (120 g, 1.1 mol) in 48percent HBr (1.5 L) at -20° C. was added bromine (160 mL, 3.11 mol) dropwise. The reaction mixture was stirred for 3 h at -15° C. to -20° C. To the above mixture was added portionwise an aqueous solution of NaNO

Uses

An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity

Computed Properties

Molecular Weight:172.02
XLogP3:1.9
Hydrogen Bond Acceptor Count:1
Exact Mass:170.96836
Monoisotopic Mass:170.96836
Topological Polar Surface Area:12.9
Heavy Atom Count:8
Complexity:74.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 4926-28-7

Content: 99%

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Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
4 YRS

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2-Bromo-4-methylpyridine 99%

CAS No.: 4926-28-7

Content: 99%

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