 Home > Encyclopedia > 1-Monostearin

1-Monostearin

1-Monostearin structure

CAS No:
123-94-4
Formula:
C21H42O4
Chemical Name:
1-Monostearin
Synonyms:
Octadecanoic acid,2,3-dihydroxypropyl ester;Stearin,1-mono-;Aldo 33;Aldo 75;Glycerol α-monostearate;α-Monostearin;1-Monostearin;Stearic acid 1-monoglyceride;Glycerin 1-monostearate;1-Monostearoylglycerol;Glycerol 1-monostearate;Glyceryl 1-monostearate;Sandin EU;Glycerin 1-stearate;1-Glyceryl stearate;Tegin 55G;Emerest 2407;Aldo MSD;Aldo MSLG;Glycerol 1-stearate;Stearic acid α-monoglyceride;3-Stearoyloxy-1,2-propanediol;1-Monooctadecanoylglycerol;2,3-Dihydroxypropyl octadecanoate;(±)-2,3-Dihydroxypropyl octadecanoate;1-monostearoyl-rac-glycerol;Glyceryl 1-octadecanoate;NSC 3875;AS 8 (surfactant);2,3-Dihydroxypropyl stearate;1-Stearoyl-rac-glycerol;1-Monostearoyl-rac-glycerol;22610-63-5;342394-34-7
Categories:
Organic Chemistry > Carboxylic Acids and Derivatives

Description

ChEBI: A rac-1-monoacylglycerol composed of equal amounts of 3-stearoyl-sn-glycerol and 1-stearoyl-sn-glycerol.Monostearin (also known as 1-Stearoyl-rac-glycerol) is a long chain molecule typically occurring in the body as a by-product of the breakdown of fats. It is one of the panels of serum metabolic biomarkers for detecting and diagnosing cancer, especial ovarian cancer. It is also used in the development of drug delivery vehicles such as nanoparticles and microemulsions. It can also be

DryPowder; DryPowder, OtherSolid, Liquid; Liquid; PelletsLargeCrystals|white to pale yellow wax-like solid with a mild fatty odour

1-monostearoylglycerol is a 1-monoglyceride that has stearoyl as the acyl group. It has a role as an algal metabolite and a Caenorhabditis elegans metabolite.|Glycerol monostearate, commonly known as GMS, is the glycerol ester of stearic acid . It is commonly used as an emulsifier in foods.

1-Monostearin Basic Attributes

Molecular Weight：

358.55600

Exact Mass：

358.56

EC Number：

500-265-7

NSC Number：

3875

DSSTox ID：

DTXSID7027968|DTXSID7029160

HScode：

2915709000

Characteristics

PSA：

66.76000

XLogP3：

5.1443

Appearance：

Colorless, non - smelling, and sweet - like powder

Density：

0.9678 g/cm³ @ Temp: 20 °C

Melting Point：

40.5 °C

Boiling Point：

476.9ºC at 760 mmHg

Flash Point：

151.9ºC

Water Solubility：

insoluble in water; soluble in hot oils, organic solvents

Storage Conditions：

-20ºC

Safety Information

wgk germany：

safety instructions：

24/25

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

GHS Classification：

Not Classified

Drug Information

MeSH Entry Terms：

glyceryl monostearate

1-Monostearin Use and Manufacturing

Methods of Manufacturing

1、esterificated from glycerin and Stearic acid.put Stearic acid, glycerol and sodium hydroxide into the reaction pot, after heating and stirring, started to stirring and then put nitrogen through it , heat and reaction at 185℃ for 7 hours , after the reaction , the PH should be less than 5 .then cool down and get the Glycerol monostearate.Per ton of production use more than 82kg Stearic acid and glycerin(95%) 235kg .
2、Direct esterification : Stearic acid and glycerol according to 1: (1.2 - 1.3), with 0.2% acidic catalyst , reaction 2-4hours at 180-250℃, then cooled rapidly to 100 ℃, put base to neutralized the catalyst.After washing with water get the product contain 40%～60% monoester.
Transesterification:Glyceryl stearate and the glycerin under the presence of 0.06%～0.1% Cu(OH)2 react 1-2 hours at 170-240℃, During the reaction, nitrogen gas was introduced for protection, The reactants are deodorized under reduced pressure, acidified and refined to obtain products containing 40% to 60% of monoesters. Saponification of glycidol:Glycidol and stearic acid under the catalysis of tetraethylammonium iodide, react 30-70min at 100～130℃ after refining , The reactants can be changed to 80% to 90% of monoester products.Epichlorohydrin Phase Transfer Catalysis:Epichlorohydrin and sodium stearate (2: 1 mol ratio)in the toluene catalyzed by tetrabutylammonium bromide as a phase transfer catalyst react 2h at 90～110℃ .The reaction was washed with sodium chloride solution , separat the organic phase distillat to remove the toluene and unreacted epichlorohydrin to get Glycidyl stearate , and then hydrolyzed with 0.1 mol / L NaOH solution, After separation, drying, with n-hexane recrystallization to get the products.Monoester content is more than 90% .the products which contain 40% to 60% of the single ester could change to more than 90% of the high concentration of products after the molecular distillation.

Uses

1. Labelled 1-Stearoyl-rac-glycerol, one of the panels of serum
2. Used in the development of drug delivery vehicles such as nanoparticles and microemulsions

Emulsifier

Building/construction materials not covered elsewhere

Production

1,000,000 - 10,000,000 lb

Manufacturing Info：

All other chemical product and preparation manufacturing|Octadecanoic acid, monoester with 1,2,3-propanetriol: ACTIVE|Octadecanoic acid, 2,3-dihydroxypropyl ester: ACTIVE|1,2,3-Propanetriol, homopolymer, isooctadecanoate: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Use Classification：

EPA Safer Chemical Functional Use Classes -> Surfactants|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Lipids -> Glycerolipids [GL] -> Monoradylglycerols [GL01] -> Monoacylglycerols [GL0101]|Cosmetics -> Emollient; Emulsifying

Food Additive Classes：

Flavoring Agents

Computed Properties

Molecular Weight:358.6
XLogP3:7.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:20
Exact Mass:358.30830982
Monoisotopic Mass:358.30830982
Topological Polar Surface Area:66.8
Heavy Atom Count:25
Complexity:281
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Toluene

Adipic acid

Sodium hydroxide

Glycerol

Stearic acid

Price Analysis

Make your 1-Monostearin purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on 1-Monostearin prices .

Related Drugs

Sanwei Fubao Ointment
Ingredients	Astragalus, refined aloe vera, American ginseng, auxiliary ingredients are stearic acid, monoglyceride, stearyl alcohol, vaseline, essence, kasonon, and paraben.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each pack contains 15g; 35g; 50g

Recommended Suppliers of 1-Monostearin

LEADER BIOCHEMICAL GROUP Contact Supplier

CN
8 YRS

Business licensed Certified factory

Manufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances Chemicals

China Most Professional Factory Supply High Qulity Glycery monostearate/Monostearin/Distilled glycerin monostearate CAS 123-94-4

CAS No.: 123-94-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Mudanjiang Fengda Chemicals Imp.& Exp. Corp. Contact Supplier

CN
10 YRS

Business licensed

Trader Supplier of oxalic acid,formic acid,calcium formate,sodium formate,humic acid,sodium humate

Industrial Food Grade 123-94-4 GMS 90 Powder Price Glyceryl Monostearate

Unit Price: $1270-1651 /MT FOB

CAS No.: 123-94-4

Grade: Food Grade

Content: 60%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high purity PET Resin 99% high quality see COA KANBEI

CAS No.: 123-94-4

Grade: Industrial Grade

Content: 99%

Inquiry
BLUENOTE TRADING LLC Contact Supplier

US
4 YRS

Business licensed

Trader Supplier of Fertilizer,Food Additives,Water Chemicals,Industrial Chemicals,Solvents,Minning Chemicals

Distilled Monoglyceride(DMG) 99% 99% Powder 99%

CAS No.: 123-94-4

Grade: Food Grade

Content: 99%

Inquiry
Hangzhou Fuchun Food Additive Co., Ltd Contact Supplier

CN
10 YRS

Business licensed Certified factory

Manufactory Supplier of Distilled Monoglyceride, Glycerol Monostearate GMS

Glycerol Monostearate 40%

CAS No.: 123-94-4

Grade: Industrial Grade

Content: 40%

Inquiry