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Naphtho[1,2-d]thiazol-2-amine

Naphtho[1,2-d]thiazol-2-amine structure

CAS No:
40172-65-4
Formula:
C11H8N2S
Chemical Name:
Naphtho[1,2-d]thiazol-2-amine
Synonyms:
Naphtho[1,2-d]thiazol-2-amine;Naphtho[1,2-d]thiazole,2-amino-;α-Naphthothiazole,1-amino-;2-Aminonaphtho[1,2-d]thiazole;2-Aminonaphthiazole;NSC 6278;SKA 31
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure[1].

Naphtho[1,2-d]thiazol-2-amine Basic Attributes

Molecular Weight：

200.26

Exact Mass：

200.26

EC Number：

254-822-1

UNII：

SW12CAS9T7

NSC Number：

6278

DSSTox ID：

DTXSID2068216

HScode：

2934999090

Characteristics

PSA：

67.2

XLogP3：

3.61290

Density：

1.403g/cm3

Melting Point：

235-237 °C

Boiling Point：

417.1ºC at 760 mmHg

Flash Point：

206.1ºC

Refractive Index：

1.83

Water Solubility：

DMSO: ≥30mg/mL

Storage Conditions：

Store at +4°C

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

20/21/22-36/37/38-36-22

safety instructions：

22-36/37/39-26

Marks：

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H302-H319

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

naphtho(1,2-d)thiazol-2-ylamine

Naphtho[1,2-d]thiazol-2-amine Use and Manufacturing

Manufacturing Info：

Naphtho[1,2-d]thiazol-2-amine: INACTIVE

Computed Properties

Molecular Weight:200.26
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:200.04081944
Monoisotopic Mass:200.04081944
Topological Polar Surface Area:67.2
Heavy Atom Count:14
Complexity:221
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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2-AMINO-BETA-NAPHTHOTHIAZOLE

CAS No.: 40172-65-4

Content: 99.00%

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Guide of Naphtho[1,2-d]thiazol-2-amine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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