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2-Iodo-3-pyridinol

2-Iodo-3-pyridinol structure

CAS No:
40263-57-8
Formula:
C5H4INO
Chemical Name:
2-Iodo-3-pyridinol
Synonyms:
3-Pyridinol,2-iodo-;2-Iodo-3-pyridinol;2-Iodo-3-hydroxypyridine;3-Hydroxy-2-iodopyridine;NSC 103161;37352-60-6
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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2-Iodo-3-pyridinol Basic Attributes

Molecular Weight：

221

Exact Mass：

221.00

BRN：

109836

EC Number：

254-864-0

NSC Number：

103161

DSSTox ID：

DTXSID50193254

HScode：

2933399090

Characteristics

PSA：

33.1

XLogP3：

1.2

Appearance：

White to tan Crystalline Powder

Density：

2.1±0.1 g/cm3

Melting Point：

192 °C @ Solvent: Benzene

Boiling Point：

296.6°C at 760 mmHg

Flash Point：

133.2±21.8 °C

Refractive Index：

1.683

Water Solubility：

Slightly soluble in water.

Storage Conditions：

Room temperature.

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-41-37/38-22

safety instructions：

26-36-39

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H318-H335

GHS Classification：

|Danger|H302 (86.36%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Iodo-3-pyridinol Use and Manufacturing

To a solution of 3-hydroxypyridine 4 (5.0 g, 52.57 mmol) in water (400 mL) was added Na3-hydroxypyridine (20.0 g, 0.21 mol) was added to a three-necked flaskAnd water (1600 mL); add sodium carbonate at room temperature(46.4 g, 0.44 mol) and elemental iodine (53.2 g, 0.21 mol), Stir at room temperature for 2 hours. Adjust pH = 4 with 1 N hydrochloric acidA lot of solids precipitated, filtered, Compound 1 (41.9 g, 0.19 mol, 90percent) was dried.To a stirring solution of 3-hydroxy pyridine (30 g, 315.78 mmol) in water (3000 mL) was added Na2CO3 (70 g, 663.15 mmol) followed by Iodine (80 g, 315.78 mmol) in portion wise at 0 °C. The reaction mixture was allowed to stir at room temperature for 2 hrs. Reaction mass was acidified with iN HC1 up to pH -4 to get the solid which was filtered off, washed with chilled water followed by MTBE-Hexane to afford desired 3-hydroxy-2-iodopyridine (45 g) as off white solid.

Computed Properties

Molecular Weight:221.00
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:220.93376
Monoisotopic Mass:220.93376
Topological Polar Surface Area:33.1
Heavy Atom Count:8
Complexity:78.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Manufactory Supplier of 5 Bromo 2 chloropyrimidine

2-IODO-3-HYDROXYPYRIDINE

CAS No.: 40263-57-8

Grade: Industrial Grade

Content: 97%

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