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Atropine sulfate

Atropine sulfate structure

CAS No:
55-48-1
Formula:
C17H23NO3.¹/2H2O4S
Chemical Name:
Atropine sulfate
Synonyms:
Benzeneacetic acid,α-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,sulfate (2:1);1αH,5αH-Tropan-3α-ol (±)-tropate (ester),sulfate (2:1) (salt);Benzeneacetic acid,α-(hydroxymethyl)- 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(±)-,sulfate (2:1) (salt);Benzeneacetic acid,α-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,sulfate (2:1) (salt);Atropine sulfate;Atropine sulphate;Atropisol;Atropinium sulfate;Atropisal;MBK;Ichtho-Bellol;Atropette;Atropinsal;Sulfatropinol;Tropintran;Corbella;Davurtrop;Eyesule;Lio-Atropin;Benzeneacetic acid,α-(hydroxymethyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-,sulfate (2:1) (salt);Atropisol Ophthalmic Solution;NSC 26671;Atropine Minims;Isopto Atropine;17108-73-5
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Atropine sulfate is a competitive muscarinic acetylcholine receptor antagonist.IC50 value:Target: mAChRAtropine is a naturally occurring tropane alkaloid extracted from deadly nightshade (Atropa belladonna), Jimson weed (Datura stramonium), mandrake (Mandragora officinarum) and other plants of the family Solanaceae. Atropine is a competitive antagonist of the muscarinic acetylcholine receptors (acetylcholine being the main neurotransmitter used by the parasympathetic nervous system). Atr

The 3(S)-endo isomer of atropine.

Atropine sulfate Basic Attributes

Molecular Weight：

676.82

Exact Mass：

676.302967

EC Number：

200-235-0

DSSTox ID：

DTXSID3040724

HScode：

2933990090

Characteristics

PSA：

182.52000

XLogP3：

4.16560

Density：

1.1172 (rough estimate)

Melting Point：

50.5 °C

Boiling Point：

135 °C

Flash Point：

213.7ºC

Storage Conditions：

0-6°C

Toxicity：

Oral-rat LD50: 600 mg/kg; Oral-Mouse LD50; 468 mg/kg

Flammability characteristics：

Combustible; Combustion produces toxic nitrogen oxides and sulfur oxide fumes; Patient side effects: Plasma at body temperature; Arrhythmia

Safety Information

Transport codes：

UN 1544 6.1/PG 2

wgk germany：

hazard class code：

26/28

safety instructions：

23-45

Marks：

T+

Storage features：

Ventilated, low temperature and dry; stored separately from food materials in warehouse

GHS Classification：

|Danger|H300 (50%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P271, P284, P301+P310, P301+P312, P304+P340, P310, P320, P321, P330, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (See all compounds classified as Adjuvants, Anesthesia.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)|Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)|Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

Anaspaz

Atropine sulfate Use and Manufacturing

cholinergic receptor antagonist

Computed Properties

Molecular Weight:387.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:387.13517331
Monoisotopic Mass:387.13517331
Topological Polar Surface Area:133
Heavy Atom Count:26
Complexity:434
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Belladonna alkaloid, anticholinergic/antimuscarinic; inhibits muscarinic actions of acetylcholine, reduces muscle spasms and glandular secretions.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

PHENOHYTRO- phenobarbital, hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide_elixir
Manufacturer	ATLANTIC BIOLOGICALS CORP.

Registered Holders

CURIA WISCONSIN INC

United States
Active
SCL LIFESCIENCES LTD

United States
Active
MATRIX PHARMACORP PRIVATE LTD

United States
Active

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