 Home > Encyclopedia > 2-(2-Aminoethyl)isothiourea dihydrobromide

2-(2-Aminoethyl)isothiourea dihydrobromide

2-(2-Aminoethyl)isothiourea dihydrobromide structure

CAS No:
56-10-0
Formula:
C3H11Br2N3S
Chemical Name:
2-(2-Aminoethyl)isothiourea dihydrobromide
Synonyms:
s-(beta-aminoethyl)isothiuroniumbromidehydrobromide;s-aminoethylisothiuroniumbromidehydrobromide;s-beta-aminoethylisothiuroniumbromohydrate;surrectan;usafxr-31;(2-aminoethyl)-2-thio-pseudouredihydrobromide;2-(2-aminoethyl)-2-thiopseudoureahydrobromide;2-(beta-aminoethyl)isothiouroniumbromidehydrobromide
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Crystals, hygroscopic.

A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.

S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Kivalues are 1.8, 2.1, and 0.59 μM, respectively.

Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957].

2-(2-Aminoethyl)isothiourea dihydrobromide Basic Attributes

Molecular Weight：

281.01

Exact Mass：

278.904022

BRN：

3911163

EC Number：

200-257-0

UNII：

03K18418PY

TSCA：

TSCA listed

DSSTox ID：

DTXSID1058765

Color/Form：

White to Almost white

HScode：

2930 90 98

Characteristics

PSA：

101.19000

XLogP3：

2.98830

Density：

1.94 g/cm3

Melting Point：

190-196 °C(lit.)

Boiling Point：

231.1ºC at 760mmHg

Flash Point：

93.6ºC

Water Solubility：

almost transparency

Storage Conditions：

Store below +30°C.

Toxicity：

LD50 in mice (mg/kg): 100 i.v., 280 s.c., 480 i.p., 1600 orally (Pospisil)

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides, hydrogen bromide and sulfur oxide fumes

Critical Temperature & Pressure：

Store below +30°C.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

26-36/37-22

RTECS Number：

UM0175000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

22-36/37/38

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other purposes, e.g. military. (See all compounds classified as Radiation-Protective Agents.)

MeSH Entry Terms：

2 Aminoethylisothiuronium Bromide

2-(2-Aminoethyl)isothiourea dihydrobromide Use and Manufacturing

Uses

NOS inhibitor

2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).

Has radioprotective activity against x-rays.

Manufacturing Info：

Carbamimidothioic acid, 2-aminoethyl ester, hydrobromide (1:2): ACTIVE

Computed Properties

Molecular Weight:281.02
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:280.90199
Monoisotopic Mass:278.90404
Topological Polar Surface Area:101
Heavy Atom Count:9
Complexity:63.2
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Material

Ethanolamine

Drug Function and Efficacy

This product is a drug that promotes the metabolism of central nervous cells. Its mechanism of action is that the active thiol groups released in the body participate in the redox process of brain cells, thereby promoting and restoring the metabolism of brain cells and quickly restoring metabolic function. In addition, it also has the effect of counteracting central nervous system drugs.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ethylaminethiocarbamide for injection
Ingredients	Ethylaminethiourea
Indication	This product has the effect of resisting chlorpromazine drugs.
Specifications	0.5g
Manufacturer	Shanxi PUDE Pharmaceutical Co., Ltd.

Ethylaminethiourea
Manufacturer	Hainan General Alliance Pharmaceutical Co., Ltd.

Ethylaminethiocarbamide for injection
Ingredients	Ethylaminethiourea
Indication	This product has the effect of resisting chlorpromazine drugs.
Specifications	0.25g

See More Related Drugs

Registered Holders

Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

China
Active
Jiuquan Dadeli Pharmaceutical Co., Ltd.

China
Active
Hainan General Alliance Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of 2-(2-Aminoethyl)isothiourea dihydrobromide

Shenyang NewCathayone Tech Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Fosfomycin

NewCathayone 2-(2-Aminoethyl)Isothiourea Dihydrobromide

CAS No.: 56-10-0

Inquiry

Latest News on 2-(2-Aminoethyl)isothiourea dihydrobromide

Learn More Other Chemicals

1-(2-Aminoethyl)-1H-imidazole dihydrobromide

167298-66-0
Carbamimidothioic acid, 2-[(aminoiminomethyl)amino]ethyl ester, dihydrobromide

100130-32-3
4-(5-AMINOPENTYL)IMIDAZOLE DIHYDROBROMIDE

149629-70-9
IEM 1754 dihydrobroMide Formula

162831-31-4
1,4-Bis(1-aziridinyl)-2,3-butanedione-d8 DihydrobroMide Formula

1329485-50-8
1-(2-BROMOETHYL)PIPERAZINE DIHYDROBROMIDE Formula

89727-93-5
BD 1008 Dihydrobromide Structure

138356-09-9
1-(3H-imidazol-4-yl)propan-2-amine dihydrobromide Structure

28814-35-9
What is L-Cystine, bis[2,2-bis(2-chloroethyl)hydrazide], dihydrobromide

53317-25-2
What is alpha,alpha'-Bis(4-aminobutyl)-1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-N,N'-bis(tricyclo(3.3.1.1(3,7))dec-1-yl)benzo(lmn)(3,8)phenanthroline-2,7-diacetamide dihydrobromide

81253-96-5

Hot Searches: biotrend corporation; wood creosote; can you purchase formaldehyde; 13x zeolite; retatrutide purchase online; phosphorus pentoxide sds

Guide of 2-(2-Aminoethyl)isothiourea dihydrobromide

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

2-(2-Aminoethyl)isothiourea dihydrobromide

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.