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Home > Encyclopedia > Benactyzine hydrochloride

Benactyzine hydrochloride

pharmaceutical raw materials
Benactyzine hydrochloride structure

Benactyzine hydrochloride 

structure
  • CAS No:

    57-37-4

  • Formula:

    C20H25NO3.ClH

  • Chemical Name:

    Benactyzine hydrochloride

  • Synonyms:

    Benzeneacetic acid,α-hydroxy-α-phenyl-,2-(diethylamino)ethyl ester,hydrochloride (1:1);Benzilic acid,2-(diethylamino)ethyl ester hydrochloride;Benzeneacetic acid,α-hydroxy-α-phenyl-,2-(diethylamino)ethyl ester,hydrochloride;Ethanol,2-diethylamino-,benzilate-HCl;AY 5406-1;Amisyl;Amizyl;Amyzyl;Benactyzine hydrochloride;Cafron;Cevanol;β-Diethylaminoethyl benzilate hydrochloride;2-Diethylaminoethyl benzilate hydrochloride;2-Diethylaminoethyl diphenylglycolate hydrochloride;Lucidil;Nervacton;Nutinal;Parasan;Parpon;Phobex;Suavitil;Amizil;Benactyzine chloride;Aktozin;Amitakon;Arkadin;Benaktin;Valladon;Katron;Leucidil;Neuraktil;Neurobenzil;Nervatil;Parazan;Prokalm;Stoikon;Tranquillin;Fobex;Cedad;AY 5406;Destendo;Valladan;Procalm;Win 5606;Ibiotyzil;Arcadine;Neuroleptone;Actozine;2702-56-9

  • Categories:

    Active Pharmaceutical Ingredients  >  Digestive System Drugs

Description

Benactyzine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with a Ki of 0.010 mM.


A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.

Benactyzine hydrochloride Basic Attributes

363.88

363.160126

200-324-4

26R628272Q

16339

DTXSID8052774

Characteristics

49.8

3.60950

1.115g/cm3

177-178 °C

409.3ºC at 760mmHg

201.4ºC

>54.6 [ug/mL]

Oral-rat LD50; 184 mg/kg; Oral-Mouse LD50: 160 mg/kg

Combustion produces toxic nitrogen oxides and hydrogen chloride fumes; very small amounts can cause mental disturbance

Safety Information

III

6.1(b)

UN 2811 6.1/PG 3

3

23/24/25

36/37/39-45

DD2800000

T

Ventilated, low temperature and dry; stored separately from food materials in warehouse

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, P501

H301

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

highly toxic

Drug Information

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)|Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

Amizil

Benactyzine hydrochloride Use and Manufacturing

Uses

Benactyzine is an antagonist of acetylcholine in the central and peripheral nervous system. Benactyzine is used as an antispasmodic.

Benzeneacetic acid, .alpha.-hydroxy-.alpha.-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride (1:1): INACTIVE

Computed Properties

Molecular Weight:363.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:363.1601214
Monoisotopic Mass:363.1601214
Topological Polar Surface Area:49.8
Heavy Atom Count:25
Complexity:351
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • China Resources Double-Crane Pharmaceutical Co., Ltd.

    China China
    Active
  • GANE AND INGRAM INC

    United States United States
    Inactive

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