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(±)-Methionine

(±)-Methionine structure

CAS No:
59-51-8
Formula:
C5H11NO2S
Chemical Name:
(±)-Methionine
Synonyms:
Methionine;Methionine,DL-;DL-Methionine;α-Amino-γ-methylmercaptobutyric acid;DL-2-Amino-4-(methylthio)butyric acid;Banthionine;Cynaron;Dyprin;Lobamine;Meonine;Methilanin;Metione;Neston;(±)-Methionine;Racemethionine;Lactet;Pedameth;Urimeth;Amurex;NSC 9241;Meprom M 85;Rhodimet NP 99;Smartamine M;Smartamine;Timet;MetAMINO;MetiPEARL;Acimetion;2-Amino-4-(methylthio)butanoic acid;2-Amino-4-(methylsulfanyl)butanoic acid;2-Azaniumyl-4-methylsulfanylbutanoate;DL-Methionine;1105707-18-3;192948-75-7
Categories:
Cosmetic Ingredient > Antistatic

Description

White crystalline powder White, crystalline platelets or powder having a characteristic odor.One g dissolves in about 30 mL of water. It is soluble in dilute acids and in solutions of alkali hydroxides. It is very slightly soluble in alcohol, and practically insoluble in ether. It is optically inactive. The pH of a 1 in 100 solution is between 5.6 and 6.1. This substance may be prepared by addition of methanethiol to acrolein; by chemical conversion of methylthiopropionic aldehyde. d,l-

Solid|COLOURLESS CRYSTALS OR WHITE POWDER.|White crystalline platelets or powder; Characteristic aroma

Methionine is a sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4. It has a role as an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite, a Daphnia magna metabolite and an algal metabolite. It is an alpha-amino acid and a sulfur-containing amino acid. It derives from a butyric acid. It is a conjugate base of a methioninium. It is a conjugate acid of a methioninate. It is a tautomer of a methionine zwitterion.|A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers.|A sulfur-containing essential L-amino acid that is important in many body functions.

(±)-Methionine Basic Attributes

Molecular Weight：

149.21

Exact Mass：

149.21

BRN：

636185

EC Number：

200-432-1

ICSC Number：

0919

NSC Number：

522406|118113|45689|22946|9241

DSSTox ID：

DTXSID9020821

ATC Code：

V - Various

HScode：

29304090

Characteristics

PSA：

88.6

XLogP3：

-1.9

Appearance：

White Crystals or Crystalline Powder

Density：

1.3 g/cm³

Melting Point：

281 °C (decomp)

Boiling Point：

181 deg C (decomposes)

Flash Point：

139.4±26.5 °C

Refractive Index：

1.531

Water Solubility：

H2O: 2.9 g/100 mL (20 ºC);1 M HCl: 0.5 M at 20 °C, clear, colorless

Storage Conditions：

0-6°C

Vapor Pressure：

8.14X10-8 mm Hg at 25 deg C (est)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

33-36/37/38

safety instructions：

24/25-36-26

RTECS Number：

PD0457000

Marks：

Storage features：

Separated from strong oxidants. Well closed.

Stability/Shelf Life：

Stable. Incompatible with strong oxidising agents.

Fire Hazards：

Gives off irritating or toxic fumes (or gases) in a fire.

GHS Classification：

Not Classified

Fire Fighting：

Use water spray, powder, foam, carbon dioxide.

Spillage Disposal：

Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Safe Storage：

Separated from strong oxidants. Well closed.

Inhalation Prevention：

Use local exhaust.

Eye Prevention：

Wear safety spectacles.

Drug Information

Drug Indication：

Parenteral nutrition

First Aid：

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

MeSH Entry Terms：

L-Isomer Methionine

Exposure Routes：

The substance can be absorbed into the body by ingestion.

(±)-Methionine Use and Manufacturing

Methods of Manufacturing

Generally, a synthesis method using acrolein as a raw material is adopted. Acrylic aldehyde and methyl mercaptan are condensed in the presence of formic acid and copper acetate to form 3-methylthiopropanal. Mix with sodium cyanide and ammonium bicarbonate solution. Reaction at 90°C yields methylthioethylhydantoin. Without separation and purification, it can be heated to 180°C with 28% sodium hydroxide solution to hydrolyze to produce sodium methionine. Neutralize with hydrochloric acid to get finished methionine. Each ton of product consumes 480kg of acrolein, 400kg of methyl mercaptan, and 420kg of sodium cyanide.

Uses

An essential nonpolar amino acid with oxidative stress defense properties.DL-methionine can be used as a nutritional supplement.Feed nutrition enhancer.Biochemical research; used for the cultivation of mammalian and insect cells where mixed isomers are marked

Manufacturing Info：

Methionine: ACTIVE

Use Classification：

EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Food additives -> Flavoring Agents|Human Drugs -> EU pediatric investigation plans|Flavoring Agents -> JECFA Flavorings Index|Cosmetics -> Antistatic; Hair conditioning; Skin conditioning

Food Additive Classes：

Flavoring Agents

Computed Properties

Molecular Weight:149.21
XLogP3:-1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:149.05104977
Monoisotopic Mass:149.05104977
Topological Polar Surface Area:88.6
Heavy Atom Count:9
Complexity:97
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ammonium bicarbonate

2-Methoxyethanol

Hydrochloric acid

Downstream Products

Glycolic acid

Drug Function and Efficacy

One of the eight essential amino acids for the human body, it combines with ATP to generate S-adenosine, promotes methylation of liver cell membrane phospholipids, reduces intrahepatic bile stasis, strengthens transsulfurization, restores normal physiological functions of liver cells, promotes the disappearance of jaundice and recovery of liver function, supplies methyl to promote choline synthesis, promotes liver fat metabolism, protects the liver and detoxifies.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Methionine Vitamin B1 Injection
Ingredients	This product is a compound preparation, its components are: methionine and vitamin B1.
Indication	When used in pre-cirrhotic and cirrhotic patients with elevated blood ammonia, blood ammonia levels should be carefully monitored.
Specifications	5ml: methionine 100mg and vitamin B1 10mg
Manufacturer	Jiangsu Langou Pharmaceutical Co., Ltd.

Compound Amino Acid Injection (15AA)
Ingredients	This product is a compound preparation, and its components are as follows: Each 1000ml contains L-isoleucine 7.66g L-valine 8.86g L-leucine 13.78g L-alanine 4g L-lysine 4.1g L-arginine 5.8g (lysine acetate 5.8g) L-histidine 1.6g methionine 2.50g L-serine 3.3g L-phenylalanine 3.20g L-proline 6.3g L-threonine 2g glycine 3.3g<br/
Indication	Not yet clear.
Specifications	100 ml: 8 g (total amino acids)
Manufacturer	Chengdu Brilliant Pharmaceutical Co., Ltd.

Compound Amino Acid Injection (15AA)
Ingredients	This product is a compound preparation, and its components are as follows: Each 1000ml contains L-isoleucine 7.66g L-valine 8.86g L-leucine 13.78g L-alanine 4g L-lysine 4.1g L-arginine 5.8g (lysine acetate 5.8g) L-histidine 1.6g methionine 2.50g L-serine 3.3g L-phenylalanine 3.20g L-proline 6.3g L-threonine 2g glycine 3.3g<br/
Indication	Not yet clear.
Specifications	250 ml: 20 g (total amino acids)

See More Related Drugs

Registered Holders

Yuanda Bafeng (Hubei) Pharmaceutical Co., Ltd.

China
Active
Zhangjiagang Huachang Pharmaceutical Co., Ltd.

China
Active
Jinyao Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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