Zinc phenolsulfonate

411.72

409.910858

204-867-8

4O71YT5YB5

2813|3077

DTXSID1059571

Colorless transparent crystals or white granular powder

171.62000

2.75170

Zinc phenolsulfonate appears as a colorless to white crystalline solid which turns pink on exposure to air. The primary is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is soluble in water. It is used as an insecticide and in medicine.

greater than 1 at 68° F (USCG, 1999)

248° F at 760 mm Hg (decomposes) (USCG, 1999)

Solubility: 62.5 g/100 cc cold water; 250 g/100 cc water at 100 °C; 55.6 g/100 cc alcohol at 25 °C /Octahydrate/

Storage temp: ambient

Odorless

Moderate acidity

SPECIFIC GRAVITY: GREATER THAN 1 @ 20 °C /OCTAHYDRATE/

Soluble in water. Turns pink on exposure to air.

Phenols and Cresols

ZINC PHENOLSULFONATE behaves as a weak acid in solution. Therefore, it would react with bases in neutralization reactions that would generate heat.

3077

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

H302

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Zinc and Health. Current Bibliographies in Medicine 98-3. Public Services Division/National Library of Medicine. 3619 citations January, 1990-June, 1998. Available from: http://www.nlm.nih.gov/archive/20040831/pubs/cbm/zinc.html as of November 2, 1998.|USEPA; Ambient Water Quality Criteria Doc: Zinc (1980) EPA 400/5-80-079|USEPA; Ambient Water Quality Criteria Doc: Zinc (1987) EPA 400/5-87-003|Arvidson, B. A Review of Axonal Transport of Metals. Toxicology 88: 1-14 (19994) Recent findings regarding axonal transport of metals, including zinc.|For more Special Reports (Complete) data for ZINC PHENOLSULFONATE (6 total), please visit the HSDB record page.

Special Hazards of Combustion Products: Irritating oxides of sulfur may form in fires. (USCG, 1999)

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 76 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 138 [Substances - Water-Reactive (Emitting Flammable Gases)]: DO NOT USE WATER OR FOAM. SMALL FIRE: Dry chemical, soda ash, lime or sand. LARGE FIRE: DRY sand, dry chemical, soda ash or lime or withdraw from area and let fire burn. Move containers from fire area if you can do it without risk. FIRE INVOLVING METALS OR POWDERS (ALUMINUM, LITHIUM, MAGNESIUM, ETC.): Use dry chemical, DRY sand, sodium chloride powder, graphite powder or Met-L-X® powder; in addition, for Lithium you may use Lith-X® powder or copper powder. Also, see ERG Guide 170. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)

Excerpt from ERG Guide 138 [Substances - Water-Reactive (Emitting Flammable Gases)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 138 [Substances - Water-Reactive (Emitting Flammable Gases)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch or walk through spilled material. Stop leak if you can do it without risk. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. DO NOT GET WATER on spilled substance or inside containers. SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Dike for later disposal; do not apply water unless directed to do so. POWDER SPILL: Cover powder spill with plastic sheet or tarp to minimize spreading and keep powder dry. DO NOT CLEAN-UP OR DISPOSE OF, EXCEPT UNDER SUPERVISION OF A SPECIALIST. (ERG, 2016)

Dust mask; goggles or face shield; protective gloves (USCG, 1999)|/NIOSH certified respirator/; goggles or face shield; protective gloves. /Octahydrate/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

LD50 Oral Rat 1800 mg/kg|LD50 Oral Mouse 3 g/kg|LD50 ip Mouse 225 mg/kg

Use of zinc phenolsulfonate in therapeutic applications will result in considerable human exposure. (SRC)

Several zinc (Zn) salts gave a concn dependent inhibition of human plaque growth in vitro. The effectiveness of the treatment was reduced by increasing the time allowed for growth after the final application of Zn. Use of Zn phenolsulfonate in mouthwash resulted in a 30% reduction in the extension of plaque along the gingival margin in vivo over 16 hr.|MEDICATION (VET): HAS BEEN USED AS INTESTINAL ANTISEPTIC, & EXTERNALLY TO PROMOTE HEALING OF ULCERS, SLOWLY GRANULATING WOUNDS|FORMERLY USED AS INTESTINAL ANTISEPTIC IN DOSES OF 60 TO 200 MG. IN LARGE DOSES IT HAS EMETIC & ASTRINGENT ACTIONS.

A single instance has been reported in which use of a 3% /zinc phenolsufonate/ soln in eye compresses resulted in complete necrosis of both corneas of an infant.

Inhalation of dust may irritate nose and throat. Ingestion of large doses has emetic and astringent effects; can cause irritation or corrosion of the alimentary tract. Contact with eyes causes irritation. Contact with skin causes mild irritation. (USCG, 1999)

INHALATION: move to fresh air. INGESTION: if large amount has been swallowed, induce vomiting, followed by prompt and complete gastric lavage, cathartics, and demulcents. EYES or SKIN: flush with water. (USCG, 1999)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with sterile dressings after decontamination ... . /Sulfur and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Early intubation at the first sign of upper airway obstruction may be necessary. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam (Valium) ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid over load ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Sulfur and related compounds/

A single instance has been reported in which use of a 3% /zinc phenolsufonate/ soln in eye compresses resulted in complete necrosis of both corneas of an infant.|Subjects using 30 mM zinc phenolsulfonate as a mouthwash retained 12% of the zinc. Salivary zinc concn was increased using mouthwashes containing 17-35 mM zinc as zinc sulfonate, zinc phenolsulfonate, or zinc citrate. At 17 mM, the effect lasted 3-4 hr. Zinc retained in the mouth gave visible fluorescence after rinsing with 8-hydroxyquinoline, and this was particularly evident on the tongue, cheek mucosa, and dental plaque. The concn of zinc in plaque was increased 13 19 fold 1 hr after using 31 or 18 mM zinc phenolsulfonate. The effect of zinc on the metabolic activity of plaque may reduce the growth rate of plaque bacteria and so decrease plaque growth.

GRADE: TECHNICAL. /OCTAHYDRATE/|Grades of purity: purified /Octahydrate/|NF, granular, powder grades

Benzenesulfonic acid, 4-hydroxy-, zinc salt (2:1): ACTIVE|Zinc phenolsulfonate was used as ingredient of cosmetic preparations for reducing the redness of facial blemishes.|The effectiveness of metallic salt antiperspirants results from their ability to diffuse into the sweat duct and to form an obstructive hydroxide gel in situ. /Metallic salt antiperspirants/

Cosmetics -> Antimicrobial; Astringent; Deodorant