3-Bromo-1H-indazole

White solid

A. Bromine (1.5g, 9.4mmol) in 2M NaOH solution (lOmL) was added drop wise tosuspension of indazole (1.5g, 12.7mmol) in 2M NaOH solution (23mL) at ambient temperature. Stined the reaction mass for 3h at room temperature and added sodium bisulfate (0.05g) followed by the addition of 2N HC1. The solid precipitated was filtered out and washed with water, suction dried followed by in Rotavap under reduced pressure to afford the title compound (2g, 80percent). LCMS: mlz = 197.1 (M+H).3-Bromoindazole 4a was prepared using a procedure described by Boulton, B. E. and Coller, A. W (Aust. J Chem., 1974, 27, 2343-2346):

Molecular Weight:197.03
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:195.96361
Monoisotopic Mass:195.96361
Topological Polar Surface Area:28.7
Heavy Atom Count:10
Complexity:129
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes