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Isoginkgetin

Isoginkgetin structure

CAS No:
548-19-6
Formula:
C32H22O10
Chemical Name:
Isoginkgetin
Synonyms:
4H-1-Benzopyran-4-one,8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-;3′′′,8-Biflavone,5,5′′,7,7′′-tetrahydroxy-4′,4′′′-dimethoxy-;Isoginkgetin;8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;4′,4′′′-Dimethylamentoflavone
Categories:
Natural Products > Flavonoids

Description

Isoginkgetin is a MMP-9 inhibitor, also a Pre-mRNA Splicing Inhibitor with IC 50 of 30 uM.target : MMP-9 [1], Pre-mRNA Splicing [2]IC 50: 30 u M (Pre-mRNA Splicing)In vitro: Isoginkgetin inhibits HT1080 tumor cell invasion substantially. Isoginkgetin is also quite effective in inhibiting the activities of Akt and MMP-9 in MDA-MB-231 breast carcinomas and B16F10 melanoma. Isoginkgetin treatment result in marked decrease in invasion of these cells. isoginkgetin inhibit activities of both A

Solid

Isoginkgetin is a biflavonoid resulting from the formal oxidative dimerisation between position 8 of one molecule of 5,7-dihydroxy-4'-methoxyflavone and the 3' position of another. Found in the leaves of Ginkgo biloba, it is a potent inhibitor of matrix metalloproteinase 9 (MMP-9). It has a role as an EC 3.4.24.35 (gelatinase B) inhibitor, an antineoplastic agent and a plant metabolite. It is a biflavonoid and an aromatic ether. It derives from a 5,7-dihydroxy-4'-methoxyflavone.

Isoginkgetin Basic Attributes

Molecular Weight：

566.51

Exact Mass：

566.51

DSSTox ID：

DTXSID00203271

Characteristics

PSA：

152

XLogP3：

5.7

Appearance：

Solid

Density：

1.5±0.1 g/cm3

Melting Point：

355 °C

Boiling Point：

843.6ºC at 760mmHg

Flash Point：

280.2±27.8 °C

Refractive Index：

1.714

Water Solubility：

0.002419 mg/L @ 25 °C (est)

Drug Information

MeSH Entry Terms：

iso-ginkgetin

Computed Properties

Molecular Weight:566.5
XLogP3:5.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:5
Exact Mass:566.12129689
Monoisotopic Mass:566.12129689
Topological Polar Surface Area:152
Heavy Atom Count:42
Complexity:1080
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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ISOGINKGETIN

CAS No.: 548-19-6

Content: 99.00%

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Guide of Isoginkgetin

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
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Isoginkgetin

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