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N-Iodosuccinimide

N-Iodosuccinimide structure

CAS No:
516-12-1
Formula:
C4H4INO2
Chemical Name:
N-Iodosuccinimide
Synonyms:
2,5-Pyrrolidinedione,1-iodo-;Succinimide,N-iodo-;1-Iodo-2,5-pyrrolidinedione;N-Iodosuccinimide;NIS;Succiniodimide;856164-49-3
Categories:
Pharmaceutical Intermediates > Antibacterials

Description

white-yellow to brown crystalline powder

N-iodosuccinimide is a five-membered cyclic dicarboximide compound having an iodo substituent on the nitrogen atom. It is a dicarboximide and a pyrrolidinone. It derives from a succinimide.

N-Iodosuccinimide Basic Attributes

Molecular Weight：

224.98

Exact Mass：

224.98

BRN：

113917

EC Number：

208-221-6

UNII：

3COS3X3N4P

DSSTox ID：

DTXSID10199550

HScode：

29251995

Characteristics

PSA：

37.4

XLogP3：

-0.2

Appearance：

White-yellow to brown Crystalline Powder

Density：

2.3±0.1 g/cm3

Melting Point：

200-201 °C

Boiling Point：

249.6±23.0°C at 760 mmHg

Flash Point：

104.8±22.6 °C

Refractive Index：

1.653

Water Solubility：

Decomposes in water;soluble in dioxane, tetrahydrfuran and acetonitrile. Insoluble in ether and carbon tetrachloride.

Storage Conditions：

2-8°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

26-36-37/39

RTECS Number：

WN2817000

Marks：

Xn,Xi

Hazard note：

Harmful/Keep Cold/Moisture Sensitive

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (93.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 82 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

N-iodosuccinimide

N-Iodosuccinimide Use and Manufacturing

Methods of Manufacturing

Under light-shielding conditions, the succinimide is reacted with silver oxide to prepare N-succinimide silver. It is reacted with iodine in dry dioxane to produce N-iodosuccinimide.

Uses

Iodination of ketones and aldehydes.

Computed Properties

Molecular Weight:224.98
XLogP3:-0.2
Hydrogen Bond Acceptor Count:2
Exact Mass:224.92868
Monoisotopic Mass:224.92868
Topological Polar Surface Area:37.4
Heavy Atom Count:8
Complexity:129
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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