TERT-BUTYL N-(BENZYLOXY)CARBAMATE
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TERT-BUTYL N-(BENZYLOXY)CARBAMATE
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CAS No:
79722-21-7
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Formula:
C12H17NO3
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Chemical Name:
TERT-BUTYL N-(BENZYLOXY)CARBAMATE
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Synonyms:
LABOTEST-BB LT00452293;TERT-BUTYL N-(BENZYLOXY)CARBAMATE;N-(BENZYLOXY)CARBAMIC ACID TERT-BUTYL ESTER;TERT-BUTYL BENZYLOXYCARBAMATE;tert-Butyl N-(benzyloxy)carbamate ,98%;O-Benzylhydroxylamine, N-BOC protected, tert-Butyl (phenylmethoxy)carbamate;tert-Butyl (benzyloxy)carbamate 99%;N-Boc-Bn Tert-butyl n-(benzyloxy)carbamate
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CAS No:
TERT-BUTYL N-(BENZYLOXY)CARBAMATE Basic Attributes
223.27
223.120850
1533716-785-6
DTXSID30352943
2924299090
Safety Information
NONH for all modes of transport
3
36/37/38
26-36
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
TERT-BUTYL N-(BENZYLOXY)CARBAMATE Use and Manufacturing
Intermediate 153: tert-butyl benzyloxycarbamate To a solution of O-benzylhydroxylamine hydrochloride (225 g, 1.44 mol) in dichloromethane (300 mL) was added a solution of sodium bicarbonate (261 g, 3.11 mol, 300ml). After 1 hour the di-tert-butyl dicarbonate (375 g, 1.72 mol) was added at 0 °C. The resulting solution was stirred for 60 min at 0 °C in a water/ice bath and then the reaction was stirred for 16 h at room temperature. The reaction was then quenched by the addition of 300 mL of aqueous sodium bicarbonate. The aqueous phase was extracted with 3 x 500 mL of dichloromethane and the organic layers were combined and dried over anhydrous sodium sulfate and concentrated under vacuum. Flash chromatograph on silica gel (PE: EA=10: 1) afforded 220 g (69percent) of the title compound as a yellow oil. 1H MR (300MHz. COCh) δ: 1.43 (9H, s), 4.85 (2H, s), 7.19-7.21 (1H, brs), 7.30-7.40 (5H, m).O-Benzyl-hydroxylamine hydrochloride (300 mg, 1.89 mmol) was dissolved in DCM (5 mL). Nieri-butyl benzyloxycarbamate (150): /V-hydroxybenzyl-amine (1 equivalent, 1 .62 g) was dissolved in 30 ml of THF. BocEXAMPLE 4
Computed Properties
Molecular Weight:223.27
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:223.12084340
Monoisotopic Mass:223.12084340
Topological Polar Surface Area:47.6
Heavy Atom Count:16
Complexity:217
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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TERT-BUTYL N-(BENZYLOXY)CARBAMATE
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