Cysteamine hydrochloride
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Cysteamine hydrochloride
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CAS No:
156-57-0
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Formula:
C2H7NS.ClH
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Chemical Name:
Cysteamine hydrochloride
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Synonyms:
Ethanethiol,2-amino-,hydrochloride (1:1);Ethanethiol,2-amino-,hydrochloride;Cysteamine hydrochloride;2-Mercaptoethylamine hydrochloride;2-Aminoethanethiol hydrochloride;2-Mercaptoethylammonium chloride;Merkamin hydrochloride;Mercamine hydrochloride;Cysteaminium chloride;Cysteinamine hydrochloride;Cysteamine chlorohydrate;1-Amino-2-mercaptoethane hydrochloride;β-Mercaptoethylamine hydrochloride;2-Thioethylamine hydrochloride;CI 9148;2-Mercaptoethanamine hydrochloride;2-Aminoethanthiol hydrochloride;CT 2000;Lynovex;2-Mercaptoethanaminium chloride;2-Aminoethane-1-thiol hydrochloride;Cystadrops;CA 75A;116962-86-8;2022216-63-1
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CAS No:
Description
White Solid
A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.
Cysteamine hydrochloride Basic Attributes
113.61
113.007
205-858-1
IF1B771SVB
758692
DTXSID8045779
S01XA21
29309070
Characteristics
27
1.37720
white crystalline powder with a strong and disagreeable smell
0.75
70.2-70.7 °C
116.4°C at 760 mmHg
24.2ºC
1.6100 (estimate)
H2O: 1 m at 20 °C, clear, colorless
2-8ºC
16.7mmHg at 25°C
LD50 orally in Rabbit: 642 mg/kg
Safety Information
UN 3335
3
R22; R36/37/38
36/37/39-26-36
KJ0200000
Xn,Xi
Stable, but hygroscopic. Incompatible with strong oxidizing agents.
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (95.54%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 129 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Cystadrops is indicated for the treatment of corneal cystine crystal deposits in adults and children from 2 years of age with cystinosis.|Treatment of corneal cystine crystal deposits in cystinosis
Compounds and drugs that react with CYSTINE and convert it into a compound that can be more easily metabolized or intracellularly transported. Drugs in this class have been used to treat CYSTINOSIS. (See all compounds classified as Cystine Depleting Agents.)
2 Aminoethanethiol
Cysteamine hydrochloride Use and Manufacturing
In a reaction flask, S-2-(tert-butoxycarbonyl amino)ethyl-ethantionate (45.5 g, 0.17 mol), n-butanol (315.00 ml) and an aqueous solution of 37percent hydrochloric acid (34.29 g, 0.35 mol) were loaded, the temperature was raised to 75° C. and the reaction mixture was maintained under these conditions for about six hours.
Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.
Ethanethiol, 2-amino-, hydrochloride (1:1): ACTIVE
Human drugs -> Orphan -> Cystadrops -> EMA Drug Category|Ophthalmologicals -> Human pharmacotherapeutic group|Human drugs -> Rare disease (orphan)|Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Cosmetics -> Antioxidant; Reducing
Computed Properties
Molecular Weight:113.61
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:113.0065981
Monoisotopic Mass:113.0065981
Topological Polar Surface Area:27
Heavy Atom Count:5
Complexity:10
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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