Indole-3-butyric acid

203.23700

203.24

205-101-5

061SKE27JP

3130

DTXSID8032623

White to slightly yellow crystals|White to tan powder or crystalline solid

2942000000

53.09000

2.57520

Solid

1.252 g/cm3

124.5 °C

426.6ºC at 760 mmHg

211.8ºC

1.646

0.25 mg/mL at 20 °C

2-8ºC

4.9E-08mmHg at 25°C

Essentially odorless

Henry's Law constant: 1.3X10-11 atm cu m/mol@ 25 °C /Estimated/

pKa = 4.7 /Estimated/

Hydroxyl radical reaction rate constant: 2.0X10-10 cu cm/molecule-sec @ 25 °C /Estimated/

III

6.1

UN 2811 6.1/PG 3

3

R25; R36/37/38

S26-S28-S36/37/39-S38-S45

NL5250000

T

Stable. Incompatible with strong oxidizing agents. Light sensitive.

P261-P301 + P310-P305 + P351 + P338

H301-H315-H319-H335

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Indole-3-Butyric Acid, August 1992. The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of February 10, 2004: http://www.epa.gov/pesticides/reregistration/status.htm]

|Danger|H301 (98.72%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 156 companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P321, P330, P405, and P501

Non-flammable

LD50 Mouse oral 100 mg/kg|LD50 Mouse ip 100 mg/kg

Indolebutyric acid's production may result in its release to the environment through various waste streams; its use as a rooting hormone for plant cuttings and plant growth regulator(1,2) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 550(SRC), determined from a structure estimation method(2), indicates that indolebutyric acid is expected to have moderate to low mobility in soil(SRC). The estimated pKa of indolebutyric acid is 4.7 for the ionization of the carboxylic acid group(3), indicating that this compound will primarily exist in the dissociated form in the environment; anions generally do not adsorb to organic carbon and clay as strongly as their neutral counterparts(4). Volatilization of indolebutyric acid from moist soil surfaces is not expected to be an important fate process, since indolebutyric acid is expected to exist primarily in its dissociated form in the environment(SRC). Volatilization of the undissociated form of indolebutyric acid from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.3X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(7). Indolebutyric acid is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.8X10-6 mm Hg(SRC), determined from a fragment constant method(5). Indolebutyric acid was reported to degrade rapidly in soil(6).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 550(SRC), determined from a structure estimation method(2), indicates that indolebutyric acid is not expected to adsorb to suspended solids and sediment(SRC). This compound is expected to exist in the dissociated form in the environment, based on an estimated pKa of 4.7 for the ionization of the carboxylic acid group(3), and therefore volatilization from water surfaces is not expected to be an important fate process(SRC). Volatilization from water surfaces is not expected for the undissociated form of indolebutyric acid(9) based upon an estimated Henry's Law constant of 1.3X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(10). Indolebutyric acid is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(4). Indolebutyric acid was reported to be very stable in neutral, acidic, or alkaline media(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow of 2.30(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data for indolebutyric acid in water were not found; however, indolebutyric acid was reported to degrade rapidly in soil(11).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), indolebutyric acid, which has an estimated vapor pressure of 1.8X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase indolebutyric acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 hours(SRC), calculated from its rate constant of 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase indolebutyric acid may be removed from the air by wet and dry deposition(SRC). Indolebutyric acid may be susceptible to direct photolysis by sunlight(SRC), since it has an absorbance at 290 nm(4).

The rate constant for the vapor-phase reaction of indolebutyric acid with photochemically-produced hydroxyl radicals has been estimated as 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 2 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Indolebutyric acid is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). Indolebutyric acid was reported to be very stable in neutral, acidic, or alkaline media(3). Indolebutyric acid may be susceptible to direct photolysis by sunlight(SRC), since it has an absorbance at 290 nm(4).

An estimated BCF of 3 was calculated for indolebutyric acid(SRC), using a log Kow of 2.30(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for indolebutyric acid can be estimated to be 550(SRC). According to a classification scheme(2), this estimated Koc value suggests that indolebutyric acid is expected to have low mobility in soil. The estimated pKa of indolebutyric acid is 4.7 for the carboxylic acid group(3), indicating that this compound will primarily exist in the dissociated form in the environment; anions generally do not adsorb to organic carbon and clay as strongly as their neutral counterparts(4).

This compound is expected to exist in the dissociated form in the environment, based on an estimated pKa of 4.7(1), and therefore volatilization from water surfaces or moist soil surfaces is not expected to be an important fate process(SRC). Indolebutyric acid is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.8X10-6 mm Hg(SRC), determined from a fragment constant method(2).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 864 workers are potentially exposed to indolebutyric acid in the US(1). Occupational exposure to indolebutyric acid may occur through inhalation and dermal contact with this compound at workplaces where indolebutyric acid is produced or used(SRC). The general population may be exposed to indolebutyric acid via dermal contact with consumer products containing indolebutyric acid(SRC).

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

1H-indole-3-butanoic acid

Trade names: Hormodin, Seradix|Technical grade: 97.0%. Dust: 0.01%-4.5%; soluble concentrate/liquid: 0.0004%-1.03%; wettable powder/dust: 0.1%-0.8%.|Mixtures: Boll-Set (+gibberellic acid), Cytoplex HMS (+gibberellic acid+kinetin), Early Harvest (+cytokinins+gibberellic acid), Maxon II (+gibberellic acid), PGR-IV (+gibberellic acid), Super Lagniappe (+cytokinins+gibberellic acid).|Trade names: Synergol, Chryzoplus, Chryzopon, Chryzosan, Chryzotek, Chryzotop, Rhizopon AA.|Discontinued names: Rootone.

1H-Indole-3-butanoic acid: ACTIVE

Herbicides