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(Hydroxymethyl)urea

(Hydroxymethyl)urea structure

CAS No:
1000-82-4
Formula:
C2H6N2O2
Chemical Name:
(Hydroxymethyl)urea
Synonyms:
Urea,N-(hydroxymethyl)-;Urea,(hydroxymethyl)-;N-(Hydroxymethyl)urea;Methylolurea;N-Methylolurea;(Hydroxymethyl)urea;1-(Hydroxymethyl)urea;Mono(hydroxymethyl)urea;Monomethylolurea;NSC 13181
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Colorless crystals.Soluble inwater and methanol; insoluble in ether; capable ofpolymerization.ChEBI: A member of the class of ureas that is urea in which one of the amino hydrogens is replaced by a hydroxymethyl group.

Liquid

N-(hydroxymethyl)urea is a member of the class of ureas that is urea in which one of the amino hydrogens is replaced by a hydroxymethyl group.

(Hydroxymethyl)urea Basic Attributes

Molecular Weight：

90.082

Exact Mass：

90.08

EC Number：

213-674-8

UNII：

15BY095DMS

NSC Number：

13181

DSSTox ID：

DTXSID5027350

Color/Form：

PRISMS FROM ALCOHOL|COLORLESS CRYSTALS

HScode：

2924199090

Characteristics

PSA：

75.4

XLogP3：

-1.7

Appearance：

Liquid

Density：

1.311±0.06 g/cm3(Predicted)

Melting Point：

111 °C

Boiling Point：

110 °C

Flash Point：

97.5ºC

Water Solubility：

VERY SOL IN WATER; SOL IN METHANOL, ACETIC ACID; SOL IN HOT ALCOHOL; INSOL IN ETHER

Experimental Properties：

CAPABLE OF POLYMERIZATION TO SYNTHETIC RESIN

Safety Information

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Toxicity

Interactions：

PRETREATMENT OF MICE WITH AN ORAL 2 G/KG DOSE MONOMETHYLOLUREA REDUCED THE LD50 FOR FORMALDEHYDE FROM 330 TO 293 MG/KG.

Drug Information

Metabolism/Metabolites：

THE TICKS (BOOPHILUS MICROPLUS) WERE INJECTED WITH A DIMETHYL SULFOXIDE SOLN CONTAINING 1-(14)C-CARBARYL (0.5 TO 0.7 MCG) OR CARBONYL-(14)C-CARBARYL (0.2 MCG) IN 1- TO 3-MCL DOSES. TLC AUTORADIOGRAMS OF THE ACETONE EXTRACT TREATED WITH AMMONIA REVEALED THE PRESENCE OF N-HYDROXYMETHYLUREA.

MeSH Entry Terms：

N-(hydroxymethyl)urea

(Hydroxymethyl)urea Use and Manufacturing

Methods of Manufacturing

COMBINATION OF UREA AND FORMALDEHYDE, IN THE PRESENCE OF SALTS OR ALKALINE CATALYSTS.

Uses

Urea-formaldehyde resins, molding adhesives,treating textiles and wood.

Intermediates

Adhesives and sealants

Manufacturing Info：

Plastic material and resin manufacturing|Urea, N-(hydroxymethyl)-: ACTIVE|MICROBIAL BIOMASS (ACTIVATED SLUDGE OR OTHER CELLS) IS CHEM TREATED FOR USE AS REACTIVE FILLERS OR FLAMEPROOFING AGENTS IN SYNTHETIC MATERIALS. THUS, 1000 ACTIVATED SLUDGE (8.5% SOLIDS) WAS CONDENSED WITH 0.2 MOLAR FORMALDEHYDE & THEN MIXED WITH 90 G MONOMETHYLOLUREA & HELD AT 80 DEGREE C.

Computed Properties

Molecular Weight:90.08
XLogP3:-1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:90.042927438
Monoisotopic Mass:90.042927438
Topological Polar Surface Area:75.4
Heavy Atom Count:6
Complexity:53.5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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