Calcium bis(cyclohexylsulphamate)

221.33

396.07000

205-349-4

X12LMJ1WYL

TSCA listed

DTXSID9057892

Crystalline solid

155.22000

3.68120

white crystals

INDEX OF REFRACTION: 1.507 (ALPHA), 1.518 (BETA), 1.545 (GAMMA) /DIHYDRATE/

Soluble in water. Insoluble in most organic solvents.

Strong, sweet taste

NONHYGROSCOPIC, FREE-FLOWING; REACTS WITH TARTARIC ACID & TARTRATES, OXALATES, & SOME PHOSPHATES TO FORM INSOL CALCIUM SALTS|White crystals or powder; nearly odorless; very sweet taste. Freely soluble in water(solutions are neutral to litmus); Sweetening power approximately 30 times that of sucrose. /Dihydrate/

Xn

26-36

GV7100000

Xn

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Not permitted for use in foods and soft drinks, because of suspected carcinogenicity.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 54 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

MILK LEVELS OF CYCLAMATE IN LACTATING DOGS & RATS ADMIN CA CYCLAMATE WERE HIGHER THAN BLOOD LEVELS & ACCOUNTED FOR 0.001% OF DOSE/ML.

2. 2= SLIGHTLY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 5-15 G/KG, BETWEEN 1 PINT & 1 QUART FOR 70 KG PERSON (150 LB).

Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed) (See all compounds classified as Sweetening Agents.)

...PREVIOUSLY THOUGHT TO BE METABOLICALLY STABLE. WHEN GIVEN ORALLY TO GUINEA PIGS, RABBITS, RATS, & HUMANS ON CYCLAMATE-FREE DIET IT IS EXCRETED LARGELY UNCHANGED. /CYCLAMATE/|...CYCLOHEXYLAMINE FORMED IN INTESTINE IS ALMOST COMPLETELY ABSORBED & EXCRETED IN URINE, IN COMPARISON TO CYCLAMATE, WHICH IS ABSORBED TO AN EXTENT OF ONLY 20-40%. /CYCLAMATE/|...(14)C-CYCLAMATE, GIVEN IV TO WOMEN UNDERGOING THERAPEUTIC ABORTION, BY ABDOMINAL HYSTERECTOMY DURING EARLY PREGNANCY, CROSSED PLACENTA & DISPERSED IN FETAL TISSUES, PARTICULARLY IN LIVER, SPLEEN, PANCREAS, & KIDNEYS. ...MATERNAL BLOOD LEVELS...FELL RAPIDLY...INDICATING VERY RAPID ELIMINATION... /CYCLAMATE/|MAX DAILY EXCRETION OF CYCLOHEXYLAMINE...RANGED FROM 0.1 TO 0.9% OF DAILY CYCLAMATE INTAKE (5 G); URINARY OUTPUT OF CYCLOHEXYLAMINE WAS ERRATIC & CONTINUED FOR 3-4 DAYS AFTER ADMIN HAD CEASED. /CYCLAMATE/|For more Absorption, Distribution and Excretion (Complete) data for CALCIUM CYCLAMATE (6 total), please visit the HSDB record page.

/CALCIUM/ CYCLAMATE LABELLED WITH (35)S OR (14)C IS EXCRETED BY MAN & LABORATORY ANIMALS ALMOST ENTIRELY UNCHANGED, IN URINE & FECES, ALTHOUGH TRACES OF...CYCLOHEXYLAMINE (0.7% DOSE) HAVE BEEN FOUND IN URINE OF HUMANS & DOGS DOSED ORALLY...|...BIOTRANSFORMATION IN RATS...IS BROUGHT ABOUT BY GUT MICROFLORA. ...GUT MICROFLORA IN MAN & IN ANIMALS ACQUIRE CAPACITY TO METABOLIZE CYCLAMATE INTO CYCLOHEXYLAMINE, WHEN CYCLAMATE IS ADMIN CHRONICALLY. /CYCLAMATE/|GUT MICRO-ORGANISMS, WHICH BECOME CYCLAMATE "CONVERTERS" ARE CLOSTRIDIA IN RATS, ENTEROBACTERIA IN RABBITS, & ENTEROCOCCI IN MAN. /CYCLAMATE/|...2 GROUPS OF WEANLING RATS WERE FED FOR 8 MO...WITH CHOW DIET OR...DIET CONTAINING 0.1% CA CYCLAMATE...THEN A SINGLE DOSE OF (14)C-CYCLAMATE BY STOMACH TUBE. ...7/11 CYCLAMATE-FED RATS CONVERTED CYCLAMATE INTO CYCLOHEXYLAMINE, TO...12-25% OF TOTAL (14)C IN URINE. 2 OF THE URINES CONTAINED TRACES OF DICYCLOHEXYLAMINE...|WHEN GUINEA PIGS, RABBITS, RATS, & HUMANS WERE PLACED ON A DIET CONTAINING CALCIUM CYCLAMATE THEY DEVELOPED THE ABILITY TO CONVERT ORALLY ADMIN CYCLAMATE INTO CYCLOHEXYLAMINE & THE METABOLITES OF THE LATTER.

...IV DOSE OF 14(C)-CYCLAMATE TO PREGNANT RAT...T/2 OF CYCLAMATE WAS ABOUT 7 HR. /CYCLAMATE/

A WOMAN PATIENTS WHO TOOK LARGE AMT OF CA CYCLAMATE HAD A PHOTOSENSITIVE DERMATITIS & RENAL TUBULAR ACIDOSIS ASSOCIATED WITH HYPOPHOSPHATEMIA.|3 PATIENTS DESCRIBED DEVELOPED VESICAL CARCINOMA OF BLADDER AFTER PROLONGED PERIOD OF INGESTION OF UNUSUALLY HIGH AMT OF CYCLAMATE SWEETNER, SEVERITY APPEARED IN PROPORTION TO DOSE INGESTED.|An epidemiologic study designed to elucidate the possible roles of the artificial sweeteners saccharin and cyclamate in human urinary bladder cancer was completed. The previous intake of each of these substances among 519 patients with histopathologically confirmed bladder cancer and an equal number of matching controls in metropolitan Baltimore (USA) did not differ significantly in frequency, quantity or duration. These normal findings persisted after simultaneous adjustment for the effects of smoking, occupation, age, diabetes mellitus and a number of other potentially confounding factors. They are substantiated by the failure of the relative risk of bladder cancer to increase with increasing exposure to artificial sweeteners. Neither saccharin nor cyclamate is likely to be carcinogenic in man, at least at the moderate dietary ingestion levels reported by the patient sample.|IN VIVO, CYCLAMATE IS CONVERTED INTO CYCLOHEXYLAMINE WHICH PER SE OR AFTER BIOTRANSFORMATION MAY PROVIDE AN ULTIMATE CARCINOGEN. /CYCLAMATE/|For more Human Toxicity Excerpts (Complete) data for CALCIUM CYCLAMATE (6 total), please visit the HSDB record page.

Calcium Cyclamate

SALE OF BEVERAGES CONTAINING CYCLAMATES WAS PROHIBITED BY US FOOD & DRUG ADMINISTRATION ON JANUARY 1, 1970, AND SALE OF OTHER FOOD PRODUCTS CONTAINING CYCLAMATES WAS PROHIBITED ON SEPTEMBER 1, 1970 (1970)

...SOLD UNDER TRADEMARK, SUCH AS SUCARYL CALCIUM OF ABBOTT LABORATORIES & CYLAN CALCIUM CYCLAMATE OF DUPONT.|CYCLAN; CYLAN; DIETIL...IN THE US, CALCIUM CYCLAMATE WAS AVAILABLE COMMERCIALLY IN 1970 AS A US NATIONAL FORMULARY (NF) GRADE CRYSTALLINE POWDER CONTAINING 98-101% ACTIVE INGREDIENT ON AN ANHYDROUS BASIS, 6-9% WATER, A MAXIMUM OF 30 MG/KG SELENIUM, 25 MG/KG CYCLOHEXYLAMINE, 10 MG/KG HEAVY METALS & 3 MG/KG ARSENIC. ...AQ SOLN CONTAINING ABOUT 6% CALCIUM CYCLAMATE COMBINED WITH ABOUT 0.6% CALCIUM SACCHARIN, &...TABLETS CONTAINING ABOUT 50 MG CALCIUM CYCLAMATE COMBINED WITH ABOUT 5 MG CALCIUM SACCHARIN.|Grades: NF, FCC /Dihydrate/|PURITY: 98% MINIMUM /DIHYDRATE/

Sulfamic acid, N-cyclohexyl-, calcium salt (2:1): INACTIVE|CYCLAMATES ARE CURRENTLY BANNED AS FOOD ADDITIVES IN MANY COUNTRIES (USA, UK, CANADA, SWEDEN, FINLAND, ETC).|NON-CALORIC SWEETENING AGENT USED ALONE OR IN COMBINATION WITH SACCHARIN ... TEN PARTS CYCLAMATE TO ONE PART SACCHARIN IS A COMMON COMBINATION ... SOME NON-NUTRITIVE SOFT DRINKS CONTAIN 0.125% CYCLAMATE. /CYCLAMATE SODIUM OR CALCIUM/|Cyclamate sweeteners, once available in the United States but now banned ... are still available in Canada.

SPECTROPHOTOMETRIC DETERMINATION IN CANNED FRUITS.|IN LIQUID FOODS, DETERMINATION BY UV SPECTROPHOTOMETRY AS LOW AS 0.001%.|GAS CHROMATOGRAPHIC DETERMINATION OF CYCLIC AMINES, KETONES & ALCOHOLS, POSSIBLE METABOLITES OF SWEET SULFAMATES.|GAS CHROMATOGRAPHIC DETERMINATION OF MICRO-AMT OF CYCLAMATES.

Food Additives -> SWEETENER; -> JECFA Functional Classes|Cosmetics -> Masking

Food Additives -> SWEETENER;