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N-Acetyl-L-leucine

N-Acetyl-L-leucine structure

CAS No:
1188-21-2
Formula:
C8H15NO3
Chemical Name:
N-Acetyl-L-leucine
Synonyms:
L-Leucine,N-acetyl-;Leucine,N-acetyl-,L-;N-Acetyl-L-leucine;N-Acetylleucine;Acetyl-L-leucine;N-Acetyl-L-(-)-leucine;Acetylleucine;NSC 206316;(S)-2-Acetamido-4-methylpentanoic acid;(-)-N-Acetyl-L-leucine;(2S)-2-Acetamido-4-methylpentanoic acid;24160-46-1;90243-88-2
Categories:
Pharmaceutical Intermediates > Immunological Agents

Description

Solid

N-acetyl-L-leucine is the N-acetyl derivative of L-leucine. It has a role as a metabolite. It is a N-acetyl-L-amino acid and a L-leucine derivative. It is a conjugate acid of a N-acetyl-L-leucinate. It is an enantiomer of a N-acetyl-D-leucine.

N-Acetyl-L-leucine Basic Attributes

Molecular Weight：

173.21000

Exact Mass：

173.21

EC Number：

214-706-3

UNII：

E915HL7K2O

NSC Number：

758152

DSSTox ID：

DTXSID6045870

HScode：

2924199090

Characteristics

PSA：

66.40000

XLogP3：

0.5

Appearance：

Solid

Density：

1.069g/cm3

Melting Point：

189-190 °C

Boiling Point：

369.7ºC at 760mmHg

Flash Point：

177.4ºC

Refractive Index：

-22 ° (C=5, EtOH)

Water Solubility：

H2O: 0.81 g/100 mL (20 ºC)

Storage Conditions：

-20ºC

Vapor Pressure：

1.77E-06mmHg at 25°C

Collision Cross Section：

149.9 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|140.5 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|140.7 Å² [M-H]-

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S24/25

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 69 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

acetyl-DL-leucine

N-Acetyl-L-leucine Use and Manufacturing

Uses

Acetylleucine is a drug used in the treatment of vertigo.

Manufacturing Info：

L-Leucine, N-acetyl-: INACTIVE

Computed Properties

Molecular Weight:173.21
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:173.10519334
Monoisotopic Mass:173.10519334
Topological Polar Surface Area:66.4
Heavy Atom Count:12
Complexity:177
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Sodium hydroxide

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