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Tolpentamide

Tolpentamide structure

CAS No:
1027-87-8
Formula:
C13H18N2O3S
Chemical Name:
Tolpentamide
Synonyms:
Tolpentamide;1-CYCLOPENTYL-3-(P-TOSYL)UREA;1-Cyclopentyl-3-p-tolylsulfonylurea;N-[(Cyclopentylamino)carbonyl]-4-methylbenzenesulfonamide
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Tolpentamide is a first-generation cyclopentyl-containing sulfonylurea with hypoglycemic activity. Tolpentamide was never marketed.

Tolpentamide Basic Attributes

Molecular Weight：

282.358

Exact Mass：

282.10400

UNII：

4G278XM8KC

DSSTox ID：

DTXSID6046395

NCI Thesaurus Code：

C73143

HScode：

2935009090

Characteristics

PSA：

83.6

XLogP3：

3.60160

Density：

1.2378 (rough estimate)

Refractive Index：

1.6360 (estimate)

Safety Information

Precautionary statement(s)：

P264, P280, P305+P351+P338, P33, P313

Hazard Statements：

H319

GHS Classification：

|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Computed Properties

Molecular Weight:282.36
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:282.10381361
Monoisotopic Mass:282.10381361
Topological Polar Surface Area:83.6
Heavy Atom Count:19
Complexity:402
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes