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4-(Dimethylamino)pyridine

4-(Dimethylamino)pyridine structure

CAS No:
1122-58-3
Formula:
C7H10N2
Chemical Name:
4-(Dimethylamino)pyridine
Synonyms:
4-Pyridinamine,N,N-dimethyl-;Pyridine,4-(dimethylamino)-;N,N-Dimethyl-4-pyridinamine;4-(Dimethylamino)pyridine;N,N-Dimethyl-4-aminopyridine;γ-(Dimethylamino)pyridine;p-Dimethylaminopyridine;DMAP;4-DMAP;DMAP (catalyst);4-(N,N-Dimethylamino)pyridine;N,N-Dimethyl-4-pyridylamine;4DMAPy;2011746-50-0
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

4-Dialkylaminopyridines were soon found to have general applicability for catalysis of a wide variety of reactions. 4-dimethylaminopyridine’s (DMAP) wide applicability has been frequently reviewed since the first review appeared in 1978. [3] The accelerating pace of reported applications for DMAP and the availability of DMAP in commercial quantities, at modest prices, have continued to stimulate great interest in its use as a catalyst in the fields of organic, polymer, analytical and biochemist

OtherSolid; PelletsLargeCrystals

4-(Dimethylamino)pyridine Basic Attributes

Molecular Weight：

122.16800

Exact Mass：

122.17

EC Number：

214-353-5

UNII：

PFP1R6P0S8

DSSTox ID：

DTXSID0044369

HScode：

2933399090

Characteristics

PSA：

16.13000

XLogP3：

1.3

Appearance：

OtherSolid; PelletsLargeCrystals

Density：

1.012 g/cm3

Melting Point：

112 °C

Boiling Point：

162 °C

Flash Point：

110ºC

Refractive Index：

n20/D 1.431

Water Solubility：

76 g/L (25 ºC)

Storage Conditions：

Store in dark

Vapor Pressure：

0.431mmHg at 25°C

Toxicity：

LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg

Safety Information

Packing level：

Hazard category：

Transport codes：

UN 1760/2811

wgk germany：

hazard class code：

R24/25; R34

safety instructions：

S26-S28-S36/37/39-S45

RTECS Number：

US8400000

Marks：

Stability/Shelf Life：

Stable. Incompatible with acids, oxidizing agents.

Precautionary statement(s)：

Missing Phrase - N15.00950417-P262-P280-P302 + P352 + P310-P305 + P351 + P338-P361 + P364

Hazard Statements：

H301-H310-H315-H319-H335

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P262, P264, P270, P271, P273, P280, P301+P310, P301+P330+P331, P302+P350, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P310, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 624 companies from 44 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

4-dimethylaminopyridine

4-(Dimethylamino)pyridine Use and Manufacturing

Uses

1. A highly efficient catalyst for acylation reactions.
2. 4-Dimethylaminopyridine is a versatile hypernucleophilic acylation catalyst, it is used to improve the yield, reduce the reaction time, improving relaxation process conditions. Widely used in perfumes, dyes, pigments, pesticides, pharmaceuticals and polymer compounds and other fields. Also used as a catalyst for the synthesis of polyurethane, a curing agent and a blowing catalyst.
3. DMAP is a useful highly basic nucleophilic catalyst for a variety of reactions such as esterifications with anhydrides, the Baylis-Hillman reaction, hydrosilylations, tritylation, the Steglich rearrangement.
4. A highly fluorescent adenosine analogue, which in a dimethoxytrityl, phosphoramidite protected form, can be site-specifically inserted into oligonucleotides through a 3?5?phosphodiester linkage using an automated DNA synthesizer

Intermediates

Intermediate

Manufacturing Info：

Pesticide, fertilizer, and other agricultural chemical manufacturing|4-Pyridinamine, N,N-dimethyl-: ACTIVE

Computed Properties

Molecular Weight:122.17
XLogP3:1.3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:122.084398327
Monoisotopic Mass:122.084398327
Topological Polar Surface Area:16.1
Heavy Atom Count:9
Complexity:75
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Pyridine

Acetylacetone

4-Methoxypyridine

Methanol

Dimethylformamide

Downstream Products

Formaldehyde

Phthalic anhydride

Recommended Suppliers of 4-(Dimethylamino)pyridine

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CN
3 YRS

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RF.4-(Dimethylamino)pyridine(1122-58-3)

CAS No.: 1122-58-3

Inquiry
SHANDONG LOOK CHEMICAL CO.,LTD Contact Supplier

CN
5 YRS

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Dimethylaminopyridine 99%

CAS No.: 1122-58-3

Grade: Dimethylaminopyridine

Content: 99%

Inquiry
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CN
2 YRS

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Trader Supplier of Ortho-xylene,1-Butylene,Ammonium hydrogen fluoride,Bitumen

Pharmaceutical grade 99.9% 4-Dimethylaminopyridine

CAS No.: 1122-58-3

Grade: Pharmaceutical Grade

Content: 99.9%

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CN
11 YRS

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Manufactory Supplier

4-Dimethylaminopyridine 99.9%

CAS No.: 1122-58-3

Grade: Industrial Grade

Content: 99.9%

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CN
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DMAP/4-Dimethylaminopyridine 99% see COA kanbei

CAS No.: 1122-58-3

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Latest News on 4-(Dimethylamino)pyridine

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Guide of 4-(Dimethylamino)pyridine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Downstream Products
Recommended Suppliers
Latest News
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4-(Dimethylamino)pyridine

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