2,4,5-Triamino-6-chloropyrimidine

2, 5-diamino-4, 6-dichloropyrimidine (1 equivalent) was suspended in NH4OH (18 mL/mmol), heated in a sealed tube to 135 °C for 24 h, concentrated in vacuo then purified by chromatography on silica gel (eluent dichloromethane / methanol / NH4OH) to afford pure compound 69 (93percent). Intermediate 17.6-Chloropyrimidine-2, 4, 5-triamine To a suspension of (E)-6-Chloro-5-((4-chlorophenyl)diazenyl)pyrimidine-2, 4- diamine (2.2 g, 7 mmol) in THF (70 mL) was added acetic acid (10 mL) followed by Zn dust (3.3 g, 50 mmol) at 0 °C. The reaction was stirred for 30 minutes then filtered through a pad of Celite. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel chromatography (0–30percent 90:9:1 mixture of CH

Molecular Weight:159.58
XLogP3:-0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Exact Mass:159.0311729
Monoisotopic Mass:159.0311729
Topological Polar Surface Area:104
Heavy Atom Count:10
Complexity:120
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes