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Gestonorone caproate

Gestonorone caproate structure

CAS No:
1253-28-7
Formula:
C26H38O4
Chemical Name:
Gestonorone caproate
Synonyms:
19-Norpregn-4-ene-3,20-dione,17-[(1-oxohexyl)oxy]-;19-Norpregn-4-ene-3,20-dione,17-hydroxy-,hexanoate;Hexanoic acid,ester with 17-hydroxy-19-norpregn-4-ene-3,20-dione;17-[(1-Oxohexyl)oxy]-19-norpregn-4-ene-3,20-dione;Gestonorone caproate;17-Hydroxy-19-norpregn-4-ene-3,20-dione hexanoate;19-Norpregn-4-ene-3,20-dione 17-caproate;Gestonorone capronate;Depostat;Gestronol hexanoate;17α-Hydroxy-19-norprogesterone capronate;17α-Hydroxy-19-norprogesterone caproate;SH 80582;SH 582;17β-Acetyl-17-hydroxyestr-4-ene-3-one hexanoate;Gestronol caproate;19-Nor-17α-caproyloxy-4-pregnene-3,20-dione;Primostat;ZK 5623;NSC 84054;Gestonorone hexanoate
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

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Description

Gestonorone Capronate is a progestin for the treatment of benign prostatic hypertrophy and endometrial cancer.

Gestonorone caproate Basic Attributes

Molecular Weight：

414.58

Exact Mass：

414.58

EC Number：

215-010-2

NSC Number：

84054

Characteristics

PSA：

60.44000

XLogP3：

5.57950

Density：

1.11

Melting Point：

123.5 °C

Boiling Point：

535.4ºC at 760mmHg

Flash Point：

228.4ºC

Refractive Index：

1.534

Vapor Pressure：

1.54E-11mmHg at 25°C

Specific rotation：

D +13° (chloroform)

Safety Information

Precautionary statement(s)：

P201, P202, P260, P263, P264, P270, P281, P308+P313, P405, P501

Hazard Statements：

H351

GHS Classification：

|Danger|H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]|P201, P202, P260, P263, P264, P270, P281, P308+P313, P405, and P501|Aggregated GHS information provided by 24 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gestonorone caproate Use and Manufacturing

Gestonorone Capronate, is a pro-drug of Gestonorone, which is a steroidal progestin. It has been shown to have accelerated body weight gain and caused the atrophy of the prostate, uterus, and seminal vesicles in rats. It is also an inhibitor of the reductive pathway of Testosterone (T155000) metabolism.

Computed Properties

Molecular Weight:414.6
XLogP3:5.1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:414.27700969
Monoisotopic Mass:414.27700969
Topological Polar Surface Area:60.4
Heavy Atom Count:30
Complexity:752
Undefined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes