2,4-Dichlorofluorobenzene
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2,4-Dichlorofluorobenzene
structure -
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CAS No:
1435-48-9
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Formula:
C6H3Cl2F
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Chemical Name:
2,4-Dichlorofluorobenzene
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Synonyms:
Benzene,2,4-dichloro-1-fluoro-;2,4-Dichloro-1-fluorobenzene;2,4-Dichlorofluorobenzene;1-Fluoro-2,4-dichlorobenzene;1,3-Dichloro-4-fluorobenzene;2,6-Dichloro-3-fluorophenyl;1,3-Bischloro-4-fluorobenzene;2,4-Dichloro-1-fluorbenzene
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CAS No:
Characteristics
0
3.4
clear, colorless clear liquid
1.4092 g/cm3 @ Temp: 20 °C
-13.8--13.2 °C
172-174 °C
98 °F
n 20/D 1.525(lit.)
insoluble
Flammables area
1.35mmHg at 25°C
Safety Information
III
9
UN 1993 3/PG 3
3
22-38-48/20/22-51/53-10-36/37/38
36/37-61-16-36-26
Xn,N,Xi
Irritant
P260, P264, P270, P273, P280, P301+P312, P302+P352, P314, P321, P330, P332+P313, P362, P391, P501
H302
|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P312, P302+P352, P314, P321, P330, P332+P313, P362, P391, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|Aggregated GHS information provided by 33 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H226 (90.7%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P264, P270, P273, P280, P301+P312, P302+P352, P303+P361+P353, P314, P321, P330, P332+P313, P362, P370+P378, P391, P403+P235, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501
2,4-Dichlorofluorobenzene Use and Manufacturing
(1) 3-Chloro-4-fluoroaniline diazotization method The process is mature, the product quality is good, but the price is relatively high, so it is limited to laboratory synthesis. (2) 2, 4-Dinitrofluorobenzene chlorination method This method is the main production method of 2, 4-dichlorofluorobenzene, with the lowest cost and the best economic benefits. (3) 3-chloro-4-fluoronitrobenzene chlorination method The conversion rate of 3-chloro-4-fluoronitrobenzene in this method is 95%, and the selectivity to 2, 4-dichlorofluorobenzene is 90% . If nitroxyl chloride is used instead of chlorine in the reaction, the selectivity may increase to 94.3%. (4) 5-chloro-2-fluoronitrobenzene chlorination method The product yield of this method is 74.5%.
Used as an intermediate for pesticides and pharmaceuticals, as an intermediate for a new fluoroquinolone antibacterial drug ciprofloxacin
Computed Properties
Molecular Weight:164.99
XLogP3:3.4
Hydrogen Bond Acceptor Count:1
Exact Mass:163.9595836
Monoisotopic Mass:163.9595836
Heavy Atom Count:9
Complexity:97.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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Business licensed Certified factoryManufactory Supplier of Flavors & Fragrances,Catalyst & Auxiliary,Intermediates,Dyes & Pigments,Inorganic Chemistry,petro chemicals,Surfactant,Food Additives,Water Treatment ChemicalsInquiryCAS No.: 1435-48-9Grade: Industrial GradeContent: 99%
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