 Home > Encyclopedia > Hydroquinidine

Hydroquinidine

Hydroquinidine structure

CAS No:
1435-55-8
Formula:
C20H26N2O2
Chemical Name:
Hydroquinidine
Synonyms:
Cinchonan-9-ol,10,11-dihydro-6′-methoxy-,(9S)-;Hydroquinidine;(9S)-10,11-Dihydro-6′-methoxycinchonan-9-ol;Dihydroquinidine;Hydroconquinine;10,11-Dihydroquinidine;(+)-Hydroquinidine;1415-00-5;900786-91-6;904813-09-8;1089762-75-3;1195456-48-4;2176466-42-3
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Solid

Hydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).

Hydroquinidine Basic Attributes

Molecular Weight：

326.43

Exact Mass：

326.43

EC Number：

215-862-5

UNII：

8P68XPY4HG

ATC Code：

C - Cardiovascular system

HScode：

29339900

Characteristics

PSA：

45.6

Density：

1.1117 (rough estimate)

Melting Point：

168.5 °C

Boiling Point：

464.47°C (rough estimate)

Flash Point：

255.2±24.6 °C

Refractive Index：

1.6800 (estimate)

Water Solubility：

chloroform: 0.1 g/mL, clear

Specific rotation：

226 º (C=2 IN ETOH)

Collision Cross Section：

176.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

wgk germany：

hazard class code：

20/21/22

safety instructions：

36/37-36

RTECS Number：

MX3016000

Marks：

Precautionary statement(s)：

P280

Hazard Statements：

H302 + H312 + H332

GHS Classification：

|Warning|H302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

dihydroquinidine

Hydroquinidine Use and Manufacturing

antiarrhythmic, antimalarial

Computed Properties

Molecular Weight:326.4
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:326.199428076
Monoisotopic Mass:326.199428076
Topological Polar Surface Area:45.6
Heavy Atom Count:24
Complexity:432
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Hydroquinidine

Cuicheng Biomedical Technology Contact Supplier

CN
1 YR

Business licensed Certified factory

Manufactory Supplier of Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5,Ginsenoside Rg5,Ginsenoside Rh2,Protopanaxatriol,Epmedin C,Icariin,Icaritin,Baohuoside I,Total Ginsenosides,Total Ginsenosides from Ginseng Stems And Leaves,Oridonin,Oleuropein,Curcumin,(20)-Ginsenoside Rg3,(20)-Protopanaxadiol

Hydroquinidine

Unit Price: $4300-4500 /MT FOB

CAS No.: 1435-55-8

Grade: Industrial Grade

Content: 98%

Inquiry