N-1-Naphthylethylenediamine dihydrochloride

259.17

258.069061

3707471

215-981-2

H734599KJL

DTXSID8020917

LONG HEXAGONAL PRISMS

29215990

38

4.58770

White to beige or pink Powder

188-190 °C

370.7ºC at 760 mmHg

209.7ºC

H2O: soluble

Store at RT.

Negligible (NTP, 1992)

Peritoneal-mouse LD50: 150 mg/kg

Heat releases toxic hydrogen chloride and nitrogen oxide gas

This chemical is hygroscopic. Slightly soluble in water.

Amines, Phosphines, and Pyridines

N-(1-NAPHTHYL)ETHYLENEDIAMINE DIHYDROCHLORIDE may decompose on exposure to light. This chemical is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. (NTP, 1992)

I; II; III

6.1

NONH for all modes of transport

3

36/37/38-22-39/23/24/25-20/21/22

36/37-45-37/39-26-36

KV5330000

T,Xn,Xi

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Stable under normal temperatures and pressures.

P305 + P351 + P338

H315-H319

DHEW/NCI; Bioassay of N-(1-naphthyl)ethylenediamine dihydrochloride for Possible Carcinogenicity (1979) Technical Rpt Series No. 168 DHEW Pub No. (NIH) 79-1724

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 56 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. You should then dampen the solid spill material with 60-70% methanol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with methanol to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash contaminated surfaces with 60-70% methanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

highly toxic

A bioassay for the possible carcinogenicity of N-(1-naphthyl)ethylenediamine dihydrochloride was conducted using Fischer 344 rats and B6C3F1 mice. N-(1-Naphthyl)ethylenediamine dihydrochloride was administered in the feed, at either of two concn, to groups of 50 male and 50 female animals of each species. Twenty-five rats of each sex and 50 mice of each sex were placed on test as controls. The high and low dietary concentrations of N-(1-naphthyl)ethylenediamine dihydrochloride admin to rats and male mice were 0.1 and 0.05 %, respectively. The high and low time-weighted avg concn admin to female mice were, respectively, 0.3 and 0.2%. The cmpd was admin in the diet for 104 wk, followed by an observation period of 4 wk for high dose rats, 3 wk for low dose rats, low dose female mice, and high dose female mice, and 1 wk for high dose male mice. ... In all groups, except for high dose females, adequate numbers of animals survived sufficiently long to be at risk from late-developing tumors. ... Under the conditions of this bioassay, dietary admin of N-(l-naphthyl)ethylenediamine dihydrochloride was not carcinogenic in Fischer 344 rats or B6C3Fl mice. ... Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative.

SYMPTOMS: Symptoms of exposure to this chemical include irritation of the mucous membranes and upper respiratory tract. ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion or skin absorption. It is an irritant of the mucous membranes and upper respiratory tract. When heated to decomposition it emits very toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides and hydrogen chloride gas. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

N-(1-naphthyl)ethylenediamine

ESSENTIALLY 100% AS CHEMICAL REAGENT

1,2-Ethanediamine, N1-1-naphthalenyl-, hydrochloride (1:2): ACTIVE