Tropisetron hydrochloride
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Tropisetron hydrochloride
structure -
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CAS No:
105826-92-4
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Formula:
C17H20N2O2.ClH
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Chemical Name:
Tropisetron hydrochloride
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Synonyms:
1H-Indole-3-carboxylic acid,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,hydrochloride (1:1);1H-Indole-3-carboxylic acid,8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,monohydrochloride,endo-;1H-Indole-3-carboxylic acid,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,monohydrochloride;SDZ-ICS 930;Novaban;Tropisetron hydrochloride
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CAS No:
Description
White to Off-White Crystalline SolidChEBI: A hydrochloride obtained by combining equimolar amounts of tropisetron and hydrogen chloride.
Tropisetron hydrochloride is a hydrochloride obtained by combining equimolar amounts of tropisetron and hydrogen chloride. It has a role as an anti-inflammatory agent, an antiemetic, an apoptosis inhibitor, an immunomodulator, a neuroprotective agent, a nicotinic acetylcholine receptor agonist, a serotonergic antagonist and a trypanocidal drug. It contains a tropisetron(1+).|Tropisetron Hydrochloride is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinauseant and antiemetic activities. Tropisetron competitively binds to and blocks the action of serotonin at 5HT3 receptors peripherally on vagus nerve terminals located in the gastrointestinal (GI) tract as well as centrally in the chemoreceptor trigger zone (CTZ) of the area postrema of the central nervous system (CNS). This results in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.|An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting.
Tropisetron hydrochloride Basic Attributes
320.81
320.129150
1312995-182-4
A19338Q2YO
C95284
29399990
Characteristics
45.3
2.83000
283-285 °C
448.5ºC at 760 mmHg
225ºC
soluble in water;H2O: >10mg/mL
2-8°C
3.09E-08mmHg at 25°C
Safety Information
III
6.1
2811
3
NL6012520
|Danger|H301 (75%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P273, P301+P310, P301+P312, P314, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)|Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS. (See all compounds classified as Serotonin 5-HT3 Receptor Antagonists.)
(3 alpha-tropanyl)-1H-indole-3-carboxylic acid ester
Tropisetron hydrochloride Use and Manufacturing
Specific serotonin (5-HT3) receptor antagonist. Antiemetic.
Computed Properties
Molecular Weight:320.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:320.1291556
Monoisotopic Mass:320.1291556
Topological Polar Surface Area:45.3
Heavy Atom Count:22
Complexity:400
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It is a potent and highly selective competitive antagonist of 5-hydroxytryptamine 3 (5-HT3) receptors in peripheral neurons and the central nervous system. It inhibits the vomiting reflex mainly by selectively blocking the presynaptic 5-HT3 receptors of peripheral neurons. In addition, its antiemetic effect may also be related to its inhibition of the stimulation of the vagus nerve in the rear region by directly blocking the central 5-HT3 receptors.
Registered Holders
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Zein BIOTECHNOLOGY Co., Ltd.
Active
China
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Minsheng Group Shaoxing Pharmaceutical Co., Ltd.
Active
China
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ZHONGFU Pharmaceutical Co., Ltd.
Active
China
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