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Piperaquine phosphate

Piperaquine phosphate structure

CAS No:
85547-56-4
Formula:
C29H32Cl2N6.xH3O4P
Chemical Name:
Piperaquine phosphate
Synonyms:
Quinoline,4,4′-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-,phosphate (1:1);Quinoline,4,4′-(1,3-propanediyldi-4,1-piperazinediyl)bis[7-chloro-,phosphate;Piperaquine phosphate
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

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Piperaquine phosphate Basic Attributes

Molecular Weight：

633.51

Exact Mass：

632.183472

EC Number：

1312995-182-4

UNII：

5A17BAT3GK

ATC Code：

P01BF05

HScode：

2942000000

Characteristics

PSA：

117

XLogP3：

4.50130

Boiling Point：

721.1ºC at 760mmHg

Flash Point：

389.9ºC

Drug Information

Drug Indication：

Eurartesim is indicated for the treatment of uncomplicated Plasmodium falciparum malaria in adults, children and infants 6 months and over and weighing 5 kg or more.Consideration should be given to official guidance on the appropriate use of antimalarial agents.

Piperaquine phosphate Use and Manufacturing

Use Classification：

Human drugs -> Eurartesim -> EMA Drug Category|Antiprotozoals -> Human pharmacotherapeutic group

Computed Properties

Molecular Weight:633.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:6
Exact Mass:632.1834460
Monoisotopic Mass:632.1834460
Topological Polar Surface Area:117
Heavy Atom Count:42
Complexity:704
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

The antimalarial effect is similar to that of chloroquine. After oral absorption, it is stored in the liver and then slowly released into the blood. It has a long-lasting effect and can be used for the prevention and treatment of malaria symptoms.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Piperaquine phosphate
Manufacturer	Zhuhai Rundu Pharmaceutical Co., Ltd.

Compound Dihydroartemisinin Tablets
Ingredients	Main ingredients: This product contains dihydroartemisinin, piperaquine phosphate and trimethoprim.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Dihydroartemisinin 32mg, piperaquine phosphate 320mg, trimethoprim 90mg
Manufacturer	Chongqing Tonghe Pharmaceutical Co., Ltd.

Piperaquine Phosphate Tablets
Ingredients	This product mainly contains piperaquine phosphate, and its chemical name is: 1,3-bis[4-(7-chloro-quinoline-4-yl)piperazine-1-yl]propane tetraphosphate tetrahydrate.
Indication	Not yet clear.
Specifications	0.25g
Manufacturer	Hainan Quanxing Pharmaceutical Co., Ltd.

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Registered Holders

Chongqing Kangle Pharmaceutical Co., Ltd.

China
Active
Chongqing Southwest NO.2 Pharmaceutical FACTORY Co., Ltd.

China
Active
Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd.

China
Active

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