 Home > Encyclopedia > Acifluorfen

Acifluorfen

Acifluorfen structure

CAS No:
50594-66-6
Formula:
C14H7ClF3NO5
Chemical Name:
Acifluorfen
Synonyms:
Benzoic acid,5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitro-;5-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid;Acifluorfen;2-Nitro-5-(2-chloro-4-trifluoromethylphenoxy)benzoic acid;3-Carboxy-2′-chloro-4′-trifluoromethyl-4-nitrodiphenyl ether;PPG 847;Acifluorfene;Acifluorfen H;94128-04-8
Categories:
Agrochemicals > Herbicides

Description

A diphenyl ether, is a combustible, off-white, light tan or brown solid.

Solid

Acifluorfen is a member of the class of benzoic acids that is 2-nitrobenzoic acid in which the hydrogen at position 5 is replaced by a 2-chloro-4-(trifluoromethyl)phenoxy group. It is a herbicide used for the post-emergence control of a variety of annual broadleaf weeds. It has a role as a herbicide, an agrochemical and an EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor. It is a member of benzoic acids, an organochlorine compound, an organofluorine compound, an aromatic ether, a monocarboxylic acid and a C-nitro compound.|Acifluorfen is a protoporphyrinogen oxidase inhibitor.

Acifluorfen Basic Attributes

Molecular Weight：

361.66

Exact Mass：

361.66

EC Number：

256-634-5

UNII：

OI60IB203A

DSSTox ID：

DTXSID0020022

HScode：

2918990027

Characteristics

PSA：

92.4

XLogP3：

3.70

Appearance：

Solid

Density：

1.26 at 23 deg C

Melting Point：

150 °C

Boiling Point：

>100 deg C /47% WATER SOLUTION/

Flash Point：

209.2±28.7 °C

Refractive Index：

1.576

Water Solubility：

>54.2 [ug/mL]

Storage Conditions：

0-6°C

Vapor Pressure：

<1.3X10-3 mPa.

Safety Information

Packing level：

III

Transport codes：

UN 3077

wgk germany：

hazard class code：

22-38-41-50/53

safety instructions：

24-39-60-61

RTECS Number：

DG5643070

Marks：

Xn;N,N,Xn

Stability/Shelf Life：

Stable in acid and alkaline media, pH 3 to pH 9 (40 deg C). /Acifluorfen/

Precautionary statement(s)：

P273-P280-P305 + P351 + P338-P501

Hazard Statements：

H302-H315-H318-H410

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P362, P391, and P501|Aggregated GHS information provided by 163 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE. (See all compounds classified as Herbicides.)

MeSH Entry Terms：

5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoate

Acifluorfen Use and Manufacturing

Methods of Manufacturing

Using meta-hydroxybenzoic acid as raw material, equimolar 3, 4-dichlorobenzotrifluoride and meta-hydroxybenzoic acid are reacted at 138～144℃ for 22h in the presence of KOH with dimethyl sulfoxide as solvent to produce 3 -(2-Chloro-4-trifluoromethylphenoxy)benzoic acid. Then in the methylene chloride solvent, potassium nitrate-sulfuric acid is used for nitration reaction to generate acifluorfen. Then react with equimolar NaOH to form sodium salt. Using m-cresol as raw material, equimolar 3, 4-dichlorobenzotrifluoride and m-cresol potassium salt are reacted in a solvent at 149～155℃ to produce 3-(2-chloro-4-trifluoromethyl) Benzene is then oxidized in the presence of a catalyst and acetic acid with air at 94～96℃ to obtain 3-(2-chloro-2-trifluoromethylphenoxy)benzoic acid. The mixed acid is nitrated at 45°C in the presence of solvent and vinegar rod to obtain acifluorfen, and then reacted with equimolar NaOH to form sodium salt. Using 3-chloro-4-hydroxybenzotrifluoride as a raw material, equimolar 3-chloro-4-hydroxybenzotrifluoride and 5-chloro-2-nitrobenzoic acid in the solvent DMSO, potassium carbonate and nitrogen protection, in Reaction at room temperature to generate acifluorfen.

Uses

It is a contact herbicide. It is used for early post-emergence treatment and can be absorbed by weeds, stems, and leaves.

Manufacturing Info：

Benzoic acid, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitro-: ACTIVE

Use Classification：

Agrochemicals -> Herbicides

Computed Properties

Molecular Weight:361.65
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:360.9964845
Monoisotopic Mass:360.9964845
Topological Polar Surface Area:92.4
Heavy Atom Count:24
Complexity:484
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

1,2-Dichloroethane

Potassium hydroxide

Dimethyl sulfoxide

Nitrogen

Downstream Products

Benzoyl chloride

Recommended Suppliers of Acifluorfen

Shanghai Lonwin Chemical Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of CHEMICALS,REAGENTS

High quality Acifluorofen CAS NO.50594-66-6

CAS No.: 50594-66-6

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Weiyel Inc Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of reference material,reference standards,Reference Standard Materials,ICP & ICP-MS Single/Mix Standards,Analytical standards,Lab reagents,Lab Chemicals,Fine chemicals,Bioreagents

Acifluorfen in Acetone

CAS No.: 50594-66-6

Inquiry