Acifluorfen sodium

383.64

382.97800

263-560-7

6H07I1G902

2588

DTXSID7023853

Dry form is light yellow|White powder|Yellow; as aqueous solution yellow to brown|Dark liquid (40% active ingredient)

29252900

95.18000

3.94600

White crystalline powder.

1.26 g/cm³ @ Temp: 23 °C

>100 °C

>100 °C

209.2ºC

In water (unbuffered) 62.07, (pH 7) 60.81, (pH 9) 60.7 (all in g/100 g, 25 deg C

Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water.

<1.3X10-3 mPa.

Oral-Rat LD50: 1300 mg/kg

Combustion produces toxic nitrogen oxides, fluorides and chloride gases

Dry form ... with a mildly antiseptic odor|Odorless

Henry's Law constant = 6.03X10-11 atm-cu m/mol at 25 °C (est) /Acifluorfen/

pKa = 3.86|pKa = 2.07 (est) /Acifluorfen/

MP: (dry) 274-278 °C (decomp). Bulk density = 0.5-0.5|Light brown solid. VP: 0.01mPa (20 °C). Solubility at 25 °C: acetone 600 g/kg, ethanol 500 g/kg, dichloromethane 50 g/kg, xylene, kerosene <10 g/kg /Acifluorfen/|MW: 261.7; MP: 142-160 °C; density: 1.546. Solubility in water 120 mg/L (23-25 °C)(Tech) /Acifluorfen/|log Kow = 3.70 /Acifluorfen/|Hydroxyl radical reaction rate constant = 8.66X10-13 cu cm/molec-sec at 25 °C (est) /Acifluorfen/

Water soluble.

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

Noncorrosive to equipment under normal use conditions.

2588

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Stable in acid and alkaline media, pH 3 to pH 9 (40 deg C). /Acifluorfen/

P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P362, P391, P501

H302

Must be disposed of by special means, e.g. suitable incineration, in accordance with local regulations.|SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Pesticide Disposal: ...If these wastes cannot be disposed of according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste representatives at the nearest EPA Regional Office for Guidance. Container Disposal: Plastic containers: Triple rinse or equivalent. Then offer for recycling or reconditioning, or puncture and dispose of in a sanitary landfill, or by incineration, or, of allowed by state and local authorities, by burning. If burned, stay out of any smole. Bulk/mini0bulk Containers: Re-usable containers should be returned to the point of purchase for cleaning and refilling because the container must be thoroughly cleaned befor refilling. /Storm Herbicide and Ultra Blazer Herbicide/|Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal.|Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Do cut or puncture other empty pesticide containers made of metal or plastic to prevent someone from reusing them. Wrap the empty container and put it in the trash after you have rinsed it.

Strong oxidizers. Avoid contact with all sources of ignition.

USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Sodium Acifluorfen. The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of February 27, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P302+P352, P305+P351+P338, P310, P321, P330, P332+P313, P362, P391, and P501|Aggregated GHS information provided by 34 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P301+P310, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P312, P314, P321, P322, P330, P332+P313, P337+P313, P362, P363, P391, P403+P233, P405, and P501

Personal Protection Equipment (PPE): Applicators and other handlers must wear: long-sleeved shirt and long pants, chemical -resistant gloves made out of any water-proof material, shoes plus socks, protective eyewear, and chemical-resistant headgear for overhead exposure. Discard clothing and other absorbent materials that have been drenched or heavily contaminated iwth this product's concentrate. Do not re-use them. When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides (40 CFR 170.240 (d) (4-6)), the handler PPE requirements may be reduced or modified as specified in the WPS./Ultra Blazer Herbicide/|Personal Protection Equipment (PPE): Applicators and other handlers must wear: long-sleeved shirt and loong pants, waterproof gloves, shoes plus socks, and protective eyewear. Discard clothing and other absorbent materials that have been drenched or heavily contaminated iwth this product's concentrate. Do not re-use them. /Storm Herbicide/|Chemical-resistant apron when cleaning equiptment, mixing, or loading. Chemical resistant-gloves. Protective eyewear.

This chemical is a combustible solid but does not easily ignite. Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers. Poisonous gases are produced in fire including nitrogen oxides, carbon monoxide, chlorides, and fluorides. If material of contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increase in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156.

Steps to be taken in case material is released or spilled: Dike and contain the spill with inert material (sand, earth, etc.) and transfer liquid and solid diking material to separate containers for disposal. ... Keep the spill out of all sewers and open bodies of water. /Storm Herbicide and Ultra Blazer Herbicide/|Large spillages should be dammed-off and pumped into containers; soak up remainder with absorbent material and dispose of in accordance with local regulations.|If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label.|After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide. To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash.

Agricultural Use Requirements. Use this product only in accordance with its labeling and with the Worker Protection Standard (WPS), 40 CFR part 170. ... Do not enter or allow worker entry into treated areas during the restricted-entry interval (REI) of 48 hours. PPE required for early entry to treated areas that is permitted under the WPS and that involves contact with anything that has been treated, such as plants, soil, or water, is: coveralls, waterproof gloves,shoes plus socks, and protective eyewear and chemical resistant headgear for overhead exposure (Ultra Blazer only) /Storm Herbicide and Ultra Blazer Herbicide/|Follow the manufacturer's instructions for cleaning and maintaining personal protective equipment (PPE). If no such instructions for washables, use detergent and hot water. Keep and wash PPE separately from other laundry. /Storm Herbicide and Ultra Blazer Herbicide/|Users should: wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet; remove clothing immediately if pesticide gets inside, then wash thoroughly an put on clean clothing; and remove personal protective equipment immediately after handling this product; wash the outside of gloves before removing; as soon as possible, wash thoroughly and change into clean clothing. /Storm Herbicide and Ultra Blazer Herbicide/|If in eyes hold eye open and rinse slowly and gently with water for 15-20 minutes, remove contact lenses, if present, after first 5 minutes, then continue rinsing eye, and call a poison control center or doctor for treatment advice. If on skin or clothing take off contaminated clothing, rinse skin immediately with plenty of water for 15-20 minutes, and call a poison control center or doctor for treatment advice. /Storm Herbicide and Ultra Blazer/|For more Preventive Measures (Complete) data for ACIFLUORFEN-SODIUM (7 total), please visit the HSDB record page.

Acifluorfen may be classified as a pesticide, solid, toxic nos. It would then fall in Hazard Class 6.1 and Packing Group III. This requires a "keep away from food" label.

URBAN/SUBURBAN: During a sampling period from October 1996 through September 1997, acifluorfen (the active ingredient of acifluorfen-sodium) was detected (detection limit = 0.1 to 0.2 ug/cu m) in 1 of the 634 (222 rainfall, 124 dry deposition and 228 air) samples collected over four sites within Johnson County, Iowa(1). The sample location/type was not identified. These sites reflect rural (260 acres of farmland 3 miles from Iowa City), urban (central Iowa City), regional (Macbride recreational park 10 miles from both rural and urban settings) conditions, and Oakdale laboratory control representing the 3 previous sites(1).

moderately toxic

LD50 Rat oral 1,300 mg/kg|LD50 Rat male oral 2,025 mg/kg, and for female 1,370 mg/kg /Acifluorfen/|LD50 Rat (CF Nelson) male oral 1,540 mg/kg[EPA/Office of Pollution Prevention and Toxics; High Production Volume Information System (HPVIS) on Benzoic acid, 5-|LD50 Mouse male oral 2,050 mg/kg, and for female 1,370 mg/kg /Acifluorfen/|For more Non-Human Toxicity Values (Complete) data for ACIFLUORFEN-SODIUM (7 total), please visit the HSDB record page.

/OTHER TERRESTRIAL SPECIES/ Non-toxic to bees. /Acifluorfen/

Acifluorfen-sodium's production may result in its release to the environment through various waste streams; it's use as a herbicide(1) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Acifluorfen-sodium is highly dissociated at typical soil pH to acifluorfen(1). Adsorption of this anion form is affected by soil type, pH, soil organic carbon content and soil iron content(3). Based on a classification scheme(2), a Koc range of 44 to 684(4,5), indicates that acifluorfen is expected to have very high to low mobility in soil(SRC). The pKa of aciflurofen-sodium is 3.86(4), indicating that this compound will primarily exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(6). Volatilization of acifluorfen from moist soil surfaces is not expected to be an important fate process(SRC) since anions do not volatilize. Acifluorfen is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.5X10-6 mm Hg(SRC), determined from a fragment constant method(7). An aerobic biodegradation half-life range in soil of 108-200 days for acifluorfen(3) indicates that biodegratation is not an important environmental fate process in soil(SRC). However, under anaerobic conditions, a half-life of 30 days has been reported(3).|AQUATIC FATE: Acifluorfen-sodium dissociates in the environment to acifluorfen(SRC). Based on a classification scheme(1), a Koc range of 44-684(3,6) indicates that acifluorfen is expected to adsorb to some suspended solids and sediment(SRC). A pKa of 3.86(6) indicates acifluorfen-sodium will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 3.70(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Photolysis in water occurs and it is rapidly degraded with a half-life of about 2 hours(6). An aerobic biodegradation half-life in water of 117 days for acifluorfen(2) indicates that biodegradation is not an important environmental fate process in water(SRC). However, under anaerobic conditions, a half-life of 2.75 days has been reported(2).|ATMOSPHERIC FATE: Acifluorfen-sodium dissociates in the environment to acifluorfen(SRC). According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), acifluorfen, which has an estimated vapor pressure of 1.5X10-8 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase acifluorfen is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 days(SRC), calculated from its rate constant of 8.7X10-13 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Photolysis in water occurs with a half-life of about 2 hours reported(4); therefore, the active ingredient may be susceptible to direct photolysis(SRC).

Acifluorfen-sodium dissociates in the environment to acifluorfen(SRC). The rate constant for the vapor-phase reaction of acifluorfen with photochemically-produced hydroxyl radicals has been estimated as 8.7X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 18 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Acifluorfen-sodium is hydrolytically stable in the dark(2). Acifluorfen-sodium is reported as stable to photolysis in soil(2) although photolytic degradation on the soil surface has been indicated(3). Using a loamy sand from Sauk County, WI (OM 2.7%, pH 5.4, sand 87%, silt 8%, clay 5%, CEC 7.2 mequiv/100g), 28 ug of acifluorfen was exposed to a xenon lamp using a quartz diffuser, first-order rate constants of 6.90/hr, 1.00/hr and 2.22/hr were measured for irradiated moist soil (maintained at moisture content of 75%), irradiated air-dried and dark control moist soil test setups, corresponding to half-lives of 100 hours, 690 hours, and 313 hours, respectively(4). No degradation was observed under dark, air-dried soil conditions(4). Decrease in air-dried soils may be attributed to microbial activity(4). Photolysis in water occurs and it is rapidly degraded with a half-life about 2 hours, forming mainly CO2(3). The photodegradation of acifluorfen in water proceeds via decarboxylation followed by dehalogenation followed by substitution of the chlorine group by hydroxyl or hydrogen groups and ending with cleavage of ether linkage, resulting in phenols(5). The trifluoro functional group was not affected nor was reduction of the nitro group observed(5). UV absorption maxima of acifluorfen (solvent) are 274 nm (n-hexane), 287 nm (methanol), 288 nm (acetonitrile) and 310 nm (water)(6).|Irradiation (peak outputs at 300 and 360 nm) of a 1X10-4 M aqueous solution of acifluorfen-sodium for 7 hours resulted in the decomposition of about 51% of the herbicide (first-order rate constant = 0.105 /hour), yielding 2-chloro-1-(4-nitrophenoxy)-4-trifluoromethylbenzene as the only product(1). The photolysis rate constant for acifluorfen-sodium in soil has been observed to be 0.151 /day(2). This corresponds to a photolysis half-life of 4.6 days in soil(SRC).|Photodegradation half-life of about 22 hours.

The pKa of acifluorfen-sodium is 3.86(1) and it dissociates in the environment to acifluorfen(SRC). An estimated BCF of 3 was calculated in fish for acifluorfen(SRC), using a log Kow of 3.70(2) and a regression-derived equation(3). According to a classification scheme(4), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

112.20 L/kg|The pKa of acifluorfen-sodium is 3.86(4). Acifluorfen-sodium is highly dissociated in moist soil at environmental pH to acifluorfen(1). Adsorption of this anion form is affected by soil type, pH, soil organic carbon content and soil iron content(2). Acifluorfen forms complexes with divalent and trivalent cations(1). Acifluorfen sorption is a nonequilibrium and time-dependent process and therefore mobility in soil is affected by the rate as well as the extent of sorption(1). An adsorption Koc range of 44-684(4,5) (Kd 0.13-1.98) has been reported(4). According to a classification scheme(3), these Koc values suggest that acifluorfen is expected to have very high to low mobility in soil. Acifluorfen is weakly and reversibly adsorbed(6) and therefore accumulation in soil does not occur(5). A desorption Koc range of 131-1955, Kd 0.39-4.6, has been reported(4).

The pKa of acifluorfen-sodium is 3.86(1). Acifluorfen-sodium dissociates in the environment to acifluorfen(SRC). The estimated pKa for acifluorfen is 2.07(2) indicating that it will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(3). The pKa indicates acifluorfen-sodium will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(SRC). Acifluorfen is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.5X10-8 mm Hg(SRC), determined from a fragment constant method(4).

GROUNDWATER: Acifluorfen, the active ingredient of the herbicide acifluorfen-sodium, was detected at a concentration of 0.60906 ug/L in one of seventy-seven groundwater sites sampled in the Arkansas delta aquifer between July 29 and September 23, 1996, in areas of Jefferson, Phillips and Desha counties(1). The compound was previously reported as detected in studies conducted by the Arkansas Water Resources Center (3 positive listings) and the Arkansas Dept of pollution Control and Ecology (1 positive listing) groundwater surveys(1).|DRINKING WATER: Twelve water supply intakes from mostly rural Piedmont and coastal regions of North Carolina were monitored over a 16-month period beginning in March 1995 for the presence of the active ingredient of acifluorfen-sodium, acifluorfen(1). The compound was not detected in these surface water samples(1).|RAIN/SNOW/FOG: During a sampling period from October 1996 through September 1997, acifluorfen (the active ingredient of acifluorfen-sodium) was detected (detection limit = 0.01 to 0.2 ug/L) in 1 of the 634 (222 rainfall, 124 dry deposition and 228 air) samples collected over four sites within Johnson County, Iowa(1). The sample location/type was not identified. These sites reflect rural (260 acres of farmland 3 miles from Iowa City), urban (central Iowa City), regional (Macbride recreational park 10 miles from both rural and urban settings) conditions, and an Oakdale laboratory control representing the 3 previous sites(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 3,018 workers (359 of these are female) are potentially exposed to the active ingredient of acifluorfen-sodium, acifluorfen, in the US(1). The NOES Survey does not include farm workers. Occupational exposure to acifluorfen-sodium may occur through inhalation and dermal contact with this compound at workplaces where acifluorfen-sodium is produced or used(SRC). Use data indicate that the general population may be exposed to acifluorfen-sodium via dermal contact with consumer products containing this compound(SRC).

Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE. (See all compounds classified as Herbicides.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

Rapidly metabolized in plants to glucuronides, and homoglutathione and cysteine conjugates. /Acifluorfen/

Acts by inhibition of protoporphyrinogen oxidase.

If swallowed call a poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give anything by mouth to an unconscious person. If inhaled move person to fresh air. If person is not breathing, call 911 or an ambulance, then give artificial respiration ... Call a poison control center or doctor for further treatment advice. Note to Physician: Probable mucosal damage may contraindicate the use of gastric lavage. /Storm Herbicide and Ultra Blazer Herbicide/

/SIGNS AND SYMPTOMS/ DANGER: corrosive. Causes irreversible eye damage. Harmful if swallowed or absorbed through the skin...Prolonged or frequently repeated skin contact may cause allergic reactions in some individuals. /Storm Herbicide and Ultra Blazer/

5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrobenzoate

Liquid concentrate of the sodium salt.|Storm (1.33 lb/gal acifluorfen-sodium + 2.67 lb/gal bentazon); Galaxy (0.67 lb/gal acifluorfen-sodium + 3.0 lb/gal bentazon).|STORM HERBICIDE Active Ingredient 29.2%, Sodium bentazon 13.4% Sodium acifluorfen|KLEERAWAY GRASS & WEED KILLER 2 Active Ingredient 0.5% Glyphosate, isopropylamine salt, 0.12% Sodium acifluorfen|For more Formulations/Preparations (Complete) data for ACIFLUORFEN-SODIUM (7 total), please visit the HSDB record page.

Benzoic acid, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitro-, sodium salt (1:1): ACTIVE

EC/GLC methods sensitive to 0.01 ppm exist for the parent compound, the free acid, the methyl ester, and any other compounds which can be converted to the methyl ester (BASF Corp).|Method: USGS-NWQL O-1131-95; Procedure: high performance liquid chromatography using ultraviolet spectrometry; Analyte: acifluorfen-sodium; Matrix: filtered natural-water; Detection Limit: 0.008 ug/L.