Calcium acetate

158.17

157.989

200-540-9

Y882YXF34X

1092

DTXSID0020234

C47429

COLORLESS CRYSTALS|Rod-shaped crystals|White, hydrogroscopic, crystalline solid

V - Various

29152990

80.3

0.02760

white Powder

150 g/cm³

160 °C (decomp)

117.1ºC at 760 mmHg

160°C

INDEX OF REFRACTION: 1.55

H2O: 1 M at 20 °C, clear, colorless

Calcium acetate is stable although very hygroscopic, and so the monohydrate is the common form. It decomposes on heating (above 1608℃) to form calcium carbonate and acetone.
Store in well-closed airtight containers.

Intravenous-mouse LD50: 52 mg/kg; Intraperitoneal-mouse LD50: 75 mg/kg

Thermal decomposition spicy irritating smoke

SLIGHT ODOR OF ACETIC ACID

6,0-9,0 (10 % aqueous solution)

Decomp above 160 °C to acetone and calcium carbonate|Soluble in water; slightly soluble in alcohol; needles, granules, or powder form. /Monohydrate/|Long transparent needles. Loses water on standing in air, forming the monohydrate. /Dihydrate/|Brown, gray, or white powder, amorphous or crystalline; slightly bitter taste, slight odor of acetic acid. Decomposes on heating. Combustible. /Monohydrate/

1

36/37/38

26-36

AF7525000

Xi

Treasury is ventilated, low temperature and dry; stored separately from food materials

Stable. Non-flammable. Incompatible with strong oxidizing agents.

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

H315

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).|Calcium acetate is an indirect food additive for use as a component of resinous and polymeric coatings.|Calcium acetate used as a sequestrant is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Combustible under specific conditions.

Not Classified

Use water spray, powder.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. Wash away remainder with plenty of water.

Separated from strong acids. Dry. Well closed.

A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.

The substance is irritating to the eyes, skin and respiratory tract.

NO open flames.

PREVENT DISPERSION OF DUST!

Use local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles.

highly toxic

Oral, rat: LD50 = 4280 mg/kg. Symptoms of overdose include mild hypercalcemia (constipation; loss of appetite; nausea and vomiting), and severe hypercalcemia (confusion; full or partial loss of consciousness; incoherent speech).

Concurrent administration /of calcium acetate and oral tetracyclines/ may decrease the bioavailability of tetracyclines.

LD50 Mouse ip 75 mg/kg|LD50 Mouse iv 52 mg/kg

Calcium acetate is one of a number of calcium salts used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.|FDA Label

... Used to restrict phosphate absorption in patients with chronic renal failure and oxalate absorption in patients with inflammatory bowel disease.|Calcium acetate is indicated in patients with end-stage renal failure to lower serum phosphate concentrations. It does not promote aluminum absorption. /Included in US product labeling/

Except under special circumstances, this medication /calcium acetate/ should not be used when the following medical problem exists: hypercalcemia (calcium acetate may exacerbate the condition).|Concurrent use /with digitalis glycosides/ is not recommended because calcium acetate may cause hypercalcemia, which could precipitate cardiac arrhythmias.

Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration.|Calcium acetate when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces.

Calcium acetate and other calcium salts are phosphate binders. They work by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Poison by intravenous and intraperitoneal routes.

acetic acid, calcium salt

The substance can be absorbed into the body by inhalation and by ingestion.

Cough. Sore throat.

Redness.

Redness. Pain.

Grades: Technical (80% basis); reagent; CP; pure; brown; gray; FCC /Monohydrate/|Powder: food, pharmaceutical grades; agglomerated, technical, USP, FCC grades; purified grade

Agriculture, forestry, fishing and hunting|Acetic acid, calcium salt (2:1): ACTIVE|/EFFECTIVE LEVEL OF CALCIUM ACETATE AGAINST ROPE IS 0.4-1.0%./|FEMA NUMBER 2228

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Food additives|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Food Additives -> ACIDITY_REGULATOR; PRESERVATIVE; STABILIZER; -> JECFA Functional Classes|Cosmetics -> Viscosity controlling

Food Additives -> ACIDITY_REGULATOR; PRESERVATIVE; STABILIZER;