Dimethylformamide dimethyl acetal
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Dimethylformamide dimethyl acetal
structure -
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CAS No:
4637-24-5
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Formula:
C5H13NO2
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Chemical Name:
Dimethylformamide dimethyl acetal
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Synonyms:
Methanamine,1,1-dimethoxy-N,N-dimethyl-;Trimethylamine,1,1-dimethoxy-;1,1-Dimethoxy-N,N-dimethylmethanamine;1,1-Dimethoxytrimethylamine;N-(Dimethoxymethyl)dimethylamine;Dimethoxy(dimethylamino)methane;Methyl-8;(Dimethylamino)formaldehyde dimethyl acetal;(Dimethylamino)dimethoxymethane;Dimethoxy-N,N-dimethylmethylamine;DMF dimethyl acetal;N,N-Dimethylformamide dimethyl acetal;Dimethylformamide dimethyl acetal;α,α-Dimethoxytrimethylamine;DMFDMA;N-(Dimethoxymethyl)-N,N-dimethylamine;(Dimethoxymethyl)dimethylamine;Dimethoxy-N,N-dimethylmethanamine;Dimethyl dimethylformamide acetal;N,N-Dimethyl-1,1-bis(methyloxy)methanamine;N,N-Dimethyl(dimethoxymethyl)amine;N,N-Dimethylformamido dimethyl acetal;637765-94-7
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CAS No:
Description
clear colourless liquid
Liquid
N,N-dimethylformamide dimethyl acetal is an acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applications It has a role as a chromatographic reagent. It is an acetal and a tertiary amino compound. It derives from a N,N-dimethylformamide.
Dimethylformamide dimethyl acetal Basic Attributes
119.16200
119.16
225-063-3
DF7CTT5QPH
DTXSID3063540
29225000
Characteristics
21.70000
0.2
Liquid
0.8990 g/cm3 @ Temp: 20 °C
101-102 °C
107-108 °C @ Press: 763 Torr
7ºC
1.3972
hydrolysis
Flammables area
LD50 orally in Rabbit: > 5000 mg/kg
Safety Information
II
3
UN 3271
1
R11; R20; R36/38
S16-S26-S36/37/39
F; Xn
Stable under normal temperatures and pressures.
P210-P261-P280-P304 + P340 + P312-P305 + P351 + P338-P370 + P378
H225-H315-H317-H319-H332-H335
|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 202 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Dimethylformamide dimethyl acetal Use and Manufacturing
A process for the synthesis of N, N-dimethylformamide dimethylacetal comprising the steps of:(1) N, N-dimethylformamide was heated to 70 ° C, incubated with dimethyl sulfate, and reacted at the end of the dropwise addition for 4 hours to obtain an imine complex, Cooled to room temperature, and the molar ratio of N, N-dimethylformamide and dimethyl sulfate is 1: 1;(2) the solid sodium methoxide added to 200 solvent oil, ultrasonic dispersion, adjust the temperature to 25 , Insulation, dropping imine complex, after the end of the reaction for 2h, filtration, the filtrate under normal pressure fractionation, A fraction of 105-108 ° C was collected to give N, N-dimethylformamide dimethyl acetal in a yield of 75.3percentPurity of 97percent; where the molar ratio of sodium methoxide to imine complex is 1: The synthesis method of N, N-dimethylformamide dimethyl acetal of Example 6 was the same as in except that the organic solvent of this example was a mixed solvent oil: D40 solvent oil, D60 solvent oil, 260 (Volume ratio: 2: 1: 1) to give N, N-dimethylformamide dimethylacetal as a yield of 85.4percent and a purity of 97percent.Separately, 440 g of anhydrous methanol and 111 g (2.05 mol) of sodium methoxide are added to a 1-liter three-necked flask under a nitrogen atmosphere and cooled to 0 to 5 ° C. 400.4 g (2.01 mol) of the immune complex was dropped for 3 hours while maintaining the temperature at 5 DEG C or lower, and the mixture was stirred at room temperature for 20 hours. The methanol was removed by distillation under atmospheric pressure and distilled under vacuum to obtain 141.3 g (yield 59percent) of colorless liquid dimethylformamide dimethylacetal.
1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110伪 enzymes.
Dyes
Paper products
Paper manufacturing|Methanamine, 1,1-dimethoxy-N,N-dimethyl-: ACTIVE
Computed Properties
Molecular Weight:119.16
XLogP3:0.2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:119.094628657
Monoisotopic Mass:119.094628657
Topological Polar Surface Area:21.7
Heavy Atom Count:8
Complexity:52.4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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Dimethylformamide dimethyl acetal
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