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Lafutidine

Lafutidine structure

CAS No:
118288-08-7
Formula:
C22H29N3O4S
Chemical Name:
Lafutidine
Synonyms:
Acetamide,2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]-,(+)-;Acetamide,2-[(2-furanylmethyl)sulfinyl]-N-[4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-butenyl]-,(Z)-(+)-;Acetamide,2-[(2-furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-butenyl]-,(+)-;(+)-2-[(2-Furanylmethyl)sulfinyl]-N-[(2Z)-4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-2-buten-1-yl]acetamide;FRG 8813;Laflutidine;(+)-2-(Furfurylsulfinyl)-N-[(Z)-4-[[4-(piperidinomethyl)-2-pyridyl]oxy]-2-butenyl]acetamide;(+)-Lafutidine;Lafutidine;Stogar;Protecadin;Lafukem;143375-16-0;169899-20-1
Categories:
Biochemical Engineering > Inhibitors

Description

Lafutidine is a second generation of H2-receptor antagonist. H2-receptor antagonist can strongly inhibit gastric acid secretion compared with conventional drugs such as antacids. Unlike conventional H2-receptor antagonist, lafutidine inhibits gastric acid secretion during daytime as well as nighttime in clinical studies in humans. Lafutidine also has gastroprotective activity independent of its acid antisecretory efficacy, preventing noxious agent-induced gastric mucosal injury and accelerating

Lafutidine Basic Attributes

Molecular Weight：

431.55

Exact Mass：

431.55

EC Number：

1312995-182-4

DSSTox ID：

DTXSID0046434

HScode：

29349990

Characteristics

PSA：

104

Density：

1.252±0.06 g/cm3(Predicted)

Melting Point：

92.7-94.9°

Boiling Point：

704.2±60.0 °C(Predicted)

Flash Point：

379.7±32.9 °C

Refractive Index：

1.599

Safety Information

hazard class code：

R36/37/38:Irritating to eyes, respiratory system and skin .

safety instructions：

24/25

Marks：

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Lafutidine Use and Manufacturing

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion

Computed Properties

Molecular Weight:431.6
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:11
Exact Mass:431.18787759
Monoisotopic Mass:431.18787759
Topological Polar Surface Area:104
Heavy Atom Count:30
Complexity:569
Undefined Atom Stereocenter Count:1
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not yet clear

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lafutidine Capsules
Ingredients	The main ingredient of this product is lafutidine, and its chemical name is: (±)-2-[2-(furanmethyl)sulfinyl]-N-[4-[4-(piperidinylmethyl)-2-pyridinyl]oxy-(Z)-2-butenyl]acetamide. Molecular weight: C22H29N3O4S
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	5mg
Manufacturer	Youcare Pharmaceutical Group Co., Ltd.

Lafutidine
Manufacturer	Sichuan Xin Kai Yuan Pharmaceutical Co., Ltd.

Lafutidine Tablets
Ingredients	The main ingredient of this product is lafutidine, and its chemical name is: (±)-2-[2-(furanmethyl)sulfinyl]-N-[4-[4-(piperidinylmethyl)-2-pyridinyl]oxy-(Z)-2-butenyl]acetamide.
Indication	Other H2 receptor blockers can bind to cytochrome P450, thereby reducing the activity of liver microsomal drug-metabolizing enzymes. Therefore, caution should be exercised when this product is used in combination with warfarin, phenytoin sodium, theophylline, phenobarbital, diazepam or propranolol and cimetidine.
Specifications	10mg
Manufacturer	Jiangsu Runbang Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Suzhong Pharmaceutical Group Co., Ltd.

China
Active
Anhui Biochem Pharmaceutical Co., Ltd.

China
Active
China Resources Double-Crane Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Lafutidine

Dayang Chem (Hangzhou) Co.,Ltd Contact Supplier

CN
4 YRS

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Lafutidine Manufacturer/High quality/Best price/In stock

CAS No.: 118288-08-7

Grade: Industrial Grade

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Hangzhou KieRay Chem Co.,LTD Contact Supplier

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5 YRS

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Manufactory Supplier of fine chemicals,pharmaceutical materials

Lafutidine

CAS No.: 118288-08-7

Grade: industrial Grade

Content: 98%

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Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

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Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Lafutidine 118288-08-7

CAS No.: 118288-08-7

Grade: Pharmaceutical Grade

Content: 99%

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