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Phylloquinone

Phylloquinone structure

CAS No:
84-80-0
Formula:
C31H46O2
Chemical Name:
Phylloquinone
Synonyms:
1,4-Naphthalenedione,2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl]-;Phylloquinone;1,4-Naphthalenedione,2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-,[R-[R*,R*-(E)]]-;1,4-Naphthalenedione,2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl]-;2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl]-1,4-naphthalenedione;Antihemorrhagic vitamin;Mephyton;2-Methyl-3-phytyl-1,4-naphthoquinone;Mono-Kay;Phytomenadione;Phytonadione;Phytylmenadione;Vitamin K1(20);α-Phylloquinone;Konakion;trans-Phylloquinone;2′,3′-trans-Vitamin K1;Synthex P;Kephton;Kinadion;Monodion;Combinal K1;Kativ N;AquaMEPHYTON;Kaywan;Phylloquinone K1;Phytylmenaquinone;Pediatrico;Orakay;Veta K1;Veda K1;NSC 270681;Kanakion;Amri-K;Haemokion;Kenadion;Reconval;10485-69-5;15973-57-6;50926-17-5
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

It appears as yellow to orange transparent viscous liquid and is odorless with the relative density being 0.967 and the refractive index being nD251.525~1.528. It is easily soluble in chloroform, ether and vegetable oil, slightly soluble in ethanol and insoluble in water. It is easily to be decomposed when exposed to light and with being decomposed upon being heated to 120 ℃. Yellow Oil Phylloquinone is an odorless yellow viscous oil or crystals.

Phylloquinone Basic Attributes

Molecular Weight：

450.7

Exact Mass：

450.70

BRN：

2568816

EC Number：

201-564-2

HScode：

29362900

Characteristics

PSA：

34.1

XLogP3：

9.3

Appearance：

viscous liquid

Density：

0.964 g/cm³ @ Temp: 25 °C

Melting Point：

-20 °C

Boiling Point：

140-145 °C @ Press: 1 x 10^-3 Torr

Flash Point：

>230 °F

Refractive Index：

1.527

Water Solubility：

Miscible with dehydrated alcohol, acetone, petroleum ether, hexane, dioxane, chloroform, ether,benzene and vegetable oils. Immiscible with water.

Storage Conditions：

2-8°C

Specific rotation：

D25 -0.28° (dioxane)

Odor：

Odorless

PH：

SOLN OF 1 PART VIT K1 & 20 PARTS ALC IS NEUTRAL TO LITMUS

Safety Information

Transport codes：

UN1170 - class 3 - PG 2 - Ethanol, solution

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-37/39-24/25

RTECS Number：

QJ5800000

Marks：

Stability/Shelf Life：

Phytonadione is stable to heat and moisture and may be autoclaved.

Precautionary statement(s)：

P273, P501

Hazard Statements：

H413

Phylloquinone Use and Manufacturing

Methods of Manufacturing

In the presence of zinc, o-methylnaphthoquinone and acetic anhydride are reduced and acetylated to form acetylated menadione; then hydrolyzed in ammonia, and then catalyzed by boron trifluoride in ether to condense with plant alcohols to obtain dihydrovitamin K1 ; Finally, the product is obtained by hydrolysis, oxidation, purification and refining.

Uses

Occurs widely in green plants, algae, photosynthetic bacteria.

Material

Methylnaphthalene

Menadione

Drug Function and Efficacy

Can form prothrombin to maintain normal blood coagulation function. When it is deficient, it causes prothrombin deficiency bleeding.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Vitamin (4) Injection
Ingredients	2ml: Contains: Vitamin A palmitate 2500IU, Vitamin D2200IU, Vitamin E15mg, Vitamin K12mg.
Indication	This product contains vitamin K1 and should not be used in combination with coumarin anticoagulants.
Specifications	2ml
Manufacturer	Xi'an Fenghua Pharmaceutical Co., Ltd.

Enteral Nutrition Emulsion (TP-HE)
Ingredients	This product is a compound preparation, and its components are: protein, fat, saturated fatty acids, polyunsaturated fatty acids, medium-chain triglycerides, carbohydrates, sugar, lactose, water, sodium, potassium, chloride, calcium, magnesium, phosphorus, iron, zinc, copper, manganese, iodide, chromium, molybdenum, fluoride, selenium, vitamin A, vitamin D3, vitamin E, vitamin K1, vitamin B1, vitamin B2, niacinamide, vitamin B6, vitamin B12, pantothenic acid, biotin, folic acid, vitamin C, choline, osmotic pressure, and energy (energy sources: protein, fat, carbohydrates).
Indication	Not yet clear.
Specifications	500ml/bag

Fat-soluble vitamins for injection (Ⅱ)
Ingredients	This product is a fat-soluble vitamin compound preparation. Each 10 ml contains the following components: Vitamin A 0.69 mg; Vitamin D2 10 μg; Vitamin E 6.4 mg; Vitamin K1 0.20 mg; Soybean oil for injection 1 g; Lecithin for injection 0.12 g; Glycerin (anhydrous) 0.22 g; Sodium hydroxide to adjust the pH to about 8.
Indication	This product contains vitamin K, which may interact with anticoagulants such as coumarins and heparin and should not be used together.
Specifications	Compound preparations
Manufacturer	Ma'anshan Fengyuan Pharmaceutical Co., Ltd.

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Registered Holders

SUNNY PHARMTECH INC

United States
Active
ENALTEC LABS PRIVATE LTD

United States
Active
BIOPHORE INDIA PHARMACEUTICALS PVT LTD

United States
Active

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Guide of Phylloquinone

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
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Phylloquinone

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