Vitamin K1
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Vitamin K1
structure -
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CAS No:
84-80-0
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Formula:
C31H46O2
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Chemical Name:
Vitamin K1
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Synonyms:
Kativn K1;Phytomenadione (Vitamin K1);vitamin K1 micro-capsule;PHYLLOQUINONE;PHYTOMENADIONE;PHYTONADIONE;kativn;Kephton
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CAS No:
Description
It appears as yellow to orange transparent viscous liquid and is odorless with the relative density being 0.967 and the refractive index being nD251.525~1.528. It is easily soluble in chloroform, ether and vegetable oil, slightly soluble in ethanol and insoluble in water. It is easily to be decomposed when exposed to light and with being decomposed upon being heated to 120 ℃. Yellow Oil Phylloquinone is an odorless yellow viscous oil or crystals.
Vitamin K1is a fat-soluble, dietary nutrient that is essential for the synthesis of proteins important for blood-clotting, bone metabolism, and cell growth. It is found in the photosynthetic tissues of green, leafy plants, where it acts as an electron acceptor forming part of the electron transport chain of Photosystem I. Vitamin K1also serves as a precursor to vitamin K2and is reported to exhibit anticancer activity in various cell lines.
Yellow Oil
Phylloquinone is an odorless yellow viscous oil or crystals.
ChEBI: Phylloquinone is a member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones. It has a role as a cofactor, a plant metabolite and a human metabolite. It is a vitamin K and a member of phylloquinones.
Vitamin K1 Basic Attributes
450.7
450.70
2568816
201-564-2
TSCA listed
Yellow to Dark Yellow
29362900
Characteristics
34.1
9.3
viscous liquid
0.984 g/mL at 25 °C(lit.)
−20 °C(lit.)
140°C 0mm
>230 °F
n20/D1.527(lit.)
Miscible with dehydrated alcohol, acetone, petroleum ether, hexane, dioxane, chloroform, ether, benzene and vegetable oils. Immiscible with water.
2-8°C
D25 -0.28° (dioxane)
odorless
SOLN OF 1 PART VIT K1 & 20 PARTS ALC IS NEUTRAL TO LITMUS
2-8°C
Safety Information
UN1170 - class 3 - PG 2 - Ethanol, solution
2
Xi
26-37/39-24/25
QJ5800000
Xi
Phytonadione is stable to heat and moisture and may be autoclaved.
P273, P501
36/37/38
Phylloquinone is photosensitive; decomposes in sunlight and is destroyed by alkali hydroxides and reducing agents such as hydrideds and active metals. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
UN1170 - class 3 - PG 2 - Ethanol, solution
Vitamin K1 Use and Manufacturing
In the presence of zinc, o-methylnaphthoquinone and acetic anhydride are reduced and acetylated to form acetylated menadione; then hydrolyzed in ammonia, and then catalyzed by boron trifluoride in ether to condense with plant alcohols to obtain dihydrovitamin K1 ; Finally, the product is obtained by hydrolysis, oxidation, purification and refining.
Occurs widely in green plants, algae, photosynthetic bacteria.
1. It can be used as food supplements. It can be used in infant foods with the usage amount being 420~475μg/kg.2. It belongs to vitamin drugs to be used for the prevention and treatment of vitamin K1 deficiency symptom, low thrombin disease and natural newborn hemorrhagic disease.3. promote blood clotting.4. promote the synthesis of primary liver thrombin.5. increase the intestinal motility and secretion function.
vitamin K1
Labeled Phytonadione, intended for use as an internal standard for the quantification of Phytonadione by GC- or LC-mass spectrometry.
Drug Function and Efficacy
Can form prothrombin to maintain normal blood coagulation function. When it is deficient, it causes prothrombin deficiency bleeding.
Registered Holders
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SUNNY PHARMTECH INC
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United States
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ENALTEC LABS PRIVATE LTD
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United States
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BIOPHORE INDIA PHARMACEUTICALS PVT LTD
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United States
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