 Home > Encyclopedia > Dolutegravir

Dolutegravir

Dolutegravir structure

CAS No:
1051375-16-6
Formula:
C20H19F2N3O5
Chemical Name:
Dolutegravir
Synonyms:
2H-Pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide,N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-,(4R,12aS)-;(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide;GSK 1349572;S/GSK1349572;Dolutegravir;Tivicay;Soltegravir;(4R,9aS)-5-Hydroxy-4-methyl-6,10-dioxo-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-7-carboxylic acid 2,4-difluoro-benylamide;1172581-47-3
Categories:
Biochemical Engineering > Inhibitors

Request for Quotation

Description

Dolutegravir is a second-generation HIV integrase strand transfer inhibitor (INSTI) with an IC50 of 2.7 nM.

Dolutegravir Basic Attributes

Molecular Weight：

419.3787664

Exact Mass：

419.38

EC Number：

809-888-1

Characteristics

PSA：

99.2

XLogP3：

2.4

Appearance：

White to Pale Yellow Solid

Density：

1.53 g/cm3

Melting Point：

190-193ºC

Boiling Point：

669.0±55.0°C at 760 mmHg

Flash Point：

358.4±31.5 °C

Refractive Index：

1.650

Water Solubility：

In water, 95 mg/L at 25 deg C (est)

Storage Conditions：

Store at 25 deg C (77 deg F); excursions permitted 15 deg to 30 deg C (59 deg to 86 deg F)

Vapor Pressure：

1.39X10-17 mm Hg at 25 deg C (est)

PKA：

8.2None

Safety Information

Precautionary statement(s)：

P273, P391, P501

Hazard Statements：

H400

Dolutegravir Use and Manufacturing

Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Drug Function and Efficacy

Inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of reverse transcribed deoxyribonucleic acid (DNA) integration, a key step in the HIV replication cycle

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dotiabalamil tablets
Ingredients	This product is a compound preparation. Each tablet contains 50 mg of dolutegravir sodium (calculated as dolutegravir), 600 mg of abacavir sulfate (calculated as abacavir) and 300 mg of lamivudine.
Indication	This product contains dolutegravir, abacavir, and lamivudine, so the interactions found when these drugs are used alone are related to this product. No clinically significant drug interactions are expected between dolutegravir, abacavir, and lamivudine.
Specifications	50mg/600mg/300mg x 30 tablets

Recommended Suppliers of Dolutegravir

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

GSK1349572

CAS No.: 1051375-16-6

Content: 99.00%

Inquiry
Xi'an Honest BioEngr Co.,Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10,Piracetam,Pregabalin,Ketoprofen,omeprazole,Fullerene C60,Melatonin,Nicotinamide riboside chloride,lactoferrin,Tylosin tartrate,Gentamycin Sulfate,Levamisole HCl,Praziquantel,Ivermectin,GA3,Pepsin,MT2,5 amino 1MQ,selank,semax

Premium-grade Dolutegravir raw material 99% purity, CAS 1051375-16-6 offered at the best market price

CAS No.: 1051375-16-6

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

S/GSK1349572(GSK1349572)

CAS No.: 1051375-16-6

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high purity hot sale Dolutegravir 99% high quality see COA KANBEI

CAS No.: 1051375-16-6

Grade: Industrial Grade

Content: 99%

Inquiry