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Solifenacin succinate

Solifenacin succinate structure

CAS No:
242478-38-2
Formula:
C23H26N2O2.C4H6O4
Chemical Name:
Solifenacin succinate
Synonyms:
Butanedioic acid,compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1);2(1H)-Isoquinolinecarboxylic acid,3,4-dihydro-1-phenyl-,(3R)-1-azabicyclo[2.2.2]oct-3-yl ester,(1S)-,butanedioate (1:1);Solifenacin succinate;Vesicare;Vesikur;YM 67905
Categories:
Biochemical Engineering > Inhibitors

Description

White Solid

Solifenacin succinate is a member of isoquinolines.|A quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE.

Solifenacin succinate Basic Attributes

Molecular Weight：

480.56

Exact Mass：

480.226037

EC Number：

1592732-453-0

UNII：

KKA5DLD701

HScode：

29339900

Characteristics

PSA：

107

XLogP3：

3.67650

Density：

1.24g/cm3

Melting Point：

~145°

Boiling Point：

505.5°C at 760 mmHg

Flash Point：

259.5ºC

Refractive Index：

1.648

Vapor Pressure：

2.41E-10mmHg at 25°C

Collision Cross Section：

201 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

RTECS Number：

NW7136000

GHS Classification：

|Warning|H302 (95.38%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 65 companies from 10 notifications to the ECHA C&L Inventory.

Drug Information

Drug Indication：

Treatment of neurogenic detrusor overactivity|Treatment of myoneurogenic bladder disorders

MeSH：

Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION. (See all compounds classified as Urological Agents.)|Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

MeSH Entry Terms：

2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-,1- azabicyclo(2.2.2)oct-3-yl ester, (R-(R*,S*))-

Solifenacin succinate Use and Manufacturing

Uses

Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.

Use Classification：

Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:480.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:480.22603674
Monoisotopic Mass:480.22603674
Topological Polar Surface Area:107
Heavy Atom Count:35
Complexity:617
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Competitive muscarinic receptor antagonists inhibit overactivity of the detrusor muscle by blocking the muscarinic M3 receptors of bladder smooth muscle, thereby relieving the symptoms of urge urinary incontinence, urgency and frequency of urination associated with overactive bladder.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Solifenacin succinate tablets
Ingredients	Solifenacin succinate.
Indication	The combined use of other drugs with anticholinergic properties may cause more obvious therapeutic effects and side effects. Before stopping the treatment of this product and starting to use other anticholinergic drugs, an interval of about 1 week should be set. The simultaneous use of cholinergic receptor agonists may reduce the efficacy of solifenacin. Solifenacin can reduce the effect of drugs that stimulate gastrointestinal motility, such as metoclopramide and cisapride.
Specifications	5 mg

Solifenacin succinate tablets
Ingredients	Solifenacin succinate.
Indication	The combined use of other drugs with anticholinergic properties may cause more obvious therapeutic effects and side effects. Before stopping the treatment of this product and starting to use other anticholinergic drugs, an interval of about 1 week should be set. The simultaneous use of cholinergic receptor agonists may reduce the efficacy of solifenacin. Solifenacin can reduce the effect of drugs that stimulate gastrointestinal motility, such as metoclopramide and cisapride.
Specifications	5 mg

Solifenacin succinate tablets
Specifications	5mg

See More Related Drugs

Registered Holders

MICRO LABS LTD

United States
Active
OPTIMUS DRUGS PRIVATE LTD

United States
Active
WEIHAI DISU PHARMACEUTICAL CO LTD

United States
Active

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