Spectinomycin hydrochloride
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Spectinomycin hydrochloride
structure -
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CAS No:
21736-83-4
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Formula:
C14H24N2O7.2ClH
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Chemical Name:
Spectinomycin hydrochloride
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Synonyms:
4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-,hydrochloride (1:2),(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-;4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-,dihydrochloride,[2R-(2α,4aβ,5aβ,6β,7β,8β,9α,9aα,10aβ)]-;4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-,dihydrochloride,(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-;Spectinomycin dihydrochloride;Spectinomycin hydrochloride;Stanilo;(+)-Spectinomycin dihydrochloride;NSC 248616;856761-20-1
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CAS No:
Description
Spectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis.Target: AntibacterialSpectinomycin is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. Spectinomycin binds to the 30S subunit of the bacterial ribosome and interrupts protein synthesis. One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida [1]. It is given by injection to
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Spectinomycin hydrochloride Basic Attributes
405.27
404.111694
244-554-3
HL7KC2YV22
757319
DTXSID9045429
3004909090
Characteristics
130
-2.3
powder
1.43g/cm3
194°C
306.4ºC
1.586
H2O: 50 mg/mL, clear, faintly yellow
2-8°C
6.95None
Safety Information
2
WG7400000
P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, P501
H317
|Danger|H317 (98.21%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P285, P302+P352, P304+P341, P321, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 57 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H315 (96.08%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 54 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)
Actinospectacin
Spectinomycin hydrochloride Use and Manufacturing
Antibacterial;Ribosomal protein
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Veterinary Drug -> ANTIMICROBIAL_AGENT; -> JECFA Functional Classes
Veterinary Drug -> ANTIMICROBIAL_AGENT;
Computed Properties
Molecular Weight:368.81
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:368.1350288
Monoisotopic Mass:368.1350288
Topological Polar Surface Area:130
Heavy Atom Count:24
Complexity:478
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has moderate antibacterial effect on aerobic Gram-negative bacteria such as Escherichia coli, Klebsiella, Enterobacteriaceae, Proteus, Acinetobacter, Haemophilus influenzae, Morganella, etc., and is particularly effective against Neisseria gonorrhoeae. Among Gram-positive bacteria, it is effective against Group A Streptococcus and Staphylococcus epidermidis. Among atypical pathogens, it is sensitive to ureaplasma urealyticum. t1/2=2.5 hours. It is often used to treat uncomplicated gonorrhea such as urethritis, proctitis, acute gonorrhea, cervicitis, etc. caused by penicillin-resistant bacteria and patients with penicillin resistance. It is mainly used for urinary tract infections caused by gonococci, and is suitable for patients resistant to penicillin, tetracycline, etc.
Registered Holders
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Zhejiang Hisun Pharmaceutical Co., Ltd.
Active
China
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North China Pharmaceutical Huasheng Co., Ltd.
Active
China
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Shandong Lukang Pharmaceutical Co., Ltd.
Active
China
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