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Acrivastine

Acrivastine structure

CAS No:
87848-99-5
Formula:
C22H24N2O2
Chemical Name:
Acrivastine
Synonyms:
2-Propenoic acid,3-[6-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-2-pyridinyl]-,(2E)-;2-Propenoic acid,3-[6-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-2-pyridinyl]-,(E,E)-;2-Propenoic acid,3-[6-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-2-pyridinyl]-,(2E)-;(2E)-3-[6-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-2-pyridinyl]-2-propenoic acid;BW 825C;Acrivastine;BW A825C;BW 0270C;Semprex
Categories:
Active Pharmaceutical Ingredients > Antiallergic Drugs

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Description

Acrivastine (BW825C) is a short acting histamine 1 receptor antagonist for the treatment of allergic rhinitis.

Acrivastine Basic Attributes

Molecular Weight：

348.44

Exact Mass：

348.44

EC Number：

618-080-6

Characteristics

PSA：

53.4

XLogP3：

1.6

Appearance：

white to beige

Density：

1.2±0.1 g/cm3

Melting Point：

222 °C (decomp)

Flash Point：

289.5±30.1 °C

Refractive Index：

1.627

Water Solubility：

DMSO: >2mg/mL (warmed)

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22:Harmful if swallowed. R43:May cause sensitization by skin contact.

safety instructions：

S37/39

RTECS Number：

UD3474000

Marks：

Xn,Xi

Acrivastine Use and Manufacturing

Methods of Manufacturing

From 2, 6-dibromopyridine, 4-methylbenzonitrile, EtO2CH2P(O)(Oet)2 and (2-pyrrolidinylethyl)triphenylphosphine bromide, it is obtained through a five-step reaction.

Uses

Competitive H1 receptor antagonist. Used for allergic rhinitis, hay fever, chronic primary urticaria, skin scratches, parasympathetic urticaria, specific air-cooled urticaria, etc.

Drug Function and Efficacy

Acrivastine is a strong competitive histamine H1 receptor antagonist with no obvious anticholinergic effect. It has low penetration into the central nervous system and can relieve symptoms caused by histamine by completely or partially blocking its release.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Acrivastine Capsules
Ingredients	Acrivastine (pregnancy grade: B)
Indication	Most patients do not experience drowsiness after using Xinminli, but because each person's response to drug treatment is different, all patients who engage in high-alertness work, such as driving a car or operating machinery, should be wisely advised not to do so until they understand their reaction to the drug.
Specifications	8mg
Manufacturer	Chongqing Huapont Pharmaceutical Co., Ltd.

Acrivastine
Specifications	none
Manufacturer	Chongqing Shengkai Pharmaceutical Co., Ltd.

Acrivastine Capsules
Ingredients	Acrivastine (pregnancy grade: B)
Indication	Most patients do not experience drowsiness after using Xinminli, but because each person's response to drug treatment is different, all patients who engage in high-alertness work, such as driving a car or operating machinery, should be wisely advised not to do so until they understand their reaction to the drug.

See More Related Drugs

Registered Holders

BIOPHORE INDIA PHARMACEUTICALS PVT LTD

United States
Active
STERLING PHARMA SOLUTIONS LTD

France
Active
Chongqing Shengkai Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Acrivastine

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

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Acrivastine CAS 87848-99-5

CAS No.: 87848-99-5

Grade: Pharmaceutical Grade

Content: 99%

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