Micafungin sodium
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Micafungin sodium
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CAS No:
208538-73-2
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Formula:
C56H70N9O23S.Na
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Chemical Name:
Micafungin sodium
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Synonyms:
Micafunginsodium;1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phChemicalbookenyl]-L-threonine]pneuMocandinA0MonosodiuMSalt;Funguard;MicafunginSodiuM(FK-463,MycaMine);Mycamine;CS-705;FK463;FUNGUARD;MYCAMINE;micafunginsodiumImpurity
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CAS No:
Description
Micafungin sodium (FK 463) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.
Micafungin sodium is an organic sodium salt and an antibiotic antifungal drug.|Micafungin Sodium is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3-beta-D-glucan synthase, an enzyme essential for the synthesis of the important fungal cell wall component 1,3-beta-D-glucan. By preventing the synthesis of 1,3-beta-D-glucan, the cell wall is weakened which leads to osmotic lysis and eventually fungal cell death.|A cyclic lipo-hexapeptide echinocandin antifungal agent that is used for the treatment and prevention of CANDIDIASIS.
Safety Information
|Danger|H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P301+P312, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P314, P330, P337+P313, P391, P405, and P501|Aggregated GHS information provided by 6 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Mycamine is indicated for:Adults, adolescents ≥ 16 years of age and elderlytreatment of invasive candidiasis;treatment of oesophageal candidiasis in patients for whom intravenous therapy is appropriate;prophylaxis of Candida infection in patients undergoing allogeneic haematopoietic stem-cell transplantation or patients who are expected to have neutropenia (absolute neutrophil count < 500 cells/µl) for 10 or more days.Children (including neonates) and adolescents < 16 years of agetreatment of invasive candidiasis.prophylaxis of Candida infection in patients undergoing allogeneic haematopoietic stem-cell transplantation or patients who are expected to have neutropenia (absolute neutrophil count < 500 cells/µl) for 10 or more days.The decision to use Mycamine should take into account a potential risk for the development of liver tumours. Mycamine should therefore only be used if other antifungals are not appropriate.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)
FK 463
Micafungin sodium Use and Manufacturing
Micafungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthesis. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp.[Cayman Chemical]
Human drugs -> Mycamine -> EMA Drug Category|Antimycotics for systemic use -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:1292.3
Hydrogen Bond Donor Count:15
Hydrogen Bond Acceptor Count:24
Rotatable Bond Count:18
Exact Mass:1291.42029497
Monoisotopic Mass:1291.42029497
Topological Polar Surface Area:521
Heavy Atom Count:90
Complexity:2580
Defined Atom Stereocenter Count:15
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Competitively inhibits the synthesis of 1,3-b-D glucan, an essential component of fungal cell walls. It has broad-spectrum antifungal activity against Aspergillus and Candida, the main pathogenic fungi of deep fungal infections.
Registered Holders
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BIOCON LTD
Active
United Kingdom
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HETERO DRUGS LTD
Active
United Kingdom
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TAPI NL B.V.
Active
France
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