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2-Methylindoline

2-Methylindoline structure

CAS No:
6872-06-6
Formula:
C9H11N
Chemical Name:
2-Methylindoline
Synonyms:
1H-Indole,2,3-dihydro-2-methyl-;Indoline,2-methyl-;2,3-Dihydro-2-methyl-1H-indole;2-Methylindoline;2-Methyl-2,3-dihydroindole;2,3-Dihydro-2-methylindole;α-Methyldihydroindole;NSC 65598;2-Methyl-2,3-dihydro-1H-indole;2-Methyl-1H-indoline;(±)-2-Methylindoline;138380-84-4
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

CLEAR YELLOW TO BROWN LIQUID

2-Methylindoline is a member of indoles.

2-Methylindoline Basic Attributes

Molecular Weight：

133.19

Exact Mass：

133.19

EC Number：

229-971-0

NSC Number：

65598

HScode：

2933990090

Characteristics

PSA：

XLogP3：

2.4

Appearance：

Clear yellow to brown Liquid

Density：

1.023 g/mL at 25 °C(lit.)

Melting Point：

60.0-61.0 °C

Boiling Point：

115-117 °C

Flash Point：

200 °F

Refractive Index：

n20/D 1.569(lit.)

Water Solubility：

H2O: negligible soluble

Storage Conditions：

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-52/53-22

safety instructions：

26-36/37/39-60-57

RTECS Number：

NM1926350

Marks：

Xi,Xn

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H302 (27.59%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 74 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Methylindoline Use and Manufacturing

Methods of Manufacturing

From the hydrogenation of 2-methylindole. Heat a mixture of 130 parts of 2-methylindole, 100 parts of water and zinc amalgam (made from 196 parts of zinc) to 90°C, add 626 parts of concentrated hydrochloric acid within 30 minutes, and heat at 90-100°C for 90 minutes, Sodium hydroxide solution was added to make it alkaline, distilled, and the distillate was extracted with benzene. 2-methyl indoline was obtained.

Uses

2-Methylindoline is an intermediate in the production of various indole derivatives

Manufacturing Info：

1H-Indole, 2,3-dihydro-2-methyl-: INACTIVE

Computed Properties

Molecular Weight:133.19
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:133.089149355
Monoisotopic Mass:133.089149355
Topological Polar Surface Area:12
Heavy Atom Count:10
Complexity:122
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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