Bis(D-gluconato-κO1,κO2)copper
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Bis(D-gluconato-κO1,κO2)copper
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CAS No:
527-09-3
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Formula:
C12H22CuO14
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Chemical Name:
Bis(D-gluconato-κO1,κO2)copper
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Synonyms:
Copper,bis(D-gluconato-κO1,κO2)-;Gluconic acid,copper(2+) salt (2:1),D-;Copper,bis(D-gluconato-O1,O2)-;D-Gluconic acid,copper complex;Bis(D-gluconato-κO1,κO2)copper;Cupric gluconate;Gluconic acid,copper(2+) salt;D-Gluconic acid,copper(2+) salt;Copper(II) gluconate;Helshas Cu;Labicuper;115841-02-6;6020-31-1;79366-36-2;92266-74-5
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CAS No:
Description
Copper(II) gluconate, Cu(C6H11O7)2, is a light blue to blue-green, crystalline material that is soluble in water and slightly soluble in ethanol.
Copper gluconate is an organic molecular entity.|Copper gluconate is a copper salt of D-gluconic acid that displays a light blue to bluish-green color. It is prepared by the reaction of gluconic acid solutions with cupric oxide or basic cupric carbonate. According to the good manufacturing or feeding practice by the FDA, copper gluconate is used as a nutrient or dietary supplement and is generally recognized as safe for use at a level not exceeding 0.005 percent.|Copper Gluconate is the orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations.|Derivatives of gluconic acid (the structural formula HOCH2(CHOH)4COOH), including its salts and esters.
Bis(D-gluconato-κO1,κO2)copper Basic Attributes
453.84
453.030548
208-408-2
RV823G6G67
DTXSID4035960
C80050
Light blue crystalline powder
2918160000
Characteristics
283
155-157 °C
673.6°C at 760 mmHg
375.2ºC
16.5 ° (C=1, H2O)
H2O: slightly soluble
Combustible, fire spews spicy and irritating smoke
Specific optical rotation: +15 deg at 26 °C (concn = 1 g/100 ml water) /D-form/
Odorless
Safety Information
NONH for all modes of transport
3
24/25
LZ5058000
Warehouse low temperature, ventilated, dry
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Trace minerals added to animal feeds. These substances added to animal feeds as nutritional dietary supplements are generally recognized as safe when added are levels consistent with good feeding practice. Element: Copper; Source compound: copper gluconate. (All substances listed may be in anhydrous or hydrated form.)|Substance added directly to human food affirmed as generally recognized as safe (GRAS).|This substance is generally recognized as safe for use at a level not exceeding 0.005 percent in accordance with good manufacturing practice.
|Warning|H302 (99.5%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P314, P321, P330, P333+P313, P363, P391, and P501|Aggregated GHS information provided by 203 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1 mg/cu m. /Copper dusts and mists (as Cu)/
Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 mg/cu m. /Copper (dusts and mists)/
Bis(D-gluconato-κO1,κO2)copper Use and Manufacturing
It is derived from the reaction of gluconic acid and copper oxide, or the reaction of gluconate and copper salt and then crystallization. It can also be made by neutralizing gluconic acid with copper phosphate.
Used as food additives, pharmaceutical raw materials
Copper, bis(D-gluconato-.kappa.O1,.kappa.O2)-: ACTIVE
Cosmetics -> Skin conditioning; Skin protecting
Computed Properties
Molecular Weight:453.84
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:8
Exact Mass:453.030552
Monoisotopic Mass:453.030552
Topological Polar Surface Area:283
Heavy Atom Count:27
Complexity:165
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Copper gluconate delivers copper ions involved in collagen and elastin synthesis through lysyl oxidase activation. It contributes to skin firmness, wound repair, and antioxidant defense.
Registered Holders
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INNER MONGOLIA BAIYI Pharmaceutical Co., Ltd.
Active
China
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Jiangxi Guoyao Pharmaceutical Limited Liability Company
Inactive
China
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Hebei TIANCHENG Pharmaceutical Co., Ltd.
Inactive
China
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