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Copper(II) gluconate

Copper(II) gluconate structure

CAS No:
527-09-3
Formula:
C12H22CuO14
Chemical Name:
Copper(II) gluconate
Synonyms:
bis(d-gluconato)-coppe;D-GLUCONIC ACID, COPPER(II) SALT;COPPER(II) GLUCONATE;COPPER(II) D-GLUCONATE;CUPRIC GLUCONATE;COPPER(+2)D-GLUCONATE;COPPER GLUCONATE;GLUCONIC ACID COPPER(II) SALT
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Copper(II) gluconate, Cu(C6H11O7)2, is a light blue to blue-green, crystalline material that is soluble in water and slightly soluble in ethanol.

Copper gluconate is an organic molecular entity.|Copper gluconate is a copper salt of D-gluconic acid that displays a light blue to bluish-green color. It is prepared by the reaction of gluconic acid solutions with cupric oxide or basic cupric carbonate. According to the good manufacturing or feeding practice by the FDA, copper gluconate is used as a nutrient or dietary supplement and is generally recognized as safe for use at a level not exceeding 0.005 percent.|Copper Gluconate is the orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations.|Derivatives of gluconic acid (the structural formula HOCH2(CHOH)4COOH), including its salts and esters.

Copper(II) gluconate is the copper salt of D-gluconic acid that is an organic acid. It can be used as a buffer for encapsulating some drugs into liposomes. Copper is an essential microelement for human beings and animals; it is needed to absorb ion from and gut and can help regulate blood pressure and heart rate. It is also a key component of multiple enzymes involved in many biochemical reactions. In this sense, the D-gluconic acid copper (II) salt can be used as a copper supplement to treat the copper deficiency induced anemia and nephrosis. It is also useful in the cancer chemotherapy being capable of enhancing the efficacy of the anticancer drug, disulfiram.

ChEBI: Copper gluconate is an organic molecular entity.

When heated to decomposition it emits acrid smoke and irritating fumes.

Copper(II) gluconate Basic Attributes

Molecular Weight：

453.84

Exact Mass：

453.030548

EC Number：

208-408-2

UNII：

RV823G6G67

TSCA：

TSCA listed

DSSTox ID：

DTXSID4035960

NCI Thesaurus Code：

C80050

Color/Form：

Light Blue to Blue

HScode：

29181600

Characteristics

PSA：

283

Density：

1.777[at 20℃]

Melting Point：

155-157 °C(lit.)

Boiling Point：

673.6℃[at 101 325 Pa]

Flash Point：

375.2ºC

Refractive Index：

16.5 ° (C=1, H2O)

Water Solubility：

slightly soluble

Vapor Pressure：

13.3Pa at 20℃

Flammability characteristics：

Not classified

Specific rotation：

Specific optical rotation: +15 deg at 26 °C (concn = 1 g/100 ml water) /D-form/

Odor：

Odorless

Critical Temperature & Pressure：

Inert atmosphere,Room Temperature

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

LZ5058000

Storage features：

Warehouse low temperature, ventilated, dry

Disposal Methods：

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

FDA Requirements：

Trace minerals added to animal feeds. These substances added to animal feeds as nutritional dietary supplements are generally recognized as safe when added are levels consistent with good feeding practice. Element: Copper; Source compound: copper gluconate. (All substances listed may be in anhydrous or hydrated form.)|Substance added directly to human food affirmed as generally recognized as safe (GRAS).|This substance is generally recognized as safe for use at a level not exceeding 0.005 percent in accordance with good manufacturing practice.

GHS Classification：

|Warning|H302 (99.5%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P272, P273, P280, P301+P312, P302+P352, P314, P321, P330, P333+P313, P363, P391, and P501|Aggregated GHS information provided by 203 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

OSHA Standards：

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1 mg/cu m. /Copper dusts and mists (as Cu)/

NIOSH Recommendations：

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 mg/cu m. /Copper (dusts and mists)/

Toxicity

Human Exposure：

ACGIH: TWA 1 mg/m3NIOSH: IDLH 100 mg/m3; TWA 1 mg/m3

Drug Information

MeSH Entry Terms：

Copper Gluconate

Copper(II) gluconate Use and Manufacturing

Methods of Manufacturing

It is derived from the reaction of gluconic acid and copper oxide, or the reaction of gluconate and copper salt and then crystallization. It can also be made by neutralizing gluconic acid with copper phosphate.

Uses

Used as food additives, pharmaceutical raw materials

Supplement (trace mineral).

copper gluconate is cited as having skin-conditioning and skinprotecting functions.

Copper(II) gluconate is used in dietary supplement. It is also used to treat acne vulgaris, common cold, hypertension, premature labor, leishmaniasis and visceral postoperative complications. Further, it is used in oral deodorants and feed additives. In addition to this, it is used as a synergist and nutritional supplement for foods. It is the active component in retsyn used in mints and certs.

Manufacturing Info：

Copper, bis(D-gluconato-.kappa.O1,.kappa.O2)-: ACTIVE

Use Classification：

Cosmetics -> Skin conditioning; Skin protecting

Computed Properties

Molecular Weight:453.84
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:8
Exact Mass:453.030552
Monoisotopic Mass:453.030552
Topological Polar Surface Area:283
Heavy Atom Count:27
Complexity:165
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Material

Sorbitol

Sodium gluconate

Copper sulfate

Drug Function and Efficacy

Copper gluconate delivers copper ions involved in collagen and elastin synthesis through lysyl oxidase activation. It contributes to skin firmness, wound repair, and antioxidant defense.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

LA ROCHE POSAY LABORATOIRE DERMATOLOGIQUE CICAPLAST BALM B5 SOOTHING THERAPEUTIC MULTIPURPOSE- dimethicone_cream
Manufacturer	L'Oreal USA Products Inc

Registered Holders

INNER MONGOLIA BAIYI Pharmaceutical Co., Ltd.

China
Active
Jiangxi Guoyao Pharmaceutical Limited Liability Company

China
Inactive
Hebei TIANCHENG Pharmaceutical Co., Ltd.

China
Inactive

Recommended Suppliers of Copper(II) gluconate

Tianjin Luis Biotechnology Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Food Additives

Wholesale Price High Quality Food Grade Raw Material CAS 527-09-3 Copper Gluconate/Copper (II) Gluconate Powder

Unit Price: $6.9 /KG FOB

CAS No.: 527-09-3

Grade: Food Grade

Content: 99%

Inquiry
Hangzhou Hyper Chemicals Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

API Wedelolactone

CAS No.: 527-09-3

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Honour Enterprise Company Limited Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of Semaglutide,Tirzepatide,API,Enzyme

More than 15 years GMP Factory Suppy 99.5% Copper gluconate Medical Grade CAS527-09-3

CAS No.: 527-09-3

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry
LIAOYANGTENGYUAN FOOD ADDITIVE FACTORY Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Zinc gluconate,Ferrous gluconate,Copper gluconate,Magnsium gluconate,Manganese gluconate,Potassium gluconate,Cobalt gluconate,Nickel gluconate,Lithium gluconate

Copper Gluconate USP/FCC

CAS No.: 527-09-3

Grade: Food Grade

Content: 98.0%

Inquiry
Shandong Ailike New Material Technology Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of API,Antibiotics,Anti cancer category

Copper gluconate

CAS No.: 527-09-3

Grade: pharmaceutical grade

Content: 99%

Inquiry

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