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2,5-Dichloropyridine

2,5-Dichloropyridine structure

CAS No:
16110-09-1
Formula:
C5H3Cl2N
Chemical Name:
2,5-Dichloropyridine
Synonyms:
Pyridine,2,5-dichloro-;2,5-Dichloropyridine;NSC 528661;5-Chloro-2-chloropyridine
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

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Description

white to slightly yellow crystalline solid

2,5-Dichloropyridine Basic Attributes

Molecular Weight：

147.986

Exact Mass：

147.99

EC Number：

240-278-2

UNII：

FZ623S5E22

NSC Number：

528661

DSSTox ID：

DTXSID7051765

HScode：

29333990

Characteristics

PSA：

12.9

XLogP3：

2.4

Appearance：

White to light yellow

Density：

1.5159 (rough estimate)

Melting Point：

59-62 °C

Boiling Point：

190-191 °C

Flash Point：

112 °C

Refractive Index：

1.5500 (estimate)

Water Solubility：

insoluble

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Vapor Pressure：

0.904mmHg at 25°C

Safety Information

Hazard category：

IRRITANT 6.1

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22;R36/37/38

safety instructions：

26-37/39-36

RTECS Number：

US8225000

Marks：

Xi,Xn

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H302 (13.04%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2,5-Dichloropyridine Use and Manufacturing

General procedure: A Schlenk tube was charged with catalyst 1 (10 mol percent), aryl (or heteroaryl) bromide (1.0 mmol), tetramethylammonium chloride (Me(1) 53.3 g of 3, 4, 5, 6-tetrachloropicolinic acid, 500 ml of water and 88.0 g of 30percent sodium hydroxide were mixed together, 1000ml high pressure reactor;(2) Add 2 g of 5percent Pt / C to the reaction kettle, tightly seal the reaction kettle, replace with nitrogen 3 times, and let the pressure reach 0.4Mpa, then heat to 50 while stirring, So that the reactor pressure to 0.5Mpa after reaction, HPLC detection reaction completely, cooling to room temperature, the reaction solution;(3) The reaction liquid of step (2) is poured out, and the catalyst is recovered by filtration. The filtrate is acidified to pH 1-2 with 30percent hydrochloric acid, then cooled and crystallized, centrifuged, precipitated and washed with water to obtain 3, 6-dichloropyridine acid 26.5 g, content 97.9percent, yield 82.3percent.

Computed Properties

Molecular Weight:147.99
XLogP3:2.4
Hydrogen Bond Acceptor Count:1
Exact Mass:146.9642545
Monoisotopic Mass:146.9642545
Topological Polar Surface Area:12.9
Heavy Atom Count:8
Complexity:76.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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