Ornithine aspartate
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Ornithine aspartate
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CAS No:
3230-94-2
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Formula:
C5H12N2O2.C4H7NO4
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Chemical Name:
Ornithine aspartate
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Synonyms:
L-Aspartic acid,compd. with L-ornithine (1:1);Aspartic acid,L-,compd. with L-ornithine (1:1);Ornithine,L-,L-aspartate (1:1);L-Ornithine,L-aspartate (1:1);Ornithine aspartate;Hepamerz;L-Ornithine L-aspartate;Ormeta;Orparan;Aspartic acid compd. with ornithine;Ruigan;3054-39-5;91055-05-9;886996-48-1
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CAS No:
Description
L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis[1].
Ornithine aspartate Use and Manufacturing
22.5 g of L-ornithine acetate (monohydrate), 13.3 g of L-aspartic acid, Add 20mL of purified water, Stir.A solution of ammonium carbonate (9.9 g of ammonium carbonate dissolved in 40 mL of purified water) was added dropwise to the above suspension and CO2 gas evolution accompanied by a slight exotherm (control of dropping rate).The suspension becomes clear.Plus, Continue stirring for 10 minutes, The pH of the reaction solution is about 7.0-8.0.Heated to 70-80 , Slowly add methanol 150mL, A solid precipitation.Insulation crystallization 2h, Slowly down to room temperature, Continue stirring 2h.filter, Solid first with methanol: water = 4: 1 mixture of about 50mL rinse once, Then rinsed with methanol (50 mL x 2).Drained, had wet solid 21.7g. No drying, directly for refining.Aspartic acid ornithine wet crude 21.7g, Add purified water 42mL, Stir to dissolve.Warmed to 60-70 ° C, Add about 0.6g activated carbon, Thermal decolorization 30 minutes.filter, The filtrate was warmed to 70-80 ° C, Slowly add methanol dropwise about 84mL.A solid precipitation.After all drops, Continue stirring 2h.Slowly down to room temperature, Continue stirring 2h.filter.Methanol: water = 4: 1 mixture (50 ml × 2), Methanol wash (50 mL × 2).Drained and dried under reduced pressure to give 18.3 g.Specific rotation + 28.1 °, content of 99.56percent.
Drug Function and Efficacy
It can provide substrates for the synthesis of urea and glutamine. Under physiological and pathological conditions, the synthesis of urea and glutamine will be affected by ornithine, aspartic acid and other dicarboxyl compounds. Ornithine is involved in almost the entire process of urea cycle activation and ammonia detoxification. In this process, arginine is formed, and then urea is split to form ornithine. Aspartic acid participates in the synthesis of nucleic acids in liver cells to help repair damaged liver cells. In addition, due to the indirect promotion of aspartic acid on the tricarboxylic acid cycle metabolic process in liver cells, it promotes energy generation in liver cells, allowing the various functions of damaged liver cells to be restored.
Registered Holders
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Beijing Yimingyuan Pharmaceutical Technology Co., Ltd.
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China
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Zhejiang Cheng Yi Pharmaceutical Co., Ltd.
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China
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Evonik Specialty Chemicals(Shanghai) Co., Ltd.
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China
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